Katsuyasu Sakurai

Affiliation:International Institute for Integrative Sleep Medicine, University of Tsukuba

Research Title

Neuroscience

Neural mechanisms underlying desires for sex and sleep

01 Research Summary

What is the purpose for all living things? If think thoroughly, all behaviors of human and other organisms aim to fulfill their desires to live. The ultimate goal of my research is to understand the neural mechanisms underlying the desires to live.

I focus on the two fundamental desires which are evolutionarily conserved in all organisms; desire for sex, and desire for sleep.

The biological purpose of sex is to transfer the genes to the next generation. In other words, the desire of sex is the desire for future life. In my view, the desire for sex may be fulfilled by achieving the “orgasm”, hence, the central question is: what is the neural representation of orgasm in the brain. In case of the male mouse, sex consists of a series of sequential behaviors: female recognition, chasing, mounting, intromission and ejaculation as the climax. It is often thought that ejaculation triggers orgasm or vice versa. Thus, we are in the process of identifying the neural ensemble that encodes orgasm using histological and imaging techniques. Afterwards, we will investigate the causality between the neural activity of the specific neural population and ejaculation/orgasm.

Furthermore, sexual activities increase sleep need. Thus, I’m interested in studying how sexual behaviors regulate sleep need. To address this question, I will focus on sexual satiety. It is known that several times of ejaculation induces post ejaculation refractory period and this condition would be the representation of sexual satiety. I speculate that sexual satiety would be the key phenomena for studying how sexual behaviors affect sleep need. I will attempt to reveal the neural basis of sexual satiety induced sleep changes.

Link

02 Major achievements

Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, Han BX, Ryu D, Yin H, Liedtke W, Wang F. “A craniofacial-specific monosynaptic circuit enables heightened affective pain” Nature Neuroscience. 2017, 20(12), 1734-1743.

Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt A, Fu M, Han BX, Wang F. “Capturing and manipulating activated neuronal ensembles with CANE delineates a hypothalamic social-fear circuit” Neuron. 2016, 92(4), 739-753.

Sakurai K, Akiyama M, Cai B, Scott A, Han BX, Takatoh J, Sigrist M, Arber S, Wang F. “The organization of submodality-specific touch afferent inputs in the vibrissa column” Cell Reports. 2013, 5(1), 87-98.

03 Education/Academic background and major awards

Education/Academic background

2008Mar Tohoku University, Sendai, Miyagi, Japan Ph.D. in Medical Science
2008Apr-2008Oct Postdoctoral Fellow at Tohoku University, Sendai, Miyagi, Japan
2008Nov-2013Oct Postdoctoral Fellow at Duke University, Durham, NC, USA
2013Nov-2017Jun Research Associate Senior at Duke University, Durham, NC, USA
2017Jul-Present Assistant Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Awards

2008 Tohoku University, Graduate School of Medicine, Scholarship award
2013 Duke University, Department of Neurobiology, Graduate Program Retreat, Best poster presentation award

Q&A Q&A

Why did you become a scientist?

I just wanted to live abroad. The scientist seems cool. (Now, I don’t think so)

What do you care about at work?

I just want to do something interesting.

What are you most interested in lately?

Nothing.