Satoru Takahashi

Affiliation：Faculty of Medicine, University of Tsukuba

Research Title

Neuroscience

Functional analysis of Large Maf transcription factors and glycosyltransfeases in vivo./Generation of genetically modified mice by genome editing.

01 Research Summary

1. Functional analysis of Large Maf transcription factors in vivo.

Large Maf transcription factors are expressed in pancreatic endocrine cells, macrophage lineage in hematopoietic system and podocyte in the kidney and also related to some human diseases. We are trying to elucidate functions of Large Maf transcription factors in the body by using genetically modified mice.

2. Analysis about in vivo functions of sugar chains on biological macromolecules.

Biological macromolecules in the body are modified by various kinds of sugar chains, but functions of these sugar chains are not fully understood. We are analyzing functions of sugar chains on biological macromolecules in vivo by using glycosiltransferase deficient mice.

3. Generation of genetically modified mice by genome editing.

Generation of genetically modified mouse related to sleep research by genome editing.

Link	Takahashi Lab

Takahashi Lab

02 Major achievements

Fujino M, Morito N, Hayashi T, Ojima M, Ishibashi S, Kuno A, Koshiba S, Yamagata K, Takahashi S(2023) Transcription factor c-maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.JCI Insight. 8(6):e163306. doi:10.1172/jci.insight.163306

Staci J Kim, Noriko Hotta-Hirashima, Fuyuki Asano, Tomoyuki Kitazono, Kanako Iwasaki, Shinya Nakata, Haruna Komiya, Nodoka Asama, Taeko Matsuoka, Tomoyuki Fujiyama, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Jinhwan Choi, Deependra Kumar, Takumi Tsukamoto, Asmaa Elhosainy, Seiya Mizuno, Shinichi Miyazaki, Yousuke Tsuneoka, Fumihiro Sugiyama, Satoru Takahashi, Yu Hayashi, Masafumi Muratani, Qinghua Liu, Chika Miyoshi, Masashi Yanagisawa, Hiromasa Funato. Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature, 612, 512-518, 2022

Marta Larrayoz, Maria J. Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Cristina Perez, Raquel Ordoñez, Cesar Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, Maria J. Larrayoz, Maria J. Calasanz, Elena Campos-Sanchez, Jorge Martinez-Cano, Carlos Panizo, Paula Rodriguez-Otero, Silvestre Vicent, Giovanna Roncador, Patricia Gonzalez, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llopiz, Pablo Sarobe, Juan J. Lasarte, Nuria Planell, David Gomez-Cabrero, Olga Kudryashova, Anna Kurilovich, Maria V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesus San Miguel, Bruno Paiva, Felipe Prosper, Jose A. Martinez-Climent. Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma. Nature Medicine, 29, 632–645, 2023

Manami Katoh, Seitaro Nomura, Shintaro Yamada, Masamichi Ito, Hiroki Hayashi, Mikako Katagiri, Tuolisi Heryed, Takayuki Fujiwara, Norifumi Takeda, Miyuki Nishida, Maki Sugaya, Miki Kato, Tsuyoshi Osawa, Hiroyuki Abe, Yoshitaka Sakurai, Toshiyuki Ko, Kanna Fujita, Bo Zhang, Satoshi Hatsuse, Takanobu Yamada, Shunsuke Inoue, Zhehao Dai, Masayuki Kubota, Kousuke Sawami, Minoru Ono, Hiroyuki Morita, Yoshiaki Kubota, Seiya Mizuno, Satoru Takahashi, Makoto Nakanishi, Tetsuo Ushiku, Hironori Nakagami, Hiroyuki Aburatani, Issei Komuro. Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7. CIRCULATION. 150, 374-389, 2024.

03 Education/Academic background and major awards

Education/Academic background

1987	Graduated from School of Medicine, Tohoku University
1991	Graduated from Doctoral Program in Medical Sciences, Tohoku University
1991 - 1994	Post-doctoral fellow, CMU University of Geneva, Switzerland
1994 - 1995	Medical Staff, Department of Pathology, Tohoku University Hospital
1995 - 1996	Assistant Professor, Institute of Medicine, Tohoku University
1996 - 1998	Assistant Professor, Institute of Basic Medical Sciences (now Faculty of Medicine), University of Tsukuba (Molecular Developmental Biology)
1998 - 2000	: Assistant Professor, Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
2000 - 2004	Professor, Institute of Basic Medical Sciences(now Faculty of Medicine), University of Tsukuba
2001 - Present	Professor, Laboratory Animal Resource Center, University of Tsukuba
2004 - 2011	Professor, Graduate School of Comprehensive Human Sciences, University of Tsukuba
2009 - 2015	Director, Laboratory Animal Resource Center, University of Tsukuba
2011 - Present	Professor, Faculty of Medicine, University of Tsukuba
2017 - 2023	Director, Transborder Medical Research Center, University of Tsukuba
2024 - Present	Chairperson, Faculty of Medicine, University of Tsukuba

Awards

1992	Silver Prise, Gonryo Medical Foundation, Tohoku University
2018年	2018 ISS Award for Compelling Results
2020年	The Ando-Tajima Award, Japanese Association for Laboratory Animal Science
2020年	Award for Science and Technology, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

Core Group

University of Tsukuba Collaborative Research Group

Administrative Department