01 Research Summary
A brain is the device that processes huge amount of information via nerve cells called neurons. Various bioactive substances intervene in the exchange of information between neurons. There are two ways for the transmission, via or without synapses, and neurotransmitters play important roles in both processes. Among various kinds of neurotransmitter, our lab is interested in neuropeptides in our brains. We aim to discover and elucidate the function and operation mechanisms of unknown neuropeptides. Neuropeptide is evolutionarily ancient system and deeply related to eating behavior, sleep, emotion, and so on. Along with its academic values, the elucidation of functions of neuropeptides may lead to treatments of various diseases.
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02 Major achievement
Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai. Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science. 2022 Mar 4;375(6584):994-1000, 2022
Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T. A discrete neuronal circuit induces a hibernation-like state in rodents. Nature. 2020 Jul;583(7814):109-114, 2020
Sakurai T, et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585, 1998
Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopetide-selective subtype of the endothelin receptor. Nature 48:732-735, 1990
03 Education/Academic background and major awards
Education/Academic background
1964 | Born in Tokyo |
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1993 | Ph.D. Faculty of Medicine, University of Tsukuba |
1993 - 1993 | Postdoctoral Fellow, Research Fellowship for Young Scientist(JSPS) |
1993 - 1999 | Lecturer, Faulty of Medicine, University of Tsukuba |
1999 - 2004 | Associate Professor, Faulty of Medicine, University of Tsukuba |
2004 - 2008 | Associate Professor, Graduate School of Comprehensive Human Sciences, University of Tsukuba |
2008 - 2016 | Professor, Graduate School of Medical Sciences, Kanazawa University |
2016 | Present Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba |
awards
The 11th Tsukuba Encouragement Prize/ The 14th Ando Momokufu Award/ The 65th Chunichi Cultural Award/ Prizes for Science and Technology, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (MEXT)/The 2nd Shiono Award/ The 32th Tsukuba Prize
Why did you become a scientist?
I somehow started researching and somehow ended up here.
During my fifth year of Medicine in University of Tsukuba, Dr. Yanagisawa, who just discovered endothelin, asked me to join his research, saying that “the interesting part of endothelin research was about to begin.” I wanted to become a doctor at the time, but the research sounded interesting and I decided to try it out for a while; I always thought that I could always go back to my path to be a medical doctor if the research did not go well. I also thought that, since I decided to work on this research project, I wanted to at least achieve something interesting in this field. I had too many sleepless nights, but it paid off in the end when we discovered the molecule structure of endothelin receptor. I got a position of lecturer after I completed my Master’s Degree. I sort of continued from there and ended up where I am now. I somehow forgot about the wish to become a doctor.
What are the characteristics of your lab?
Freedom.
Try not to set too many restrictions on what they wish to do. They are exceptionally talented and I believe that their self-reliance could provide a better output in their research than having myself interfering every step of the way. I set up the goal, but allow them to select any routes he/she likes to reach it. I would, of course, not leave them unsupervised and provide supports and make corrections when necessary; however, I will not do anything that could jeopardize their self-reliance. I try not to make any borders between researchers and students or treat them unequally, and provide a talkative environment.
What are you most interested in lately
Motor sports, photography, and Audio.
Since I was a university student, I went to circuits to drive racing karts and formula cars. I used to participate in gymkhana or other types of auto racing. When my lab was moved to Kanazawa University, there was not much time and no circuits nearby were available, so I started my new hobby, taking photos with cameras. I love playing around with machines so I guess that is why I like cameras as well as cars. I also like music, and it most likely something to do with audio devices.
Core Group
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Neuroscience
Masashi Yanagisawa
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Neuroscience
Takeshi Sakurai
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Neuroscience
Hiromasa Funato
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Neuroscience
Yu Hayashi
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Neuroscience
Michael Lazarus
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Neuroscience
Yo Oishi
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Neuroscience
Masanori Sakaguchi
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Neuroscience
Kaspar Vogt
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Neuroscience
Katsuyasu Sakurai
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Neuroscience
Sakiko Honjoh
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Neuroscience
Hirofumi Toda
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Neuroscience
Arisa Hirano
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Neuroscience
Robert Greene
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Neuroscience
Qinghua Liu
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Drug discovery
Noriki Kutsumura
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Drug discovery
Tsuyoshi Saitoh
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Human sleep
Tomohiro Okura
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Human sleep
Takashi Kanbayashi
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Human sleep
Takashi Abe
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behavioral science
Shun Nakajima
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Data Science
Hiroyuki Kitagawa
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Data Science
Shoi Shi
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Data Science
Masao Iwagami