ResearchResearch Articles

Nakamura Y, Matsuzaka, T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A (2018) Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation. Cell Death & Disease 9:1181. doi:10.1038/s41419-018-1226-1

Bjorness TE, Greene RW (2018) Sleep deprivation alters the time course but not magnitude of locomotor sensitization to cocaine. Sci Rep. 8:17672. doi:10.1038/s41598-018-36002-1

Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Mishima K, Honda M, Tokunaga K et al. (2018) A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia. J. Hum. Genet. 63(12):1259-1267 doi:10.1038/s10038-018-0518-8

Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, Sakurai T (2018) Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture. Front Neurosci. 12:892 doi:10.3389/fnins.2018.00892

Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M (2018) Sleep and Wakefulness Are Controlled by Ventral Medial Midbrain/Pons GABAergic Neurons in Mice. J Neurosci. 38(47):10080-10092. doi:10.1523/JNEUROSCI.0598-18.2018

Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa H, Takahashi S, Ema M (2018) Klf5 suppresses ERK signaling in mouse pluripotent stem cells. PLoS One 13(11):e0207321 doi:10.1371/journal.pone.0207321

Saitoh A, Soda A, Kayashima S, Yoshizawa K, Oka JI, Nagase H, Yamada M (2018) A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice. J Pharmacol Sci. 138(3):176-183. doi:10.1016/j.jphs.2018.09.009

Kaushik MK, AritakeK, Cherasse Y, Sharma R, Urade Y (2018) A gain-of-function study of amelioration of pentylenetetrazole-induced seizures by endogenous prostaglandin D-2 Neurosci Lett. 686:140-144. doi:10.1016/j.neulet.2018.09.011

Kutsumura N, Nagase H (2018) Unique Reactions of Morphinan Skeletons and Conversions of the Skeletons to Active Alkaloids. J Syn Org Chem Jpn. [Japanese: 有機合成化学協会誌] 76(9):914-921. doi:10.5059/yukigoseikyokaishi.76.914

Kutsumura N, Okada T, Imaide S, Fujii H, Nagase H (2018) Acetic Anhydride Mediated Retro-Ene Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage. Synthesis-Stuttgart 50(21):4263-4269. 10.1055/s-0036-1589138

Zhang Y, Sugai T, Yamamoto T, Yamamoto, N, Kutsumura N, Nishiyama S, Einaga Y, Saitoh, T, Nagase H (2018) Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions. ChemElectroChem. 5. 10.1002/celc.201801308.

Kuwano N, Kato, TA, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S (2018) Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study. J Affect Disorders. 240:88-98. doi:10.1016/j.jad.2018.07.040

Murata K, Lu WZ, Hashimoto M, Ono N, Muratani M, Nishikata K, Kim JD, Ebihara S, Ishida J, Fukamizu A (2018) PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products. iScience. 8:200-+. doi:10.1016/j.isci.2018.09.023

Sakikubo M, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, Goto T, Hirata K, Masui T, Dor Y, Fujiyama T, Hoshino M, Uemoto S, Kawaguchi Y (2018) Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway. Sci Rep. 8:15812. doi:10.1038/s41598-018-34093-4

Cherasse Y, Aritake K, Oishi Y, Kaushik MK, Korkutata M, Urade Y (2018) The Leptomeninges Produce Prostaglandin D-2 Involved in Sleep Regulation in Mice. Front Cell Neurosci. 12:357. doi:10.3389/fncel.2018.00357

Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M (2018) A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice Proc Natl Acad Sci USA. 115(41):10458-10463. doi:10.1073/pnas.1810823115

Sugiyama A, Yamada M, Saitoh A, Nagase H, Oka JI, Yamada M (2018) Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats. Psychopharmacology. 235(10):2947-2955. doi:10.1007/s00213-018-4984-7

Kulathunga K, Hamada M, Hiraishi Y, Otake M, Tran MTN, Cheng O, Tanaka J, Sakasai T, Sakaguchi S, Sugiyama Y, Fleischmann BK, Takahashi S, Miwa Y (2018) A Novel iRFP-Incorporated in vivo Murine Atherosclerosis Imaging System. Sci Rep. 8:14515. doi: 10.1038/s41598-018-32456-5

Kutsumura N, Kiriseko A, Niwa K, Saito T (2018) Total Syntheses of 3-epi-Litsenolide D-2 and Lincomolide A. J Org Chem. 83(18):11450-11457. doi:10.1021/acs.joc.8b01825

Mochizuki A, Nakayama K, Nakamura S, Dantsuji M, Kamijo R, Shioda S, Sakurai T, Ozeki M, Inoue T (2018) Involvement of orexin in lipid accumulation in the liver. J Oral Sci. 60(3):76-82. doi:10.1016/j.job.2018.07.001

Takaya D, Inaka K, Omura, A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A (2018) Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies. Bioorgan Med Chem. 26(16):4726-4734. doi:10.1016/j.bmc.2018.08.014

Niwa Y, Kanda GN, Yamada RG, Shi S, Sunagawa GA, Ukai-Tadenuma M, Fujishima H, Matsumoto N, Masumoto K, Nagano M, Kasukawa T, Galloway J, Perrin D, Shigeyoshi Y, Ukai H, Kiyonari H, Sumiyama K, Ueda HR (2018) Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep. Cell Reports. 24(9):2231. doi:10.1016/j.celrep.2018.07.082

Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M (2018) Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response. Front Neurosci. 12:535. doi:10.3389/fnins.2018.00535

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawas A, Narumiya S, Furuyashiki T (2018) Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. 23(8):1717-1730. doi:10.1038/mp.2017.177

Sato Y, Tsukaguchi H, Takahashi S, Yoshimura A et al. (2018) A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. Kidney Int. 94(2):396-407. doi:10.1016/j.kint.2018.02.025

Yoshida S, Ohnishi R, Tsuneoka Y, Yamamoto-Mimura Y, Muramatsu R, Kato T, Funato H, Kuroda KO (2018) Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups. Front Cell Neurosci. 12:204. doi:10.3389/fncel.2018.00204

Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T (2018) Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons. J Neurosci. 38(28):6366-6378. doi:10.1523/JNEUROSCI.2835-17.2018

Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima Y, Yanagisawa M, Funato H, Hoshino M (2018) Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain. Cell Reports 24(1):79-94. doi:10.1016/j.celrep.2018.06.010

Araki M, Nakagawa Y, Oishi A, Han S, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H (2018) The Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha)Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 19(7):2148. doi:10.3390/ijms19072148

Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N, Shimano H (2018) Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes. Diabetes Res Clin Pract. 141:237-243. doi:10.1016/j.diabres.2018.05.019

Wang ZQ, Ma J, Miyoshi C, Lie YX, Sato M, Ogawa Y, Lou TT, Ma CY, Gao X, Lee C, Fujiyama T, Yang XJ, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao LQ, Takahashi S, Peng JM, Yu YH, Funato H, Yanagisawa M, Liu QH (2018) Quantitative phosphoproteomic analysis of the molecular substrates of sleep need. Nature. 558(7710):435-439. doi:10.1038/s41586-018-0218-8

Yajima K, Iwayama K, Ogata H, Park I, Tokuyama K (2018) Meal rich in rapeseed oil increases 24-h fat oxidation more than meal rich in palm oil. PLoS One. 13(6):e0198858. doi:10.1371/journal.pone.0198858

Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M (2018) Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy. Proc Natl Acad Sci USA. 23:6046-6051. doi:10.1073/pnas.1722686115

Schoonakker M, Meijer JH, Deboer T, Fifel K (2018) Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus. Sleep. 41(6): zsy051. doi:10.1093/sleep/zsy051

Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han S, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H (2018) Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Endocrinology. 159(6):2308-2323. doi:10.1210/en.2017-03179

Oda S, Tsuneoka Y, Yoshida S, Adachi-Akahane S, Ito M, Kuroda M, Funato H (2018) Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex. J Comp Neurol. 526(8):1329-1350. doi:10.1002/cne.24409

Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM (2018) Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control. J Neurosci. 38(22):5168-5181. doi:10.1523/JNEUROSCI.2955-17.2018

Honjoh S, Sasai S, Schiereck SS, Nagai H, Tononi G, Cirelli C (2018) Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus. Nat Commun. 9:2100. doi:10.1038/s41467-018-04497-x

Bjorness TE, Greene RW (2018) Dose response of acute cocaine on sleep/waking behavior in mice. Neurobiol Sleep Circadian Rhythms. 5:84-93. doi:10.1016/j.nbscr.2018.02.001

Wang YB, Cao LQ, Lee CY, Matsuo T, Wu KJ, Asher G, Tang LJ, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Cherasse Y, Zhou JM, Li YWB, Wang T, Zhan XW, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang ZQ, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu QH (2018) Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun. 9:2041. doi:10.1038/s41467-018-04324-3

Fifel K, Meijer JH, Deboer T (2018) Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures. Sci Rep. 8:7765. doi:10.1038/s41598-018-25770-5

Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T, Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H (2018) Molecular association model of PPAR alpha and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARM alpha. Biochem Biophys Res Commun. 499(2):239-245. doi:10.1016/j.bbrc.2018.03.135

Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, Kokubo T, Kurokawa T (2018) Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS One. 13(5):e0196422. doi:10.1371/journal.pone.0196422

Toyama S, Shimoyama N, Tagaito Y, Nagase H, Saitoh T, Yanagisawa M, Shimoyama M (2018) Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats. Anesthesiology. 128(5):992-1003. doi:10.1097/ALN0000000000002161

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B (2018) Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology. 133:395-403. doi:10.1016/j.neuropharm.2018.02.010

Luo YJ, Li YD, Wang L, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, Huang ZL (2018) Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D-1 receptors. Nat Commun. 9:1576. doi:10.1038/s41467-018-03889-3

Yang SR, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DR, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL (2018) The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLOS Biol. 16(4): e2002909. doi:10.1371/journal.pbio.2002909

Katoh MC, Jung YS, Ugboma CM, Shimbo M, Kuno A, Basha WA, Kudo T, Oishi H, Takahashi S (2018) MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic alpha Cells In Vivo. Mol Cell Biol. 38(8): e00504-17. doi:10.1128/MCB.00504-17

Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H (2018) Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. Pharmacol Rep. 70(2):350-354. doi:10.1016/j.pharep.2017.08.018

Monma T, Ando A, Asanuma T, Yoshitake Y, Yoshida G, Miyazawa T, Ebine N, Takeda S, Omi N, Satoh M, Tokuyama K, Takeda F (2018) Sleep disorder risk factors among student athletes. Sleep Med. 44(76):76-81. doi:10.1016/j.sleep.2017.11.1130

Yamamoto T, Akahori M, Natsui K, Saitoh T, Einaga Y (2018) Controlled decoration of boron-doped diamond electrodes by electrochemical click reaction (e-CLICK). Carbon. 130:350-354. doi:10.1016/j.carbon.2017.12.098

Kitada N, Saitoh T, Ikeda Y, Iwano S, Obata R, Niwa H, Hirano T, Miyawaki A, Suzuki K, Nishiyama S, Maki SA (2018) Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution. Tetrahedron Lett. 59(12)1087-1090. doi:10.1016/j.tetlet.2018.01.078

Yamamoto T, Riehl B, Naba, K, Nakahara K, Wiebe A, Saitoh T, Waldvogel SR, Einaga Y (2018) A solvent-directed stereoselective and electrocatalytic synthesis of diisoeugenol. Chem Commun 54(22):2771-2773. doi:10.1039/c8cc00794b

Kutsumura N, Koyama Y, Suzuki Y, Tominaga K, Yarnarnoto N, Saitoh T, Nagumo Y, Nagase H (2018) Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton. Org Lett. 20(6):1559-1562. doi:10.1021/acs.orglett.8b00288

Kaida K, Abe T (2018) Attentional lapses are reduced by repeated stimuli having own-name during a monotonous task. PLoS One. 13(3): e0194065. doi:10.1371/journal.pone.0194065

Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H, Yanagisawa M (2018) Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice. Sleep. 41(3): zsx209. doi:10.1093/sleep/zsx209

Fox BM, Becker BK, Loria AS, Hyndman KA, Jin CH, Clark H, Johns R, Yanagisawa M, Pollock DM, Pollock JS (2018) Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1. J Am Heart Assoc. 7(4): e007863. doi:10.1161/JAHA.117.007863

Ikeda Y, Saitoh T, Niwa K, Nakajima T, Kitada N, Maki SA, Sato M, Citterio D, Nishiyama S, Suzuki K (2018) An allylated firefly luciferin analogue with luciferase specific response in living cells. Chem Commun. 54(14):1774-1777. doi:10.1039/c7cc09720d

Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2018) Essential structure of orexin 1 receptor antagonist YNT-707, Part II:Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity. Bioorg Med Chem Lett. 28(4):774-777. doi:10.1016/j.bmcl.2017.12.069

Yuan XM, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y (2018) Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Nat Commun. 9:636. doi:10.1038/s41467-018-03038-w

Garcia SV, Brischoux F, Clement O, Libourel PA, Arthaud S, Lazarus M, Luppi PH, Fort P (2018) Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. Nat Commun. 9:504. doi:10.1038/s41467-017-02761-0

Jung YS, Zhou, RY, Kato T, Usui, JK, Muratani, M, Oishi H, Heck MMS, Takahashi S (2018) Isl1 beta Overexpression With Key beta Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion. Endocrinology. 159(2):869-882. doi:10.1210/en.2017-00663

Tateno K, Ogawa R, Sakamoto R, Tsuchiya M, Kutsumura N, Otani T, Ono K, Kawai H, Saito T (2018) Dibenzopyrrolo[1,2-a][1,8]naphthyridines: Synthesis and Structural Modification of Fluorescent L-Shaped Heteroarenes. J Org Chem. 83(2):690-702. doi:10.1021/acs.joc.7b02674

Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M (2018) The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice. Behav Brain Res. 336:77-84. doi:10.1016/j.bbr.2017.08.041

Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M, Nishino S, Shimizu T (2018) Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation. Neuropsych Dis Treat. 14:1281-1286. doi:10.2147/NDT.S158865

Liguori G, Tafuri S, Miyoshi C, Yanagisawa M, Squillacioti C, De Pasquale V, Mirabella N, Vittoria A, Costagliola A (2018) Localization of orexin B and orexin-2 receptor in the rat epididymis. ACTA Histochem. 120(3):292-297. doi:10.1016/j.acthis.2018.02.011

Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K, Uemura S, Shimizu T (2018) Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness. Neuropsych Dis Treat. 14:451-457. doi:10.2147/NDT.S158651

Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S (2018) Transcription factor MafB may play an important role in secondary hyperparathyroidism. Kidney Int. 93(1):54-68. doi:10.1016/j.kint.2017.06.023

Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2018) Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant feature. Pathol Int. 68(1):12-22. doi:10.1111/pin.12612.

Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, Nagase H (2018) Synthesis of Novel 1,3-Dioxa-5-thiazatriquinane and 1-Oxa-3,5-dithiazatriquinane Derivatives and their Pharmacologies. Heterocycles. 97:687-695. doi: 10.3987/COM-18-S(T)40

Honjoh S, Ihara A, Kajiwara Y, Yamamoto T, Nishida E (2017) The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans. Cell Rep 21(13): 3646–3652. doi:10.1016/j.celrep.2017.11.108

Liu J, Zhang MQ, Wu X, Lazarus M, Cherasse Y, Yuan MY, Huang ZL, Li RX (2017) Activation of Parvalbumin Neurons in the Rostro-Dorsal Sector of the Thalamic Reticular Nucleus Promotes Sensitivity to Pain in Mice. Neuroscience 16(366): 113-123. doi:10.1016/j.neuroscience.2017.10.013

Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T (2017) Prostaglandin D-2 metabolite in urine is an index of food allergy. Sci Rep 7(1): 17687. doi:10.1038/s41598-017-17798-w

Ogawa Y, Kanda T, Vogt K, Yanagisawa M (2017) Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates. J. Comp. Neurol. 525(18): 3809-3820. doi:10.1002/cne.24261

Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB (2017) A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron 96(5): 1153-1167. doi:10.1016/j.neuron.2017.10.009

Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y (2017) Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction. FEBS Lett. 591(24): 4067-4073. doi:10.1002/1873-3468.12914

Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y, Fujii R, Usui T, Kulathunga K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T, Takahashi S (2017) MafB is a critical regulator of complement component C1q. Nat. Commun. 8(1): 1700. doi:10.1038/s41467-017-01711-0

Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017) Orexin modulates behavioral fear expression through the locus coeruleus. Nat. Commun. 8(1): 1606. doi:10.1038/s41467-017-01782-z

Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S (2017) T cells upon activation promote endothelin 1 production in monocytes via IFN-gamma and TNF-alpha. Sci Rep 7(1): 14500. doi:10.1038/s41598-017-14202-5

Um MY, Kim S, Jin YH, Yoon M, Yang H, Lee J, Jung J, Urade Y, Huang ZL, Kwon S, Cho S (2017) A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H-1 receptors. Mol. Nutr. Food. Res. 61(11). doi:10.1002/mnfr.201700316

Kutsumura N, Shibuya K, Yamaguchi H, Saito T (2017) n-Butyllithium-promoted regioselective elimination of vicinal bis-triflate having an adjacent ether oxygen. Tetrahedron Lett. 58(43): 4099–4102. doi:10.1016/j.tetlet.2017.09.036

Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M (2017) Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development 144(20): 3706-3718. doi:10.1242/dev.150755

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Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M (2016) Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc. Natl. Acad. Sci. U.S.A. 113(21): 6023-6028. doi:10.1073/pnas.1518658113

Tsuneki H, Nagata T, Fujita M, Kon K, Wu NZ, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T (2016) Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. Endocrinology 157(1): 195-206. doi:10.1210/en.2015-1488

Nakagawa Y, Satoh A, Tezuka H, Han S, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H (2016) CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPAR alpha. Sci Rep 6: 39182. doi:10.1038/srep39182

Sunaga H, Matsui H, Anjo S, Syamsunarno MRAA, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M (2016) Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kruppel-Like Factor 4 (AMPK/KLF4) Signaling. J. Am. Heart Assoc. 5(12): e004014. doi: 10.1161/JAHA.116.004014

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H (2016) Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Mol. Metab. 5(11): 1092-1102. doi:10.1016/j.molmet.2016.09.004

Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H (2016) Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. PLoS One 11(7): e0159375. doi:10.1371/journal.pone.0159375

Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han S, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H (2016) Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced NonAlcoholic Fatty Liver Disease in Mice. PLoS One 11(6): e0157580. doi:10.1371/journal.pone.0157580

Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han S, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H (2016) Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Sci Rep 6: 27857. doi:10.1038/srep27857

Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T (2016) Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with or without midbrain involvement A case series. Medicine(Baltimore) 95(29): e4281. doi:10.1097/MD.0000000000004281

Omokawa M, Ayabe T, Nagai T, Imanishi A, Omokawa A, Nishino S, Sagawa Y, Shimizu T, Kanbayashi T (2016) Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome. Am. J. Med. Genet. A 170(5): 1181-1186. doi:10.1002/ajmg.a.37542

Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M (2016) Peripherally administered orexin improves survival of mice with endotoxin shock. eLife 5: e21055. doi:10.7554/eLife.21055

Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M (2016) Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS One 11(7): e0159246. doi:10.1371/journal.pone.0159246

Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F (2016) Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice. Exp. Anim. 65 (3): 319-327. doi:10.1538/expainm.16-0016

Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, ElShemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F (2016) Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54(7): 389-397. doi:10.1002/dvg.22944

Tran MTN, Hamada M, Nakamura M, Jeon H, Kamei R, Tsunakawa Y, Kulathunga K, Lin YY, Fujisawa K, Kudo T, Takahashi S (2016) MafB deficiency accelerates the development of obesity in mice. FEBS Open Bio 6(6): 540-547. doi:10.1002/2211-5463.12058

Daassi D, Hamada M, Jeon H, Imamura Y, Tran MTN, Takahashi S (2016) Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem. Biophys. Res. Commun. 473(1): 118-124. doi:10.1016/j.bbrc.2016.03.063

Jeon H, Waku T, Azami T, Khoa LTP, Yanagisawa J, Takahashi S, Ema M (2016) Comprehensive Identification of Kruppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming. PLoS One 11(3): e0150715. doi:10.1371/journal.pone.0150715

Abdellatif’ AM, Oishi H, Itagaki T, Jung YS, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, ElSayed MA, Shoaib MB, Sugiyama F, Takahashi S (2016) beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One 11(2): e0150010. doi:10.1371/journal.pone.0150010

Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N (2016) Overexpression of ROR gamma t Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. PLoS One 11(1): e0147064. doi:10.1371/journal.pone.0147064

Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, Murata T (2016) Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One 11(12): e0167729. doi:10.1371/journal.pone.0167729

Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A(2A) receptors. J. Sleep Res. 25(6): 746-753. doi:10.1111/jsr.12434

Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial. J. Sleep Res. 25(1): 116-123. doi:10.1111/jsr.12336

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat. Commun. 7: 11613. doi:10.1038/ncomms11613

Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS (2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 311(2): R263-R271. doi:10.1152/ajpregu.00016.2015

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight 1(11): e87860. doi:10.1172/jci.insight.87680

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A (2016) Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res. Ther. 18(1): 113. doi:10.1186/s13075-016-1011-4

Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM (2016) Functional ETA-ETB Receptor Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats. J. Cardiovasc. Pharmacol. 67(3): 212- 217. doi:10.1097/FJC.0000000000000335

Kutsumura N, Numata K, Saito T (2016) First total synthesis of haplacutine C. Tetrahedron Lett. 57(50): 5581-5583. doi:10.1016/j.tetlet.2016.10.070

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG (2016) A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol. 11(12): 3383-3390. doi:10.1021/acschembio.6b00727

Ioka S, Saitoh T, Maki SA, Imoto M, Nishiyama S (2016) Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization. Tetrahedron 72(47): 7505-7508. doi:10.1016/j.tet.2016.09.069

Honda T, Lee CY, Honjo K, Furukubo-Tokunaga K (2016) Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae. Front. Behav. Neurosci. 10: 137. doi:10.3339/fnbeh.2016.00137

Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S (2016) Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties. Chem.-Eur. J. 22(27): 9330-9337. doi:10.1002/chem.201600278

Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J (2016) OPIOID SYSTEMS IN THE LATERAL HYPOTHALAMUS REGULATE FEEDING BEHAVIOR THROUGH OREXIN AND GABA NEURONS. Neuroscience 320(183): 193 doi: 10.1016/j.neuroscience.2016.02.002

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB. The roles of prostaglandin E(2) and D(2) in lipopolysaccharide-mediated changes in sleep. Brain Behav Immun. 2014 Dec 20. pii: S0889- 1591(14)00564-9.

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014 Jun 15;522(9):2089-106.

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791-802.

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-13.

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697- 704.

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1-2):142-9.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I. Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun. 2014 Jul 18. pii: S0889- 1591(14)00400-0.

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563-77.

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and – independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

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Noriki Kutsumura, Shohei Toguchi, Masatoshi Iijima, Osamu Tanaka, Izumi Iwakura, Takao Saito, DBUpromoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups, Tetrahedron, Volume 70, Issue 43, 28 October 2014, Pages 8004-8009.

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791- 802.

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-

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Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1- 2):142-9.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563- 77.

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

Noriki K, Shohei T, Masatoshi I, Osamu T, Izumi I, Takao S. DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups. Tetrahedron. 2014 Oct 28;70:43:8004-8009.

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: The next generation. Life Sci. 2014 Aug 15.

Kashiwagi T, Fuchigami T, Saito T, Nishiyama S, Atobe M. Sequential paired electrosynthesis of a diaryl ether derivative using an electrochemical microreactor. Chem Lett. 2014 Jun 5;43(6):799-801.

Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013; 13 (6): 881-7.

Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K. Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice. G3 (Bethesda). 2013; 3 (9): 1545-52.

Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; 7: 43.

Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y. COX-2-Derived PGE2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the EP3 Receptor. Circ Res. 2013. Jul 5; 113 (2): 104-14.

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. J. Comp. Neurol. 2013.

Takase K, Oda S, Kuroda M, Funato H. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PLoS One. 2013; 8 (3): e58473.

Suzuki A, Sinton CM, Greene RW, Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 2013; 110 (25): 10288-93.

Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis. Endocrinology. 2013; 154 (10): 3577-88.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013; 4: 2883.

Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka T. Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab. 2013; 305 (11): E1415-25.

Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 2013; 4: 2563.

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T. Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice. PLoS One. 2013; 8 (7): e70012.

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. PLoS One. 2013; 8 (4): e62391.

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T. Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. J Neurosci. 2013; 33 (36): 14549-57.

Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M. κ Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Scientific Reports. 2013; 3: 3213.

Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H. The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists. Bioorg Med Chem. 2013; 21 (24): 7628-47.

Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013; 155 (6): 1323-36.