Takashi KanbayashiTakashi Kanbayashi

Affiliation:International Institute for Integrative Sleep Medicine, University of Tsukuba

Research Title

Human sleep

Elucidating the pathogenesis of central hypersomnia and schizophrenia through research on neural autoantibodies

01 研究概要

It has already been 20 years since orexin was discovered, but it is still the only biochemical marker for diagnosis of sleep wake disorders. Other than orexin, diagnosis is made only by sleep polygraph examinations and clinical symptoms. Since orexin is decreased in narcolepsy, it has been measured from 2000 for a definitive diagnosis for narcolepsy and about 3000 samples have been measured. Orexin is also an important biomarker of symptomatic hypersomnia due to hypothalamic lesions. We have reported symptomatic narcolepsy due to AQP4 antibody as the first sleep wake disorder involving an autoimmune mechanism. In addition to cases with hypothalamic lesion, it has been reported that orexin decreases and symptomatic narcolepsy occurs in hereditary diseases and neurodegenerative diseases. One of the goals of our group is to clarify the pathophysiology of hypersomnia through the study of symptomatic narcolepsy. Similar to AQP4 antibody, NMDA receptor antibody that acts on the surface of cell membranes causes NMDA receptor encephalitis with psychosis. Schizophrenia is a disease of unknown cause, but we believe that it may also develop due to an autoimmune mechanism, such as NMDA receptor antibody. We are continuing to consider this direction of research.