ResearchResearch Articles

2022

2022 Full list of publication

1

Ikeda Y, Morita E, Muroi K, Arai, Y, Ikeda, T, Takahashi T, Shiraki N, Doki S, Hori D, Oi Y, Sasahara S, Ishihara A, Matsumoto S, Yanagisawa M, Satoh M, Matsuzaki I (2022) Relationships between sleep efficiency and lifestyle evaluated by objective sleep assessment: Sleep Epidemiology Project at University of Tsukuba. Nagoya J. Med. Sci. 84(3):554-569. doi:10.18999/nagjms.84.3.554

2

Fifel K, Deboer T (2022) Heterogenous electrophysiological responses of functionally distinct striatal subregions to circadian and sleep-related homeostatic processes. Sleep 45(1). doi:10.1093/sleep/zsab230

3

Park I, Kokudo C, Seol J, Ishihara A, Zhang SM, Uchizawa A, Osumi H, Miyamoto R, Horie K, Suzuki C, Suzuki Y, Okura T, Diaz J, Vogt KE, Tokuyama K (2022) Instability of non-REM sleep in older women evaluated by sleep-stage transition and envelope analyses. Front. Aging Neurosci. 14. doi:10.3389/fnagi.2022.1050648

4

Hori D, Arai Y, Morita E, Ikeda Y, Muroi K, Ishitsuka M, Ikeda T, Takahashi T, Doki S, Oi Y, Sasahara S, Ishihara A, Matsumoto S, Kanbayashi T, Yanagisawa M, Satoh M (2022) Morning preference is associated with subjective happiness among Japanese female workers: A moderation analysis by sleep characteristics from the SLEPT study. Chronobiol. Int. 39(5):690-703. doi:10.1080/07420528.2022.2028801

5

Nemoto T, Irukayama-Tomobe Y, Hirose Y, Tanaka H, Takahashi G, Takahashi S, Yanagisawa M, Kanbayashi T (2022) Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide. J. Sleep Res. 31(5). doi:10.1002/advs.202203170

6

Fifel K, Yanagisawa M, Deboer T (2022) Mechanisms of sleep/wake regulation under hypodopaminergic state: Insights from MitoPark mouse model of Parkinson’s disease. Adv. Sci. 10(5). doi:10.1002/advs.202203170

7

Fujiyama T, Takenaka H, Asano F, Miyanishi K, Hotta-Hirashima N, Ishikawa Y, Kanno S, Seoane-Collazo P, Miwa H, Hoshino M, Yanagisawa M, Funato H (2022) Mice lacking cerebellar cortex and related structures show a decrease in slow-wave activity with normal non-REM sleep amount and sleep homeostasis. Front. Behav. Neurosci. 16. doi:10.3389/fnbeh.2022.910461

8

Fifel K, El Farissi A, Cherasse Y, Yanagisawa M (2022) Motivational and valence-related modulation of sleep/wake behavior are mediated by midbrain dopamine and uncoupled from the homeostatic and circadian processes. Adv. Sci. 9(24). doi:10.1002/advs.202200640

9

Han G, Matsumoto S, Diaz J, Greene RW, Vogt KE (2022) Dihydropyridine calcium blockers do not interfere with non-rapid eye movement sleep. Front. Neurosci. 16. doi:10.3389/fnins.2022.969712

10

Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato TA, Funato H, Yanagisawa M (2022) Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Neurosci. Res. 177:16-24. doi:10.1016/j.neures.2021.11.008

11

Bjorness TE, Greene RW (2022) Arousal-mediated sleep disturbance persists during cocaine abstinence in male mice. Front. Neurosci. 16. doi:10.3389/fnins.2022.868049

12

Xu JJ, Zhou R, Wang GD, Guo Y, Gao X, Zhou S, Ma CY, Chen L, Shi BH, Wang HY, Wang FC, Liu, Q (2022) Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinas5. Sleep 45(11). doi:10.1093/sleep/zsac198

13

Wang GD, Li Q, Xu JJ, Zhao S, Zhou R, Chen ZK, Jiang WT, Gao X, Zhou S, Chen ZY, Sun QZ, Ma CY, Chen L, Shi BH, Guo Y, Wang HY, Wang X, Li HY, Cai T, Wang YB, Chen ZN, Wang FC, Liu QH (2022) Somatic genetics analysis of sleep in adult mice. J. Neurosci. 42(28):5617-5640. doi:10.1523/JNEUROSCI.0089-22.2022

14

Adachi M, Nagaura Y, Eto H, Kondo H, Kato C (2022) The impact of sleep-wake problems on health-related quality of life among Japanese nursing college students: a cross sectional survey. Health Qual. Life Outcomes 20(1). doi:10.1186/s12955-022-02063-0

15

Miyazaki S, Kawano T, Yanagisawa M, Hayashi Y (2022) Intracellular Ca2+ dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans. iScience 25(6). doi:10.1016/j.isci.2022.104452

16

Hasegawa E, Miyasaka A, Sakurai K, Cherasse Y, Li YL, Sakurai T (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science 375(6584):994-1000. doi:10.1126/science.abl6618

17

Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T (2022) Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: A randomized, double-blind placebo-controlled study. Nutrients 14(4). doi:10.3390/nu14040755

18

Zhou R, Wang GD, Li Q, Meng FX, Liu C, Gan R, Ju DP, Liao MM, Xu JJ, Sang D, Gao X, Zhou S, Wu KJ, Sun QZ, Guo Y, Wu CY, Chen ZY, Chen L, Shi BH, Wang HY, Wang X, Li HY, Cai T, Li B, Wang FC, Funato H, Yanagisawa M, Zhang EE, Liu QH (2022) A signalling pathway for transcriptional regulation of sleep amount in mice. Nature 612(7940):519-527. doi:10.1038/s41586-022-05510-6

19

Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki, S, Tsuneoka, Y, Sugiyama, F, Takahashi, S, Hayashi, Y, Muratani, M, Liu, Q, Miyoshi, C, Yanagisawa M, Funato H (2022) Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature 612 (7940):512-518. doi:10.1038/s41586-022-05450-1

20

Chen ZK, Dong H, Liu CW, Liu WY, Zhao YN, Xu W, Sun X, Xiong YY, Liu YY, Yuan XS, Wang B, Lazarus M, Cherasse Y, Li YD, Han F, Qu WM, Ding FF, Huang ZL (2022) A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discov. 8(1):115. doi:10.1038/s41421-022-00456-5

21

Tone D, Ode KL, Zhang QH, Fujishima H, Yamada RG, Nagashima Y, Matsumoto K, Wen ZQ, Yoshida SY, Mitani TT, Arisato Y, Ohno R, Ukai-Tadenuma M, Garcon JY, Kaneko M, Shi, S, Ukai H, Miyamichi K, Okada T, Sumiyama K, Kiyonari H, Ueda HR (2022) Distinct phosphorylation states of mammalian CaMKII beta control the induction and maintenance of sleep. PLoS. Biol. 20(10). doi:10.1371/journal.pbio.3001813

22

Uemura SI, Imanishi A, Terui Y, Park I, Satake M, Han G, Shioya T, Kanbayashi T, Nishino S (2022) Residual effects of low dose of suvorexant, zolpidem, and ramelteon in healthy elderly subjects: A randomized double-blind study. Neuropsychopharmacol. Rep. 42(3):288-298. doi:10.1002/npr2.12262

23

Ogawa T, Kajiyama Y, Ishido H, Chiba S, Revankar GS, Nakano T, Taniguchi S, Kanbayashi T, Ikenaka K, Mochizuki H (2022) Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson’s disease: A retrospective study. PLoS One 17(12). doi:10.1371/journal.pone.0279747

24

Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M (2022) OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy. PLoS One 17(7). doi:10.1371/journal.pone.0271901

25

Korkutata M, Agrawal L, Lazarus M (2022) Allosteric modulation of adenosine A(2A) receptors as a new therapeutic avenue. Int. J. Mol. Sci. 23(4):128-130. doi:10.3390/ijms23042101

26

Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H, Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y, Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T, Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of idiopathic hypersomnia in a Japanese population. Sleep Biol. Rhythms 20(1):137-148. doi:10.1007/s41105-021-00349-2

27

Choi YJ, Nakamura Y, Akazawa N, Park, I, Kwak HB, Tokuyama K, Maeda S (2022) Effects of nocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover trial. Chronobiol. Int. 39(4):602-612. doi:10.1080/07420528.2021.2014517

28

Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T (2022) Optogenetic induction of hibernation-like state with modified human Opsin4 in mice. Cell Reports Methods 2(11). doi:10.1016/j.crmeth.2022.100336

29

Nagayama M, Aritake T, Hino H, Kanda T, Miyazaki T, Yanagisawa M, Akah, S, Murata N (2022) Detecting cell assemblies by NMF-based clustering from calcium imaging data. Neural Netw. 149:29-39. doi:10.1016/j.neunet.2022.01.023

30

Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yangisawa M, Nagase H (2022) Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatri-quinane bearing multiple effective residues (TriMER) library. Eur. J. Med. Chem. 240. doi:10.1016/j.ejmech.2022.114505

31

Miyagawa T, Tanaka S, Shimada M, Sakai N, Tanida K, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kanbayashi T, Imanishi A, Ikegami A, Kamei Y, Hida A, Wada Y, Miyamoto M, Takami M, Kondo H, Tamura Y, Taniyama Y, Omata N, Mizuno T, Moriya S, Furuya H, Kato M, Kato K, Ishigooka J, Tsuruta K, Chiba S, Yamada N, Okawa M, Hirata K, Kuroda K, Kume K, Uchimura N, Kitada M, Kodama T, Inoue Y, Nishino S, Mishima K, Tokunaga K, Honda M (2022) A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia. npj Genom. Med. 7(1). doi:10.1038/s41525-022-00298-w

32

Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H (2022) Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Bioorg. Med. Chem. Lett. 60. doi:10.1016/j.bmcl.2022.128555

33

Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli J (2022) Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson’s disease. Adv. Sci. 9(10). doi:10.1002/advs.202103827

34

Tsuneoka Y, Atsumi Y, Makanae A, Yashiro M, Funato H (2022) Fluorescence quenching by high-power LEDs for highly sensitive fluorescence in situ hybridization. Front. Molec. Neurosci. 15. doi:10.3389/fnmol.2022.976349

35

Yamada T, Shi S (2022) Estimating infection-related human mobility networks based on time series data of COVID-19 infection in Japan. Appl. Sci.-Basel 12(18). doi:10.3390/app12189236

36

Iio K, Kutsumura N, Nagumo Y, Saitoh T, Tokuda A, Hashimoto K, Yamamoto N, Kise R, Inoue A, Mizoguchi H, Nagase H (2022) Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands. Bioorg. Med. Chem. Lett. 56. doi:10.1016/j.bmcl.2021.128485

37

Hino T, Saitoh T, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H (2022) Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton. Bioorg. Med. Chem. Lett. 59. doi:10.1016/j.bmcl.2022.128530

38

Katoh K, Kutsumura N, Yamamoto N, Nagumo Y, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y, Tanimura R, Yanagisawa M, Nagase H (2022) Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives. Bioorg. Med. Chem. Lett. 59. doi:10.1016/j.bmcl.2022.128550

39

Moctezuma LA, Abe T, Molinas M (2022) Two-dimensional CNN-based distinction of human emotions from EEG channels selected by multi-objective evolutionary algorithm. Sci. Rep 12(1). doi:10.1038/s41598-022-07517-5

40

Shimazaki K, Sugimoto T, Toda H, Takahashi H (2022) A polyimide film-based simple force plate for measuring the body mass of tiny insects. Sensors 22(21). doi:10.3390/s22218352

41

Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii KA, Tanaka T, Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T (2022) Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes. J. Diabetes Investig. 13(3):532-542. doi:10.1111/jdi.13699

42

Kawaminami A, Yamada D, Yanagisawa S, Shirakata M, Iio K, Nagase H, Saitoh A (2022) Selective delta-opioid receptor agonist, KNT-127, facilitates contextual fear extinction via infralimbic cortex and amygdala in mice. Front. Behav. Neurosci. 16. doi:10.3389/fnbeh.2022.808232

43

Omichi C, Kaminishi Y, Kadotani H, Sumi Y, Ubara A, Nishikawa K, Matsuda A, Ozeki Y (2022) Limited social support is associated with depression, anxiety, and insomnia in a Japanese working population. Front. Public Health 10. doi:10.3389/fpubh.2022.981592

44

Kitano M, Saitoh T, Nishiyama S, Einaga Y, Yamamoto T (2022) Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes. Beilstein J. Org. Chem. 18:1154-1158. doi:10.3762/bjoc.18.119

45

Uenohara Y, Tsumura S, Hirayama S, Higashi E, Watanabe Y, Gouda H, Nagase H, Fujii H (2022) Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward delta and Kappa opioid receptors. Bioorg. Med. Chem. 53. doi:10.1016/j.bmc.2021.116552

46

Okamura H, Yasugaki S, Suzuki-Abe H, Arai Y, Sakurai K, Yanagisawa M, Takizawa H, Hayashi Y (2022) Long-term effects of repeated social defeat stress on brain activity during social interaction in BALB/c mice. eNeuro 9(3). doi:10.1523/ENEURO.0068-22.2022

47

Shaikh SA, Kitagawa H, Matono A, Mariam K, Kim KS (2022) GeoFlink: An efficient and scalable spatial data stream management system. IEEE Access 10:24909-24935. doi:10.1109/ACCESS.2022.3154063

48

Tao XX, Zhang R, Du RL, Yu TT, Yang H, Li JW, Wang YH, Liu Q, Zuo SK, Wang X, Lazarus M, Zhou L, Wang BM, Yu Y, Shen YJ (2022) EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model. J. Exp. Med. 219(5). doi:10.1084/jem.20212414

49

Sugimoto T, Kawasaki Y, Toda H, Takahashi H (2022) Measurement method of a microspring-supported force plate with an external laser displacement meter. Meas. Sci. Technol. 33(10). doi:10.1088/1361-6501/ac7b12

50

Nakauchi Y, Nishinami S, Murakami Y, Ogura T, Kano H, Shiraki K (2022) Opalescence arising from network assembly in antibody solution. Mol. Pharm. 19(4):1160-1167. doi:10.1021/acs.molpharmaceut.1c00929

51

Katoh K, Yamamoto N, Ishikawa Y, Irukayama-Tomobe Y, Tanimura R, Saitoh T, Nagumo Y, Kutsumura N, Yanagisawa M, Nagase H (2022) Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epox-ymorphinan derivatives for orexin and opioid receptors. Bioorg. Med. Chem. Lett. 59. doi:10.1016/j.bmcl.2022.128527

52

Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N (2022) Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis. Psychopharmacology 239(2):525-531. doi:10.1007/s00213-021-06036-x

53

Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H (2022) Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. Biomed. Opt. Express 13(2):694-708 doi:10.1364/BOE.446273

54

Hinotsu K, Miyaji C, Yada Y, Kawai H, Sakamoto S, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K, Takao S, Kishi Y, Takaki M, Yamada N (2022) The validity of atypical psychosis diagnostic criteria to detect anti-NMDA receptor encephalitis with psychiatric symptoms. Schizophr. Res. 248:292-299. doi:10.1016/j.schres.2022.08.024

55

Yamada M, Kitagawa H, Amagasa T, Matono A (2022) Augmented lineage: traceability of data analysis including complex UDF processing. VLDB J. doi:10.1007/s00778-022-00769-7

56

Yamauchi T, Yoshioka T, Yamada D, Hamano T, Ohashi M, Matsumoto M, Iio K, Ikeda M, Kamei M, Otsuki T, Sato Y, Nii K, Suzuki M, Ichikawa H, Nagase H, Iriyama S, Yoshizawa K, Nishino S, Miyazaki S, Saitoh A (2022) Cold-restraint stress-induced ultrasonic vocalization as a novel tool to measure anxiety in mice. Biol. Pharm. Bull. 45(3):268-275.

57

Li YD, Luo YJ, Chen ZK, Quintanilla L, Cherasse Y, Zhang LB, Lazarus M, Huang ZL, Song J (2022) Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nat. Neurosci. 25(5):630–645. doi:10.1038/s41593-022-01065-x

58

Yamazaki S, Inohara N, Ohmuraya M, Tsuneoka Y, Yagita H, Katagiri T, Nishina T, Mikami T, Funato H, Araki K, Nakano H (2022) I kappa B zeta controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies. Mucosal Immunol. 15(8):1321-1337. doi:10.1038/s41385-022-00554-3

59

Tao XX, Du RL, Guo SM, Feng XL, Yu TT, OuYang Q, Chen QL, Fan XT, Wang XQ, Guo C, Li XZ, Xue FX, Chen S, Tong MH, Lazarus M, Zuo SK, Yu Y, Shen YJ (2022) PGE(2)-EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. Embo J. 41(16). doi:10.15252/embj.2021110439

60

Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ (2022) Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nat. Commun. 13(1):4089. doi:10.1038/s41467-022-31728-z

61

Horie K, Ota L, Miyamoto R, Abe T, Suzuki Y, Kawana F, Kokubo T, Yanagisawa M, Kitagawa H (2022) Automated sleep stage scoring employing a reasoning mechanism and evaluation of its explainability. Sci. Rep. 12(1):12799. doi:10.1038/s41598-022-16334-9

62

Bou S, Kitagawa H, Amagasa T (2022) CPiX: Real-time analytics over out-of-order data streams by incremental sliding-window aggregation. IEEE Transactions on Knowledge and Data Engineering 34(11):5239-5250. doi:10.1109/TKDE.2021.3054898

63

Miura K, Kobayashi R, Amagasa T, Kitagawa H, Fujita N, Boku T (2022) An FPGA-based accelerator for regular path queries over edge-labeled graphs. Proc. IEEE BigData2022:415-422. doi:10.1109/BigData55660.2022.10020406

64

Takdir, Kitagawa H, Amagasa T (2022) Region-based sub-snapshot (RegSnap): Enhanced fault tolerance in distributed stream processing with partial snapshot. Proc. 7th Workshop on Real-time Stream Analytics, Stream Mining, CER/CEP & Stream Data Management in Big Data:3374-3382. doi:10.1109/BigData55660.2022.10020607

65

Shaikh S A, Kitagawa H, Matono A, Kim K S (2022) TStream: A framework for real-time and scalable trajectory stream processing and analysis. Proc. ACM SIGSPATIAL 2022:30. doi:10.1145/3557915.3560964

66

Seol J, Lee J, Park I, Tokuyama K, Fukusumi S, Kokubo T, Yanagisawa M, Okura T (2022) Bidirectional associations between physical activity and sleep in older adults: a multilevel analysis using polysomnography. Sci. Rep. 12(1):15399. doi:10.1038/s41598-022-19841-x

67

Uchizawa A, Funayama A, Osumi H, Enomoto Y, Zhang S, Tokuyama K, Omi N, Sagayama H (2022) Food quotient assessments using one-week dietary records and food frequency questionnaires of young Japanese runners. J. Nutr. Sci. Vitaminol. 68(1):47-54. doi: 10.3177/jnsv.68.47

68

Koyama K, Ito MK, Sakaguchi M, Ohnishi T (2022) Classification of power spectra of EEG by non-negative matrix factorization. Technical Report of IEICE 121:111-116.

69

Koyanagi I, Tezuka T, Yu J, Srinivasan S, Naoi T, Yasugaki S, Nakai A, Taniguchi S, Hayashi Y, Nakano Y, Sakaguchi M (2022) Fully automatic REM sleep stage-specific intervention systems using single EEG in mice. Neurosci. Res. 186:51-58. doi:10.1016/j.neures.2022.10.001

70

Funato H, Yanagisawa M (2022) Hunt for mammalian sleep-regulation genes. Brain Sci. Adv. 8(3):173–182. doi:10.26599/BSA.2022.9050012

71

Ando T, Wakai M, Kanbayashi T, Katsuno M (2022) Status cataplecticus with rapid eye movement sleep excess in late-onset narcolepsy type 1. Intern. Med. 61(19):2951-2955. doi:10.2169/internalmedicine.8465-21

2021

2021年 Full list of publication

1

Suzuki Y, Kawana F, Satoh M, Abe T (2021) The abrupt shift to slower frequencies after arousal from sleep in healthy young adults. Journal of Clinical Sleep Medicine 17(12): 2373-2381. doi:10.5664/jcsm.9434

2

Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato TA, Sakaguchi M (2021) Metabolic fingerprints of fear memory consolidation during sleep. Molecular Brain 14(1). doi:10.1186/s13041-021-00733-6

3

Iwasaki K, Fujiyama T, Nakata S, Park M, Miyoshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M, Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M (2021) Induction of mutant Sik3(Sleepy) allele in neurons in late infancy increases sleep need. Journal of Neuroscience 41(12): 2733-2746. doi:10.1523/JNEUROSCI.1004-20.2020

4

Choi J, Kim SJ, Fujiyama T, Miyoshi C, Park M, Suzuki-Abe H, Yanagisawa M, Funato H (2021) The role of reproductive hormones in sex differences in sleep homeostasis and arousal response in mice. Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.739236

5

Kashiwagi M, Kanuka M, Tanaka K, Fujita M, Nakai A, Tatsuzawa C, Kobayashi K, Ikeda K, Hayashi Y (2021) Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice. Molecular Brain 14(1). doi:10.1186/s13041-021-00879-3

6

Gao TX, Li JY, Watanabe Y, Hung CJ, Yamanaka A, Horie K, Yanagisawa M, Ohsawa M, Kume K (2021) GI-SleepNet: A highly versatile image-based sleep classification using a deep learning algorithm. Clocks & Sleep 3(4): 581-597. doi:10.3390/clockssleep3040041

7

Zhang SM, Tanaka Y, Ishihara A, Uchizawa A, Park I, Iwayama K, Ogata H, Yajima K, Omi N, Satoh M, Yanagisawa M, Sagayama H, Tokuyama K (2021) Metabolic flexibility during sleep. Scientific Reports 11(1). doi:10.1038/s41598-021-97301-8

8

Uchida S, Soya S, Saito YC, Hirano A, Koga K, Tsuda M, Abe M, Sakimura K, Sakurai T (2021) A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice. Journal of Neuroscience 41(7): 1582-1596. doi:10.1523/JNEUROSCI.0688-20.2020

9

Tezuka T, Kumar D, Singh S, Koyanagi I, Naoi T, Sakaguchi M (2021) Real-time, automatic, open-source sleep stage classification system using single EEG for mice. Scientific Reports 11(1). doi:10.1038/s41598-021-90332-1

10

Liu CY, Tsai CJ, Yasugaki S, Nagata N, Morita M, Isotani A, Yanagisawa M, Hayashi Y (2021) Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neuroscience Research 14-25. doi:10.1016/j.neures.2020.04.002

11

Park I, Diaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh M, Tokuyama K, Vogt KE (2021) Exercise improves the quality of slow-wave sleep by increasing slow-wave stability. Scientific reports 11(1). doi:10.1038/s41598-021-83817-6

12

Kaushik MK, Aritake K, Cherasse Y, Imanishi A, Kanbayashi T, Urade Y, Yanagisawa M (2021) Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice. Sleep 44(8). doi:10.1093/sleep/zsab043

13

Uchizawa A, Hibi M, Sagayama H, Zhang SM, Osumi H, Tanaka Y, Park I, Tokuyama K, Omi N (2021) Novel equations to estimate resting energy expenditure during sitting and sleeping. Annals of Nutrition and Metabolism 77(3): 159-167. doi:10.1159/000516174

14

Seol J, Park I, Kokudo C, Zhang SM, Suzuki C, Yajima K, Satoh M, Tokuyama K, Okura T (2021) Distinct effects of low-intensity physical activity in the evening on sleep quality in older women: A comparison of exercise and housework. Experimental Gerontology 143. doi:10.1016/j.exger.2020.111165

15

Suzuki F, Morita E, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kannon T, Tajima A, Matsumoto S, Ishihara A, Hori D, Doki S, Oi Y, Sasahara S, Satoh M, Matsuzaki I, Yanagisawa M, Ikaga T, Nakamura H (2021) Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study. PLOS ONE 16(2). doi:10.1371/journal.pone.0247926

16

Seol J, Lee J, Nagata K, Fujii Y, Joho K, Tateoka K, Inoue T, Liu J, Okura T (2021) Combined effect of daily physical activity and social relationships on sleep disorder among older adults: cross-sectional and longitudinal study based on data from the Kasama study. BMC Geriatrics 21(1). doi:10.1186/s12877-021-02589-w

17

Yang YF, Dong H, Shen Y, Li L, Lazarus M, Qu WM, Huang ZL (2021) Mesencephalic dopamine neurons are essential for modafinil-induced arousal. British Journal of Pharmacology 178(24): 4808-4825. doi:10.1111/bph.15660

18

Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H, Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y, Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T, Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of idiopathic hypersomnia in a Japanese population. Sleep and Biological Rhythms 20(1): 137-148. doi:10.1007/s41105-021-00349-2

19

Kaneko Y, Inoue Y, Fujiki N, Han G, Nishino S, Shimizu T, Kanbayashi T, Kondo H (2021) The anticataplectic and REM suppression effect of milnacipran, an SNRI, on human and canine narcolepsy. Sleep and Biological Rhythms 19(2): 137-143. doi:10.1007/s41105-020-00298-2

20

Ishihara A, Park I, Suzuki Y, Yajima K, Cui H, Yanagisawa M, Sano T, Kido J, Tokuyama K (2021) Metabolic responses to polychromatic LED and OLED light at night. Scientific reports 11(1). doi:10.1038/s41598-021-91828-6

21

Saito R, Miyoshi C, Koebis M, Kushima I, Nakao K, Mori D, Ozaki N, Funato H, Yanagisawa M, Aiba A (2021) Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. Molecular Brain 14(1). doi:10.1186/s13041-021-00778-7

22

Choi YJ, Nakamura Y, Akazawa N, Park I, Kwak HB, Tokuyama K, Maeda S (2022) Effects of nocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover trial. Chronobiology International 39(4): 602-612. doi:10.1080/07420528.2021.2014517

23

Vergara P, Kumar D, Srinivasan S, Koyanagi I, Naoi T, Singh S, Sakaguchi M (2021) Remapping of adult-born neuron activity during fear memory consolidation in mice. International Journal of Molecular Sciences 22(6). doi:10.3390/ijms22062874

24

Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL (2021) Medial parabrachial nucleus is essential in controlling wakefulness in rats. Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.645877

25

Inagawa Y, Shimizu S, Takenoshita n, Tsugawa A, Hirose D, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H, Kanetaka H, Hirao K (2021) Association between cerebrospinal fluid Orexin A level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies. Psychogeriatrics 21(1): 128-130. doi:10.1111/psyg.12618

26

Li YD, Luo YJ, Xu W, Ge J, Cherasse Y, Wang YQ, Lazarus M, Qu WM, Huang ZL (2021) Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Molecular Psychiatry 26(7): 2912-2928. doi:10.1038/s41380-020-00906-0

27

Miyanishi K, Sato A, Kihara N, Utsunomiya R, Tanaka J (2021) Synaptic elimination by microglia and disturbed higher brain functions. Neurochemistry International 142. doi:10.1016/j.neuint.2020.104901

28

Yu JH, Naoi T, Sakaguchi M (2021) Fear generalization immediately after contextual fear memory consolidation in mice. Biochemical and Biophysical Research Communications 102-106. doi:10.1016/j.bbrc.2021.04.072

29

Tanaka Y, Ogata H, Park I, Ando A, Ishihara A, Kayaba M, Yajima K, Suzuki C, Araki A, Osumi H, Zhang SM, Seol J, Takahashi K, Nabekura Y, Satoh M, Tokuyama K (2021) Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men. Physiological Reports 9(7). doi:10.14814/phy2.14784

30

Liu C, Lee CY, Asher G, Cao LQ, Terakoshi Y, Cao P, Kobayakawa R, Kobayakawa K, Sakurai K, Liu QH (2021) Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice. Nature Communications 12(1). doi:10.1038/s41467-021-22914-6

31

Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii KA, Tanaka T, Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T (2022) Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes. Journal of Diabetes Investigation 13(3): 532-542. doi:10.1111/jdi.13699

32

Yamamoto T, Saitoh T, Einaga Y, Nishiyama S (2021) Anodic oxidation of phenols: A key step for the synthesis of natural products. Chemical Record 21(9): 2254-2268. doi:10.1002/tcr.202100032

33

Noorani SK, Hojati V, Akbari E, Ehsani S, Sakurai T, Ardeshiri MR (2021) The role of interaction between orexin receptors and beta 2 adrenergic receptors in basolateral amygdala in dentate gyrus synaptic plasticity in male rats. Brain Research Bulletin 164-171. doi:10.1016/j.brainresbull.2021.09.020

34

Maejima T, Tsuno Y, Miyazaki S, Tsuneoka Y, Hasegawa E, Islam MT, Enoki R, Nakamura TJ, Mieda M (2021) GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior. PNAS 118(6). doi:10.1073/pnas.2010168118

35

Yamada D, Takahashi J, Iio K, Nagase H, Saitoh A (2021) Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice. Biochemical and Biophysical Research Communications 192-198. doi:10.1016/j.bbrc.2021.05.002

36

Bittar TP, Pelaez MC, Silva JCH, Quessy F, Lavigne AA, Morency D, Blanchette LJ, Arsenault E, Cherasse Y, Seigneur J, Timofeev I, Sephton CF, Proulx CD, Labonte B (2021) Chronic stress induces sex-specific functional and morphological alterations in corticoaccumbal and corticotegmental pathways. Biological Psychiatry 90(3): 194-205. doi:10.1016/j.biopsych.2021.02.014

37

Sakamoto K, Yamada D, Yamanaka N, Nishida M, Iio K, Nagase H, Saitoh A (2021) A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. Brain Research 1757. doi:10.1016/j.brainres.2021.147297

38

Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJM (2021) Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. PNAS 118(12). doi:10.1073/pnas.2005753118

39

Matsuo T, Isosaka T, Hayashi Y, Tang LJ, Doi A, Yasuda A, Hayashi M, Lee CY, Cao LQ, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu QH, Kobayakawa R, Kobayakawa K (2021) Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nature Communications 12(1). doi:10.1038/s41467-021-22205-0

40

Nagata K, Nagase H, Okuzumi A, Nishiyama C (2021) Delta opioid receptor agonists ameliorate colonic inflammation by modulating immune responses. Frontiers in Immunology 12. doi:10.3389/fimmu.2021.730706

41

Ohrui S, Irukayama-Tomobe Y, Ishikawa Y, Yanagisawa M, Nagase H (2021) Design and synthesis of novel orexin antagonists via structural simplification of the morphinan skeleton. Heterocycles 103(2): 929-951. doi:10.3987/COM-20-S(K)63

42

Hino T, Kutsumura N, Saitoh T, Yamamoto N, Nagumo Y, Mogi Y, Watanabe Y, Nagase H (2021) Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives. Tetrahedron Letters 63. doi:10.1016/j.tetlet.2020.152714

43

Yu LY, Tseng TJ, Lin HC, Hsu CL, Lu TX, Tsai CJ, Lin YC, Chu I, Peng CT, Chen HJ, Tsai FC (2021) Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration. Science Advances 7(31). doi:10.1126/sciadv.abg2106

44

Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N (2022) Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis. Psychopharmacology 239(2): 525-531. doi:10.1007/s00213-021-06036-x

45

Nakagawa Y, Wang YN, Han S, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H (2021) Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition. Cellular and Molecular Gastroenterology and Hepatology 11(4): 949-971. doi:10.1016/j.jcmgh.2020.11.004

46

Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A, Nakagawa Y, Shimano H, Higami Y (2021) Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle. Experimental gerontology 154. doi:10.1016/j.exger.2021.111519

47

Ryanto GRT, Ikeda K, Miyagawa K, Tu L, Guignabert C, Humbert M, Fujiyama T, Yanagisawa M, Hirata K, Emoto N (2021) An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension. Nature communications 12(1). doi:10.1038/s41467-021-21961-3

48

Shimamoto S, Nakagawa Y, Hidaka Y, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, Ohkubo T, Aritake K, Kaushik MK, Urade Y (2021) Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase. Biochemical and biophysical research communications 66-71. doi:10.1016/j.bbrc.2021.06.092

49

Omoya R, Miyajima M, Ohta K, Suzuki Y, Aoki A, Fujiwara M, Watanabe T, Yoshida N, Suwa H, Kawara T, Takahashi H, Matsushima E, Takeuchi T (2021) Heart rate response to orthostatic challenge in patients with dementia with Lewy bodies and Alzheimer’s disease. Psychogeriatrics 21(1): 62-70. doi:10.1111/psyg.12625

50

Murata K, Mimura A, Suzuki H, Mikami N, Hamada Y, Kato K, Iki N, Ishida M, Daitoku Y, Tanimoto Y, Okiyoneda T, Fujiyama T, Dinh TTH, Mizuno S, Sugiyama F (2021) Efficient induction of proximity-dependent labelling by biotin feeding in BMAL1-BioID knock-in mice. Journal of Biochemistry 170(4): 453-461. doi:10.1093/jb/mvab059

51

Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H (2021) Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB Journal 35(6). doi:10.1096/fj.202002784RR

52

Shokirova H, Inomata T, Saitoh T, Zhu J, Fujio K, Okumura Y, Yanagawa A, Fujimoto K, Sung J, Eguchi A, Miura M, Nagino K, Hirosawa K, Kuwahara M, Akasaki Y, Nagase H, Murakami A (2021) Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation. Scientific Reports 11(1). doi:10.1038/s41598-021-88118-6

53

Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami K, Wilson V, Arkell RM, Sugiyama F (2021) Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Elife 10. doi:10.7554/eLife.50346

54

Takei Y, Hirai R, Fukuda A, Miyazaki S, Shimada R, Okamatsu-Ogura Y, Saito M, Leproux P, Hisatake K, Kano H (2021) Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator. Journal of Chemical Physics 155(12). doi:10.1063/5.0063250

55

Aso T, Amagasa T, Kitagawa H (2021) A system for relation-oriented faceted search over knowledge bases. International Journal of Web Information Systems 17(6) 698-713. doi:10.1108/IJWIS-03-2021-0035

56

Takagi H, Chen H, Furuse K, Kitagawa H (2021) Aggregate nearest neighborhood queries. Proc. FICC 2021. Advances in Intelligent Systems and Computing 1364 396–414. doi:10.1007/978-3-030-73103-8_28

57

Kato Y, Chen H, Furuse K, Kitagawa H (2021) Unifying spatial keyword indexing in continuous search on dynamic objects. Proc. FICC 2021. Advances in Intelligent Systems and Computing 1364 415–430. doi:10.1007/978-3-030-73103-8_29

58

Khalique V, Kitagawa H (2021) VOA*: Fast angle-based outlier detection over high-dimensional data streams. Proc. PAKDD 2021. Lecture Notes in Computer Science 12712 44-52. doi:10.1007/978-3-030-75762-5_4

59

Yoshimura C, Kitagawa H (2021) TLV-Bandit: Bandit method for collecting topic-related local tweets. Proc. 2021. IEEE 4th International Conference on Multimedia Information Processing and Retrieval (MIPR) 56-62. doi:1109/MIPR51284.2021.00016

60

Yamada M, Kitagawa H, Amagasa T, Matono A (2021) Augmented lineage: Traceability of data analysis including complex UDFs. Proc. DEXA 2021. Lecture Notes in Computer Science 12923 65–77. doi:10.1007/978-3-030-86472-9_6

61

Aso T, Amagasa T, Kitagawa H (2021) A method for searching documents using knowledge bases. Proc. iiWAS2021 250-258. doi:10.1145/3487664.3487699

62

Carrier-Ruiz A, Sugaya Y, Kumar D, Vergara P, Koyanagi I, Srinivasan S, Naoi T, Kano M, Sakaguchi M (2021) Calcium imaging of adult-born neurons in freely moving mice, STAR Protocols 2(1):100328, 2021Mar19. doi/10.1016/j.xpro.2020.100238

63

Tsai CJ, Nagata T, Liu CY, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M, Vogt V, Yanagisawa M, Hayashi Y (2021) Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. Cell Reports 36(7). doi:10.1016/j.celrep.2021.109558

64

Sakamoto K, Morikuni K, Sakurai T, Matsumoto S, Vogt K (2021) Online spectral classification for long-term spike sorting. 2021 5th International Conference on Medical and Health Informatics Pages 89-97

65

Park I, Díaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh M, Tokuyama K, Vogt K (2021) Exercise improves the quality of slow-wave sleep by increasing slow-wave stability. Scientific Reports 11(1). doi:10.1038/s41598-021-83817-6

66

Park I, Suzuki C, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Kokubo T, Tokuyama K, Yanagisawa M, Satoh M (2021) Effects of body pillow use on sleeping posture and sleep architecture in healthy young adults. Sleep Medicine Research 12(1): 57-63.

67

Ikeda T, Hori D, Arai Y, Muroi K, Ikeda Y, Takahashi K, Shiraki N, Doki S, Oi Y, Sasahara S, Morita E, Matsuzaki I (2021) Association between forest and greenspace walking and stress-coping skills among workers of Tsukuba Science City, Japan: a cross-sectional study. Public Health in Practice. 2021; 2: 100074

68

Sakurai T, Saito Y, Yanagisawa M (2021) Interaction between orexin neuronsand monoaminergic systems. Front Neurol Neurosci 45 11-21. doi:10.1159/000514955

69

Suzuki Y, Abe T, Kawana F, Okabe S, Kokubo T, Hoshino K, Baba M, Fujiyama M, Yanagisawa M (2021) O-EG004.Comparing the accuracy of sleep staging data from a new wearable sleep electroencephalography device versus the Fitbit Charge 3 with polysomnography as reference. Clinical Neurophysiology 132(8): 67. doi:10.1016/j.clinph.2021.02.125

70

Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato T, Funato H, Yanagisawa M (2021) Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Journal of Neuroscience Research 177 16-24. doi:10.1016/j.neures.2021.11.008

71

Iwasaki K, Hotta-Hirashima N, Funato H, Yanagisawa M (2021) Protocol for sleep analysis in the brain of genetically modified adult mice. STAR Protocols 2(4): 100982. doi: 10.106/j.xpro.2021.100982

72

Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H (2021) Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. Biomedical Optics Express 13(2): 694-708. doi: 10.1364/BOE.446273

73

Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H (2021) Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondria disease. Cell Metabolism 33:1974-1987

2020

2020 Full list of publication

1

Abe T, Mishima K, Kitamura S, Hida A, Inoue Y, Mizuno K, Kaida K, Nakazaki K, Motomura Y, Maruo K, Ohta T, Furukawa S, Dinges DF, Ogata K (2020) Tracking intermediate performance of vigilant attention using multiple eye metrics. Sleep 43(3). Doi:10.1093/sleep/zsz219

2

Bjorness TE, Greene RW (2020) Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an orexin Receptor-Modulated Manner. Eneuro 7(6). Doi:10.1523/ENEURO.0283-20.2020

3

Bjorness TE, Kulkarni A, Rybalchenko V, Suzuki A, Bridges C, Harrington AJ, Cowan CW, Takahashi JS, Konopka G, Greene RW (2020) An essential role for MEF2C in the cortical response to loss of sleep in mice. eLife 9. doi:10.7554/eLife.58331

4

Chang YH, Katoh MC, Abdellatif AM, Xiafukaiti G, Elzeftawy A, Ojima M, Mizuno S, Kuno A, Takahashi S (2020) Uncovering the role of MAFB in glucagon production and secretion in pancreatic alpha-cells using a new alpha-cell-specific Mafb conditional knockout mouse model. Exp Anim Tokyo 69(2): 178-188. Doi:10.1538/expanim.19-0105

5

Choi D, Sato T, Ando T, Abe T, Akamatsu M, Kitazaki S (2020) Effects of cognitive and visual loads on driving performance after take-over request (TOR) in automated driving. Appl Ergon 85. Doi:10.1016/j.apergo.2020.103074

6

Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y (2020) Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. Internal Med 59(4): 577-579. Doi:10.2169/internalmedicine.2947-19

7

Deng ZB, Matsumoto Y, Kuno A, Ojima M, Xiafukaiti G, Takahashi S (2020) An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition. Int J Mol Sci 21(16). Doi:10.3390/ijms21165606

8

Disha SI, Furlani B, Drevensek G, Plut A, Yanagisawa M, Hudoklin S, Zitnik IP, Marc J, Drevensek M (2020) The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on-ETB knockout rats. Sci Rep 10(1). Doi:10.1038/s41598-020-71159-8

9

Enomoto M, Kitamura S, Tachimori H, Takeshima M, Mishima K (2020) Long-term use of hypnotics: Analysis of trends and risk factors. Gen Hosp Psychiat 62: 49-55. Doi:10.1016/j.genhosppsych.2019.11.008

10

Fujino M, Tagami A, Ojima M, Mizuno S, Abdellatif AM, Kuno A, Takahashi S (2020) c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells. Exp Anim Tokyo 69(2): 242-249. Doi:10.1538/expanim.19-0137

11

Fukuda K, Shibata Y, Sato H, Okabe S (2020) How the large-scale blackout following the 2018 Hokkaido Eastern Iburi earthquake impacted adolescents’ sleep patterns. Sleep Biol Rhythms 18(4): 351-354. Doi:10.1007/s41105-020-00278-6

12

Hashimoto M, Kumabe A, Kim JD, Murata K, Sekizar S, Williams A, Lu WZ, Ishida J, Nakagawa T, Endo M, Minami Y, Fukamizu A (2020) Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development. J Neurochem. Doi:10.1111/jnc.15149

13

Hirose Y, Kitazono T, Sezaki M, Abe M, Sakimura K, Funato H, Handa H, Vogt KE, Yanagisawa M (2020) Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway. P Natl Acad Sci USA 117(37): 23106-23112. Doi:10.1073/pnas.1917701117

14

Honda T, Takata Y, Cherasse Y, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M, Lazarus M, Oishi Y (2020) Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction. Iscience 23(6). Doi:10.1016/j.isci.2020.101240

15

Hori D, Sasahara S, Doki S, Oi Y, Matsuzaki I (2020) Prefrontal activation while listening to a letter of gratitude read aloud by a coworker face-to-face: A NIRS study. Plos One 15(9). Doi:10.1371/journal.pone.0238715

16

Hori D, Sasahara S, Oi Y, Doki S, Andrea CS, Takahashi T, Shiraki N, Ikeda T, Ikeda Y, Kambayashi T, Aoki E, Matsuzaki I (2020) Relationships between insomnia, long working hours, and long commuting time among public school teachers in Japan: a nationwide cross-sectional diary study. Sleep Med 75: 62-72. Doi:10.1016/j.sleep.2019.09.017

17

Ikeda T, Hori D, Ikeda Y, Takahashi T, Shiraki N, Andrea CS, Ohtaki Y, Doki S, Oi Y, Sasahara S, Saito T, Matsuzaki I (2020) School Ijime (Bullying) Experience Is a Possible Risk Factor for Current Psychological Distress among Science City Workers: A Cross-Sectional Study in Tsukuba, Japan. Tohoku J Exp Med 250(4): 223-231. Doi:10.1620/tjem.250.223

18

Imanishi A, Kawazoe T, Hamada Y, Kumagai T, Tsutsui K, Sakai N, Eto K, Noguchi A, Shimizu T, Takahashi T, Han G, Mishima K, Kanbayashi T, Kondo H (2020) Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat. Orphanet J Rare Dis 15(1). Doi:10.1186/s13023-020-01531-4

19

Jia DL, Bai PY, Wan NF, Liu J, Zhu Q, He YH, Chen GL, Wang J, Chen H, Wang C, Lyu AK, Lazarus M, Su YC, Urade Y, Yu Y, Zhang J, Shen YJ (2020) Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages. Circ Res 127(10): 1323-1336. Doi:10.1161/CIRCRESAHA.120.316784

20

Kaida K, Abe T, Iwaki S (2020) Counteracting effect of verbal ratings of sleepiness on dual task interference. Ind Health 58(5): 443-450. Doi:10.2486/indhealth.2020-0005

21

Kanai M, Jeon H, Ojima M, Nishino T, Usui T, Yadav MK, Kulathunga K, Morito N, Takahashi S, Hamada M (2020) Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation. Biochem Bioph Res Co 523(2): 452-457. Doi:10.1016/j.bbrc.2019.12.033

22

Kashiwagi M, Kanuka M, Tatsuzawa C, Suzuki H, Morita M, Tanaka K, Kawano T, Shin JW, Suzuki H, Itohara S, Yanagisawa M, Hayashi Y (2020) Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice. Curr Biol 30(6): 1002-1010. doi:10.1016/j.cub.2020.01.047

23

Kawasaki M, Kambe A, Yamamoto Y, Arulmozhiraja S, Ito S, Nakagawa Y, Tokiwa H, Nakano S, Shimano H (2020) Elucidation of Molecular Mechanism of a Selective PPAR alpha Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations. Int J Mol Sci 21(1). Doi:10.3390/ijms21010361

24

Kong DP, Wan QY, Li JJ, Zuo SK, Liu GZ, Liu Q, Wang CC, Bai PY, Duan SZ, Zhou B, Gounari F, Lyu AK, Lazarus M, Breyer RM, Yu Y (2020) DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation 141(8): 655-666. Doi:10.1161/CIRCULATIONAHA.119.042532

25

Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Cherasse Y, Naoi T, Wang SH, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M (2020) Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation. Neuron 107(3): 552-565. Doi:10.1016/j.neuron.2020.05.008

26

Kutsumura N, Koyama Y, Saitoh T, Yamamoto N, Nagumo Y, Miyata Y, Hokari R, Ishiyama A, Iwatsuki M, Otoguro K, Omura S, Nagase H (2020) Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities. Molecules 25(5). Doi:10.3390/molecules25051112

27

Li R, Wang YQ, Liu WY, Zhang MQ, Li L, Cherasse Y, Schiffmann SN, d’Exaerde AD, Lazarus M, Qu WM, Huang ZL (2020) Activation of adenosine A(2A) receptors in the olfactory tubercle promotes sleep in rodents. Neuropharmacology 168. Doi:10.1016/j.neuropharm.2019.107923

28

Li YD, Bao HC, Luo YJ, Yoan C, Sullivan HA, Quintanilla L, Wickersham I, Lazarus M, Shin YYI, Song J (2020) Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. eLlife 9. Doi:10.7554/eLife.53129

29

Li YD, Ge J, Luo YJ, Xu W, Wang J, Lazarus M, Hong ZY, Qu WM, Huang ZL (2020) High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. Pain 161(2): 288-299. Doi:10.1097/j.pain.0000000000001725

30

Li YD, Luo YJ, Xu W, Ge J, Cherasse Y, Wang YQ, Lazarus M, Qu WM, Huang ZL (2020) Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Mol Psychiatr. Doi:10.1038/s41380-020-00906-0

31

Lou TT, Ma J, Wang ZQ, Terakoshi Y, Lee CY, Asher G, Cao LQ, Chen ZY, Sakurai K, Liu QH (2020) Hyper-Activation of mPFC Underlies Specific Traumatic Stress-Induced Sleep-Wake EEG Disturbances. Front Neurosci 14. Doi:10.3389/fnins.2020.00883

32

Maezono SEB, Kanuka M, Tatsuzawa C, Morita M, Kawano T, Kashiwagi M, Nondhalee P, Sakaguchi M, Saito T, Saido TC, Hayashi Y (2020) Progressive Changes in Sleep and Its Relations to Amyloid-beta Distribution and Learning in Single App Knock-In Mice. eNeuro 7(2). Doi:10.1523/ENEURO.0093-20.2020

33

Matsumoto S, Ohyama K, Diaz J, Yanagisawa M, Greene RW, Vogt KE (2020) Enhanced cortical responsiveness during natural sleep in freely behaving mice. Sci Rep 10(1). Doi:10.1038/s41598-020-59151-8

34

Matsuura Y, Ishikawa Y, Murayama Y, Yokoyama T, Somerville RA, Kitamoto T, Mohri S (2020) Eliminating transmissibility of bovine spongiform encephalopathy by dry-heat treatment. J Gen Virol 101(1): 136-142. Doi:10.1099/jgv.0.001335

35

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H (2020) Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. Hepatology 71(5): 1609-1625. Doi:10.1002/hep.30953

36

Miidera H, Enomoto M, Kitamura S, Tachimori H, Mishima K (2020) Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan. Diabetes Care 43(4): 885-893. Doi:10.2337/dc19-1175

37

Miyazaki S, Leproux P, Couderc V, Hayashi Y, Kano H (2020) Multimodal nonlinear optical imaging ofCaenorhabditis eleganswith multiplex coherent anti-Stokes Raman scattering, third-harmonic generation, second-harmonic generation, and two-photon excitation fluorescence. App Phys Express 13(7). Doi:10.35848/1882-0786/ab9711

38

Miyazaki T, Kanda T, Tsujino N, Ishii R, Nakatsuka D, Kizuka M, Kasagi Y, Hino H, Yanagisawa M (2020) Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process. Cereb Cortex 30(7): 3977-3990. Doi:10.1093/cercor/bhaa012

39

Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, Okita N, Sudo Y, Nakagawa Y, Shimano H, Higami Y (2020) Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci Rep 10(1). Doi:10.1038/s41598-020-57428-6

40

Morita E, Yanagisawa M, Ishihara A, Matsumoto S, Suzuki C, Ikeda Y, Ishitsuka M, Hori D, Doki S, Oi Y, Sasahara S, Matsuzaki I, Satoh M (2020) Association of wood use in bedrooms with comfort and sleep among workers in Japan: a cross-sectional analysis of the SLeep Epidemiology Project at the University of Tsukuba (SLEPT) study. J Wood Sci 66(1). Doi:10.1186/s10086-020-1852-y

41

Nagaura Y, Kondo H, Nagayoshi M, Maeda T (2020) Sarcopenia is associated with insomnia in Japanese older adults: a cross-sectional study of data from the Nagasaki Islands study. BMC Geriatrics 20(1). Doi:10.1186/s12877-020-01658-w

42

Nagumo Y, Katoh K, Iio K, Saitoh T, Kutsumura N, Yamamoto N, Ishikawa Y, Irukayama-Tomobe Y, Ogawa Y, Baba T, Tanimura R, Yanagisawa M, Nagase H (2020) Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine. Bioorg Med Chem Lett 30(17). Doi:10.1016/j.bmcl.2020.127360

43

Nagumo Y, Ueta Y, Nakayama H, Osaki H, Takeuchi Y, Uesaka N, Kano M, Miyata M (2020) Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations. Cell Rep 31(12). Doi:10.1016/j.celrep.2020.107797

44

Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y (2020) Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2 beta. Genetics 216(3): 753-764. Doi:10.1534/genetics.120.303435

45

Natori Y, Sasaki E, Soeda S, Furukawa S, Azami Y, Tokuda E, Kanbayashi T, Saji S (2020) Risk of immunotherapy-related narcolepsy in genetically predisposed patients: a case report of narcolepsy after administration of pembrolizumab. J Immunother Cancer 8(2). Doi:10.1136/jitc-2020-001164

46

Noguchi K, Ishida J, Kim JD, Muromachi N, Kako K, Mizukami H, Lu WZ, Ishimaru T, Kawasaki S, Kaneko S, Usui J, Ohtsu H, Yamagata K, Fukamizu A (2020) Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming. P Natl Acad Sci USA 117(6): 3150-3156. Doi:10.1073/pnas.1909124117

47

Ogata H, Horie M, Kayaba M, Tanaka Y, Ando A, Park I, Zhang SM, Yajima K, Shoda J, Omi N, Kaneko M, Kiyono K, Satoh M, Tokuyama K (2020) Skipping Breakfast for 6 Days Delayed the Circadian Rhythm of the Body Temperature without Altering Clock Gene Expression in Human Leukocytes. Nutrients 12(9). Doi:10.3390/nu12092797

48

Ogawa Y, Miyoshi C, Obana N, Yajima K, Hotta-Hirashima N, Ikkyu A, Kanno S, Soga T, Fukuda S, Yanagisawa M (2020) Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice. Sci Rep 10(1). Doi:10.1038/s41598-020-76562-9

49

Ohyama K, Kanda T, Miyazaki T, Tsujino N, Ishii R, Ishikawa Y, Muramoto H, Grenier F, Makino Y, McHugh TJ, Yanagisawa M, Greene RW, Vogt KE (2020) Structure of cortical network activity across natural wake and sleep states in mice. Plos One 15(5). Doi:10.1371/journal.pone.0233561

50

Okabe S, Hayashi M, Abe T, Fukuda K (2020) Presentation of familiar odor induces negative dream emotions during rapid eye movement (REM) sleep in healthy adolescents. Sleep Med 66: 227-232. Doi:10.1016/j.sleep.2019.11.1260

51

Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M (2020) Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16(high) Cells In Vivo. Cell Metab 32(5): 814-828. Doi:10.1016/j.cmet.2020.09.006

52

Omoya R, Miyajima M, Ohta K, Suzuki Y, Aoki A, Fujiwara M, Watanabe T, Yoshida N, Suwa H, Kawara T, Takahashi H, Matsushima E, Takeuchi T (2021) Heart rate response to orthostatic challenge in patients with dementia withLewy bodies andAlzheimer’s disease. Psychogeriatrics 21(1): 62-70. Doi:10.1111/psyg.12625

53

Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H (2020) Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. Sci Rep 10(1). Doi:10.1038/s41598-020-65647-0

54

Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Yanagisawa M, Nagase H (2020) Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. Bioorg Med Chem Lett 30(3). Doi:10.1016/j.bmcl.2019.126893

55

Sasahara S, Andrea CS, Suzuki G, Oi Y, Doki S, Hori D, Ohira T, Matsuda C, Inoue N, Takahashi T, Ohtaki Y, Saito T, Furukawa S, Ogata K, Matsuzaki I (2020) Effect of exercise on brain function as assessed by functional near-infrared spectroscopy during a verbal fluency test in a simulated International Space Station environment: A single-case, experimental ABA study in Japan. Acta Astronauti 166: 238-242.Doi:10.1016/j.actaastro.2019.10.013

56

Satoh A, Han S, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H (2020) CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. Iscience 23(3). Doi:10.1016/j.isci.2020.100930

57

Shimizu S, Takenoshita N, Inagawa Y, Tsugawa A, Hirose D, Kaneko Y, Ogawa Y, Serisawa S, Sakurai S, Hirao K, Kanetaka H, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H (2020) Positive Association Between Cognitive Function and Cerebrospinal Fluid Orexin A Levels in Alzheimer’s Disease. J Alzheimers Dis 73(1): 117-123. Doi:10.3233/JAD-190958

58

Shimizu Y, Tamura T, Kemmochi A, Owada Y, Ozawa Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Oda T, Ohkohchi N (0) Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model. J Gastroen Hepatol. Doi:10.1111/jgh.15239

59

Suzuki A, Yanagisawa M, Greene RW (2020) Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice. P Natl Acad Sci USA 117(19): 10547-10553. Doi:10.1073/pnas.1906840117

60

Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R (2020) alpha-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model. Brain 143: 249-265. Doi:10.1093/brain/awz380

61

Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T (2020) A discrete neuronal circuit induces a hibernation-like state in rodents. Nature 583(7814): 109-114. Doi:10.1038/s41586-020-2163-6

62

Tanaka Y, Ogata H, Kayaba M, Ando A, Park I, Yajima K, Araki A, Suzuki C, Osumi H, Zhang SM, Ishihara A, Takahashi K, Shoda J, Nabekura Y, Satoh M, Tokuyama K (2020) Effect of a single bout of exercise on clock gene expression in human leukocyte. J Appl Physiol 128(4): 847-854. Doi:10.1152/japplphysiol.00891.2019

63

Tsai CJ, Liu CY, Lazarus M, Hayashi Y (2020) Sleep architecture of adenosine A(2A) receptor-deficient mice. Sleep Biol Rhythms 18(3): 275-279. Doi:10.1007/s41105-020-00260-2

64

Tsuneoka Y, Funato H (2020) Modified in situ Hybridization Chain Reaction Using Short Hairpin DNAs. Front Mol Neurosci 13. Doi:10.3389/fnmol.2020.00075

65

Umeno S, Kato C, Nagaura Y, Kondo H, Eto H (2020) Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications. BMC Preg Childbirth 20(1). Doi:10.1186/s12884-020-02868-1

66

Urashima K, Ichinose K, Kondo H, Maeda T, Kawakami A, Ozawa H (2020) The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study. Plos One 15(3). Doi:10.1371/journal.pone.0230273

67

Usui T, Morito N, Shawki HH, Sato Y, Tsukaguchi H, Hamada M, Jeon H, Yadav MK, Kuno A, Tsunakawa Y, Okada R, Ojima T, Kanai M, Asano K, Imamura Y, Koshida R, Yoh K, Usui J, Yokoi H, Kasahara M, Yoshimura A, Muratani M, Kudo T, Oishi H, Yamagata K, Takahashi S (2020) Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis. Kidney Int 98(2): 391-403. Doi:10.1016/j.kint.2020.02.038

68

Yadav MK, Inoue Y, Nakane-Otani A, Tsunakawa Y, Jeon H, Samir O, Teramoto A, Kulathunga K, Kusakabe M, Nakamura M, Kudo T, Takahashi S, Hamada M (2020) Transcription factor MafB is a marker of tumor-associated macrophages in both mouse and humans. Biochem Bioph Res Co 521(3): 590-595. Doi:10.1016/j.bbrc.2019.10.125

69

Yoshida S, Kawahara Y, Sasatani T, Kiyono K, Kobayashi Y, Funato H (2020) Infants Show Physiological Responses Specific to Parental Hugs. Iscience 23(4). Doi:10.1016/j.isci.2020.100996

70

Zavjalov E, Zaboronok A, Kanygin V, Kasatova A, Kichigin A, Mukhamadiyarov R, Razumov I, Sycheva T, Mathis BJ, Maezono SEB, Matsumura A, Taskaev S (2020) Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice. Int J Radiat Biol 96(7): 868-878. Doi:10.1080/09553002.2020.1761039

71

Zhang SM, Osumi H, Uchizawa A, Hamada H, Park I, Suzuki Y, Tanaka Y, Ishihara A, Yajima K, Seol J, Satoh M, Omi N, Tokuyama K (2020) Changes in sleeping energy metabolism and thermoregulation during menstrual cycle. Physiol Rep 8(2). Doi:10.14814/phy2.14353

72

Zhang SM, Takano J, Murayama N, Tominaga M, Abe T, Park I, Seol J, Ishihara A, Tanaka Y, Yajima K, Suzuki Y, Suzuki C, Fukusumi S, Yanagisawa M, Kokubo T, Tokuyama K (2020) Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial. Nutrients 12(12). Doi:10.3390/nu12123671

73

Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K (2020) Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Addict Biol 25(1). doi:10.1111/adb.12723

2019

    

2019 Full list of publication

1

Chang YH, Nishimura S, Oishi H, Kelly VP, Kuno A, Takahashi S (2019) TRMT2A is a novel cell cycle regulator that suppresses cell proliferation. Biochem Biophys Res Commun 508(2): 410-415. doi:10.1016/j.bbrc.2018.11.104

2

Fujii S, Kaushik MK, Zhou XZ, Korkutata M, Lazarus M (2019) Acute social defeat stress increases sleep in mice. Front Neurosci 13. doi:10.3389/fnins.2019.00322

3

Fujimori K, Aritake K, Oishi Y, Nagata N, Maehara T, Lazarus M, Urade Y (2019) L-PGDS-produced PGD(2) in premature, but not in mature, adipocytes increases obesity and insulin resistance. Sci Rep 9. doi:10.1038/s41598-018-38453-y

4

Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, et al. (2019) A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain. Dis Model Mech 12(9). doi:10.1242/dmm.038828

5

Hada K, Hirota K, Inanobe A, Kako K, Miyata M, Araoi S, Matsumoto M, Ohta R, et al. (2019) Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans. J Biol Chem 294(9): 3091-3099. doi:10.1074/jbc.RA118.004726

6

Hori D, Oi Y, Ohtaki Y, Andrea CS, Takahashi T, Shiraki N, Ikeda T, Ikeda Y, et al. (2019) Association between flourishing mental health and occupational stress among workers of Tsukuba Science City, Japan: a cross-sectional study. Environ Health Prev 24(1). doi:10.1186/s12199-019-0823-7

7

Hori D, Takao S, Kawachi I, Ohtaki Y, Andrea CS, Takahashi T, Shiraki N, Ikeda T, et al. (2019) Relationship between workplace social capital and suicidal ideation in the past year among employees in Japan: a cross-sectional study. BMC Public Health 19. doi:10.1186/s12889-019-7244-9

8

Imanishi A, Kanbayashi T, Sagawa Y, Taniguchi T, Usumoto A, Yuge K, Kotorii N, Kinoshita T, et al. (2019) Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination. Sleep Biol Rhythms 17(2): 259-261. doi:10.1007/s41105-019-00210-7

9

Kakizaki M, Tsuneoka Y, Takase K, Kim SJ, Choi J, Ikkyu A, Abe M, Sakimura K, Yanagisawa M, Funato H (2019) Differential roles of each orexin receptor signaling in obesity. iScience 20: 1-13. doi:10.1016/j.isci.2019.09.003

10

Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, et al. (2019) Clec10a regulates mite-induced dermatitis. Sci Immunol 4(42). doi:10.1126/sciimmunol.aax6908

11

Kawai H, Takaki M, Sakamoto S, Shibata T, Tsuchida A, Yoshimura B, Yada Y, Matsumoto N, et al. (2019) Anti-NMDA-receptor antibody in initial diagnosis of mood disorder. Eur Neuropsychopharmacol 29(9): 1041-1050. doi:10.1016/j.euroneuro.2019.07.137

12

Kitamura S, Takahashi M, Mishima K (2019) Sleep problem but not chronotype is associated with retirement from shift work: a cross-sectional retrospective study. Sleep Biol Rhythms 17(3): 331-337. doi:10.1007/s41105-019-00221-4

13

Kodani S, Soya S, Sakurai T (2019) Optogenetic manipulation of neural circuits during monitoring sleep/wakefulness states in mice. J Vis Exp (148). doi:10.3791/58613

14

Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin RJ, Murakoshi N, Fujii S, et al. (2019) Enhancing endogenous adenosine A(2A) receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function. Neuropharmacology 144: 122-132. doi:10.1016/j.neuropharm.2018.10.022

15

Kutsumura N, Inagaki M, Kiriseko A, Saito T (2019) Total synthesis of 3-epi-Juruenolide C. Chem Pharm Bull 67(6): 594-598. doi:10.1248/cpb.c19-00209

16

Kutsumura N, Numata K, Mosaki S, Saito T (2019) Total synthesis of haplacutines B and C. Heterocycles 99(1): 614-624. doi:10.3987/COM-18-S(F)7

17

Lu WZ, Kim JD, Tabara S, Kwon C, Mizukami H, Kimura K, Fukamizu A (2019) The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation. Biochem Biophys Res Commun 514(4): 1185-1191. doi:10.1016/j.bbrc.2019.05.077

18

Matsubara T, Suzuki K, Kawasaki A, Miyamoto M, Okamura M, Kanbayashi T, Takekawa H, Nakamura T, et al. (2019) Sudden onset of sleep caused by hypothalamic infarction: a case report. BMC Neurol 19(1). doi:10.1186/s12883-019-1414-3

19

Miyagawa T, Hida A, Shimada M, Uehara C, Nishino Y, Kadotani H, Uchiyama M, Ebisawa T, et al. (2019) A missense variant in PER2 is associated with delayed sleep-wake phase disorder in a Japanese population. J Hum Genet 64(12): 1219-1225. doi:10.1038/s10038-019-0665-6

20

Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, et al. (2019) Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice. Proc Natl Acad Sci U.S.A. 116(32): 16062-16067. doi:10.1073/pnas.1906774116

21

Mizukami H, Kim JD, Tabara S, Lu WZ, Kwon C, Nakashima M, Fukamizu A (2019) KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts. J Biochem 165(4): 335-342. doi:10.1093/jb/mvy106

22

Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M, Wakai K (2019) Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study. Nagoya J Med Sci 81(3): 489-500. doi:10.18999/nagjms.81.3.489

23

Nagano K, Kwon C, Ishida J, Hashimoto T, Kim JD, Kishikawa N, Murao M, Kimura K, et al. (2019) Cooperative action of APJ and alpha 1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5): 383-392. doi:10.1093/jb/mvz071

24

Nakahara K, Naba K, Saitoh T, Sugai T, Obata R, Nishiyama S, Einaga Y, Yamamoto T (2019) Electrochemical pinacol coupling of acetophenone using boron-doped diamond electrode. ChemElectroChem 6(16): 4153-4157. doi:10.1002/celc.201900202

25

Ogata H, Kayaba M, Tanaka Y, Yajima K, Iwayama K, Ando A, Park I, Kiyono K, et al. (2019) Effect of skipping breakfast for 6 days on energy metabolism and diurnal rhythm of blood glucose in young healthy Japanese males. Am J Clin Nutr 110(1): 41-52. doi:10.1093/ajcn/nqy346

26

Ohtaki Y, Doki S, Kaneko H, Hirai Y, Oi Y, Sasahara S, Matsuzaki I (2019) Relationship between suicidal ideation and family problems among young callers to the Japanese crisis hotline. PLoS One 14(7). doi:10.1371/journal.pone.0220493

27

Ono H, Kanbayashi T, Imanishi A, Ayabe T, Sagawa Y, Tsutsui K, Ohmori Y, Takeshima M, Nishino S, Shimizu T (2019) Clinical characteristics of symptomatic narcolepsy or hypersomnia: an analysis of 182 consecutive cases with neurological disorders associated with hypersomnolence. Sleep Biol Rhythms 17(1): 123-140. doi:10.1007/s41105-018-0186-2

28

Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, et al. (2019) Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Bioorg Med Chem Lett 29(18): 2655-2658. doi:10.1016/j.bmcl.2019.07.039

29

Schutz B, Ruppert AL, Strobel O, Lazarus M, Urade Y, Buchler MW, Weihe E (2019) Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract. Sci Rep 9. doi:10.1038/s41598-019-53997-3

30

Seol J, Fujii Y, Park I, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Okura T, et al. (2019) Distinct effects of orexin receptor antagonist and GABA(A) agonist on sleep and physical/cognitive functions after forced awakening. Proc Natl Acad Sci U.S.A. 116(48): 24353-24358. doi:10.1073/pnas.1907354116

31

Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang YN, Motomura K, Shimura T, et al. (2019) Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism. Sci Rep 9. doi:10.1038/s41598-019-41631-1

32

Srinivasan S, Hosokawa T, Vergara P, Cherasse Y, Naoi T, Sakurai T, Sakaguchi M (2019) Miniaturized microscope with flexible light source input for neuronal imaging and manipulation in freely behaving animals. Biochem Biophys Res Commun 517(3): 520-524. doi:10.1016/j.bbrc.2019.07.082

33

Sugiyama A, Yamada M, Furuie H, Gotoh L, Saitoh A, Nagase H, Oka JI, Yamada M (2019) Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats. J Pharmacol Sci 139(3): 174-179. doi:10.1016/j.jphs.2019.01.002

34

Takahashi T, Hori D, Ikeda T, Ikeda Y, Shiraki N, Andrea CS, Ohtaki Y, Doki S, et al. (2019) Non-Regular Employment Status Is Associated with Psychological Distress among Young Researchers: A Cross-Sectional Study in Tsukuba, Japan. Tohoku J Exp Med 249(1): 57-64. doi:10.1620/tjem.249.57

35

Tanimura J, Nakagawa H, Tanake T, Kikuchi A, Osada S, Tanaka Y, Tokuyama K, Takamura T (2019) The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia. Endocr J 66(7): 615-620. doi:10.1507/endocrj.EJ18-0542

36

Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui T, Kanai M, et al. (2019) Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients. Exp Anim 68(1): 103-111. doi:10.1538/expanim.18-0093

37

Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M (2019) Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells. PLoS One 14(1). doi:10.1371/journal.pone.0210060

38

Watanabe T, Miyajima M, Ohta K, Yoshida N, Omoya R, Fujiwara M, Suzuki Y, Murata I, et al. (2019) Predicting postictal suppression in electroconvulsive therapy using analysis of heart rate variability. J Affect Disord 246: 355-360. doi:10.1016/j.jad.2018.12.090

39

Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, Oishi H, Takahashi S (2019) MafB is important for pancreatic β-cell maintenance under a MafA deficient condition. Mol Cell Biol 39(17). doi:10.1128/MCB.00080-19

40

Yamabe M, Horie K, Shiokawa H, Funato H, Yanagisawa M, Kitagawa H (2019) MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks. Sci Rep 9. doi:10.1038/s41598-019-51269-8

41

Yamada D, Yanagisawa S, Yoshizawa K, Yanagita S, Oka JI, Nagase H, Saitoh A (2019) Selective agonists of the delta-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice. Neuropharmacology 160. doi:10.1016/j.neuropharm.2019.107792

42

Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, et al. (2019) Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring. Bioorg Med Chem 27(8): 1747-1758. doi:10.1016/j.bmc.2019.03.010

43

Yasugaki S, Liu CY, Kashiwagi M, Kanuka M, Honda T, Miyata S, Yanagisawa M, Hayashi Y (2019) Effects of 3 weeks of water immersion and restraint stress on sleep in mice. Front Neurosci 13. doi:10.3389/fnins.2019.01072

44

Yata M, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y, Yanagisawa M, Nagase H (2019) A novel rearrangement reaction of morphinan to arylmorphan skeletons and the pharmacologies of arylmorphan derivatives. Heterocycles 99(1): 134-144. doi:10.3987/COM-18-S(F)53

45

Zhang Y, Sugai T, Yamamoto T, Yamamoto N, Kutsumura N, Einaga Y, Nishiyama S, Saitoh T, Nagase H (2019) Oxidative cleavage of the acyl-carbon bond in ohenylacetone with electrogenerated superoxide anions. ChemElectroChem 6(16): 4194-4198. doi:10.1002/celc.201801308

46

Zhang Z, Liu WY, Diao YP, Xu W, Zhong YH, Zhang JY, Lazarus M, Liu YY, Qu WM, Huang AL (2019) Superior colliculus GABAergic neurons are essential for acute dark induction of wakefulness in mice. Curr Biol 29(4): 637-644. doi:10.1016/j.cub.2018.12.031

47

Zhou XZ, Oishi Y, Cherasse Y, Korkutata M, Fujii S, Lee CY, Lazarus M (2019) Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice. Neurochem Int 124: 256-263. doi:10.1016/j.neuint.2019.01.020

2018

    

2018 Full List of Publications

1

Nakamura Y, Matsuzaka, T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A (2018) Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation. Cell Death & Disease 9:1181. doi:10.1038/s41419-018-1226-1

2

Bjorness TE, Greene RW (2018) Sleep deprivation alters the time course but not magnitude of locomotor sensitization to cocaine. Sci Rep. 8:17672. doi:10.1038/s41598-018-36002-1

3

Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Mishima K, Honda M, Tokunaga K et al. (2018) A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia. J. Hum. Genet. 63(12):1259-1267 doi:10.1038/s10038-018-0518-8

4

Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, Sakurai T (2018) Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture. Front Neurosci. 12:892 doi:10.3389/fnins.2018.00892

5

Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M (2018) Sleep and Wakefulness Are Controlled by Ventral Medial Midbrain/Pons GABAergic Neurons in Mice. J Neurosci. 38(47):10080-10092. doi:10.1523/JNEUROSCI.0598-18.2018

6

Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa H, Takahashi S, Ema M (2018) Klf5 suppresses ERK signaling in mouse pluripotent stem cells. PLoS One 13(11):e0207321 doi:10.1371/journal.pone.0207321

7

Saitoh A, Soda A, Kayashima S, Yoshizawa K, Oka JI, Nagase H, Yamada M (2018) A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice. J Pharmacol Sci. 138(3):176-183. doi:10.1016/j.jphs.2018.09.009

8

Kaushik MK, AritakeK, Cherasse Y, Sharma R, Urade Y (2018) A gain-of-function study of amelioration of pentylenetetrazole-induced seizures by endogenous prostaglandin D-2 Neurosci Lett. 686:140-144. doi:10.1016/j.neulet.2018.09.011

9

Kutsumura N, Nagase H (2018) Unique Reactions of Morphinan Skeletons and Conversions of the Skeletons to Active Alkaloids. J Syn Org Chem Jpn. [Japanese: 有機合成化学協会誌] 76(9):914-921. doi:10.5059/yukigoseikyokaishi.76.914

10

Kutsumura N, Okada T, Imaide S, Fujii H, Nagase H (2018) Acetic Anhydride Mediated Retro-Ene Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage. Synthesis-Stuttgart 50(21):4263-4269. 10.1055/s-0036-1589138

11

Zhang Y, Sugai T, Yamamoto T, Yamamoto, N, Kutsumura N, Nishiyama S, Einaga Y, Saitoh, T, Nagase H (2018) Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions. ChemElectroChem. 5. 10.1002/celc.201801308.

12

Kuwano N, Kato, TA, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S (2018) Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study. J Affect Disorders. 240:88-98. doi:10.1016/j.jad.2018.07.040

13

Murata K, Lu WZ, Hashimoto M, Ono N, Muratani M, Nishikata K, Kim JD, Ebihara S, Ishida J, Fukamizu A (2018) PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products. iScience. 8:200-+. doi:10.1016/j.isci.2018.09.023

14

Sakikubo M, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, Goto T, Hirata K, Masui T, Dor Y, Fujiyama T, Hoshino M, Uemoto S, Kawaguchi Y (2018) Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway. Sci Rep. 8:15812. doi:10.1038/s41598-018-34093-4

15

Cherasse Y, Aritake K, Oishi Y, Kaushik MK, Korkutata M, Urade Y (2018) The Leptomeninges Produce Prostaglandin D-2 Involved in Sleep Regulation in Mice. Front Cell Neurosci. 12:357. doi:10.3389/fncel.2018.00357

16

Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M (2018) A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice Proc Natl Acad Sci USA. 115(41):10458-10463. doi:10.1073/pnas.1810823115

17

Sugiyama A, Yamada M, Saitoh A, Nagase H, Oka JI, Yamada M (2018) Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats. Psychopharmacology. 235(10):2947-2955. doi:10.1007/s00213-018-4984-7

18

Kulathunga K, Hamada M, Hiraishi Y, Otake M, Tran MTN, Cheng O, Tanaka J, Sakasai T, Sakaguchi S, Sugiyama Y, Fleischmann BK, Takahashi S, Miwa Y (2018) A Novel iRFP-Incorporated in vivo Murine Atherosclerosis Imaging System. Sci Rep. 8:14515. doi: 10.1038/s41598-018-32456-5

19

Kutsumura N, Kiriseko A, Niwa K, Saito T (2018) Total Syntheses of 3-epi-Litsenolide D-2 and Lincomolide A. J Org Chem. 83(18):11450-11457. doi:10.1021/acs.joc.8b01825

20

Mochizuki A, Nakayama K, Nakamura S, Dantsuji M, Kamijo R, Shioda S, Sakurai T, Ozeki M, Inoue T (2018) Involvement of orexin in lipid accumulation in the liver. J Oral Sci. 60(3):76-82. doi:10.1016/j.job.2018.07.001

21

Takaya D, Inaka K, Omura, A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A (2018) Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies. Bioorgan Med Chem. 26(16):4726-4734. doi:10.1016/j.bmc.2018.08.014

22

Niwa Y, Kanda GN, Yamada RG, Shi S, Sunagawa GA, Ukai-Tadenuma M, Fujishima H, Matsumoto N, Masumoto K, Nagano M, Kasukawa T, Galloway J, Perrin D, Shigeyoshi Y, Ukai H, Kiyonari H, Sumiyama K, Ueda HR (2018) Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep. Cell Reports. 24(9):2231. doi:10.1016/j.celrep.2018.07.082

23

Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M (2018) Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response. Front Neurosci. 12:535. doi:10.3389/fnins.2018.00535

24

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawas A, Narumiya S, Furuyashiki T (2018) Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. 23(8):1717-1730. doi:10.1038/mp.2017.177

25

Sato Y, Tsukaguchi H, Takahashi S, Yoshimura A et al. (2018) A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. Kidney Int. 94(2):396-407. doi:10.1016/j.kint.2018.02.025

26

Yoshida S, Ohnishi R, Tsuneoka Y, Yamamoto-Mimura Y, Muramatsu R, Kato T, Funato H, Kuroda KO (2018) Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups. Front Cell Neurosci. 12:204. doi:10.3389/fncel.2018.00204

27

Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T (2018) Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons. J Neurosci. 38(28):6366-6378. doi:10.1523/JNEUROSCI.2835-17.2018

28

Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima Y, Yanagisawa M, Funato H, Hoshino M (2018) Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain. Cell Reports 24(1):79-94. doi:10.1016/j.celrep.2018.06.010

29

Araki M, Nakagawa Y, Oishi A, Han S, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H (2018) The Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha)Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 19(7):2148. doi:10.3390/ijms19072148

30

Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N, Shimano H (2018) Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes. Diabetes Res Clin Pract. 141:237-243. doi:10.1016/j.diabres.2018.05.019

31

Wang ZQ, Ma J, Miyoshi C, Lie YX, Sato M, Ogawa Y, Lou TT, Ma CY, Gao X, Lee C, Fujiyama T, Yang XJ, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao LQ, Takahashi S, Peng JM, Yu YH, Funato H, Yanagisawa M, Liu QH (2018) Quantitative phosphoproteomic analysis of the molecular substrates of sleep need. Nature. 558(7710):435-439. doi:10.1038/s41586-018-0218-8

32

Yajima K, Iwayama K, Ogata H, Park I, Tokuyama K (2018) Meal rich in rapeseed oil increases 24-h fat oxidation more than meal rich in palm oil. PLoS One. 13(6):e0198858. doi:10.1371/journal.pone.0198858

33

Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M (2018) Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy. Proc Natl Acad Sci USA. 23:6046-6051. doi:10.1073/pnas.1722686115

34

Schoonakker M, Meijer JH, Deboer T, Fifel K (2018) Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus. Sleep. 41(6): zsy051. doi:10.1093/sleep/zsy051

35

Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han S, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H (2018) Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Endocrinology. 159(6):2308-2323. doi:10.1210/en.2017-03179

36

Oda S, Tsuneoka Y, Yoshida S, Adachi-Akahane S, Ito M, Kuroda M, Funato H (2018) Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex. J Comp Neurol. 526(8):1329-1350. doi:10.1002/cne.24409

37

Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM (2018) Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control. J Neurosci. 38(22):5168-5181. doi:10.1523/JNEUROSCI.2955-17.2018

38

Honjoh S, Sasai S, Schiereck SS, Nagai H, Tononi G, Cirelli C (2018) Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus. Nat Commun. 9:2100. doi:10.1038/s41467-018-04497-x

39

Bjorness TE, Greene RW (2018) Dose response of acute cocaine on sleep/waking behavior in mice. Neurobiol Sleep Circadian Rhythms. 5:84-93. doi:10.1016/j.nbscr.2018.02.001

40

Wang YB, Cao LQ, Lee CY, Matsuo T, Wu KJ, Asher G, Tang LJ, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Cherasse Y, Zhou JM, Li YWB, Wang T, Zhan XW, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang ZQ, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu QH (2018) Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun. 9:2041. doi:10.1038/s41467-018-04324-3

41

Fifel K, Meijer JH, Deboer T (2018) Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures. Sci Rep. 8:7765. doi:10.1038/s41598-018-25770-5

42

Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T, Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H (2018) Molecular association model of PPAR alpha and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARM alpha. Biochem Biophys Res Commun. 499(2):239-245. doi:10.1016/j.bbrc.2018.03.135

43

Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, Kokubo T, Kurokawa T (2018) Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS One. 13(5):e0196422. doi:10.1371/journal.pone.0196422

44

Toyama S, Shimoyama N, Tagaito Y, Nagase H, Saitoh T, Yanagisawa M, Shimoyama M (2018) Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats. Anesthesiology. 128(5):992-1003. doi:10.1097/ALN0000000000002161

45

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B (2018) Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology. 133:395-403. doi:10.1016/j.neuropharm.2018.02.010

46

Luo YJ, Li YD, Wang L, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, Huang ZL (2018) Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D-1 receptors. Nat Commun. 9:1576. doi:10.1038/s41467-018-03889-3

47

Yang SR, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DR, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL (2018) The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLOS Biol. 16(4): e2002909. doi:10.1371/journal.pbio.2002909

48

Katoh MC, Jung YS, Ugboma CM, Shimbo M, Kuno A, Basha WA, Kudo T, Oishi H, Takahashi S (2018) MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic alpha Cells In Vivo. Mol Cell Biol. 38(8): e00504-17. doi:10.1128/MCB.00504-17

49

Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H (2018) Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. Pharmacol Rep. 70(2):350-354. doi:10.1016/j.pharep.2017.08.018

50

Monma T, Ando A, Asanuma T, Yoshitake Y, Yoshida G, Miyazawa T, Ebine N, Takeda S, Omi N, Satoh M, Tokuyama K, Takeda F (2018) Sleep disorder risk factors among student athletes. Sleep Med. 44(76):76-81. doi:10.1016/j.sleep.2017.11.1130

51

Yamamoto T, Akahori M, Natsui K, Saitoh T, Einaga Y (2018) Controlled decoration of boron-doped diamond electrodes by electrochemical click reaction (e-CLICK). Carbon. 130:350-354. doi:10.1016/j.carbon.2017.12.098

52

Kitada N, Saitoh T, Ikeda Y, Iwano S, Obata R, Niwa H, Hirano T, Miyawaki A, Suzuki K, Nishiyama S, Maki SA (2018) Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution. Tetrahedron Lett. 59(12)1087-1090. doi:10.1016/j.tetlet.2018.01.078

53

Yamamoto T, Riehl B, Naba, K, Nakahara K, Wiebe A, Saitoh T, Waldvogel SR, Einaga Y (2018) A solvent-directed stereoselective and electrocatalytic synthesis of diisoeugenol. Chem Commun 54(22):2771-2773. doi:10.1039/c8cc00794b

54

Kutsumura N, Koyama Y, Suzuki Y, Tominaga K, Yarnarnoto N, Saitoh T, Nagumo Y, Nagase H (2018) Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton. Org Lett. 20(6):1559-1562. doi:10.1021/acs.orglett.8b00288

55

Kaida K, Abe T (2018) Attentional lapses are reduced by repeated stimuli having own-name during a monotonous task. PLoS One. 13(3): e0194065. doi:10.1371/journal.pone.0194065

56

Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H, Yanagisawa M (2018) Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice. Sleep. 41(3): zsx209. doi:10.1093/sleep/zsx209

57

Fox BM, Becker BK, Loria AS, Hyndman KA, Jin CH, Clark H, Johns R, Yanagisawa M, Pollock DM, Pollock JS (2018) Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1. J Am Heart Assoc. 7(4): e007863. doi:10.1161/JAHA.117.007863

58

Ikeda Y, Saitoh T, Niwa K, Nakajima T, Kitada N, Maki SA, Sato M, Citterio D, Nishiyama S, Suzuki K (2018) An allylated firefly luciferin analogue with luciferase specific response in living cells. Chem Commun. 54(14):1774-1777. doi:10.1039/c7cc09720d

59

Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2018) Essential structure of orexin 1 receptor antagonist YNT-707, Part II:Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity. Bioorg Med Chem Lett. 28(4):774-777. doi:10.1016/j.bmcl.2017.12.069

60

Yuan XM, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y (2018) Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Nat Commun. 9:636. doi:10.1038/s41467-018-03038-w

61

Garcia SV, Brischoux F, Clement O, Libourel PA, Arthaud S, Lazarus M, Luppi PH, Fort P (2018) Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. Nat Commun. 9:504. doi:10.1038/s41467-017-02761-0

62

Jung YS, Zhou, RY, Kato T, Usui, JK, Muratani, M, Oishi H, Heck MMS, Takahashi S (2018) Isl1 beta Overexpression With Key beta Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion. Endocrinology. 159(2):869-882. doi:10.1210/en.2017-00663

63

Tateno K, Ogawa R, Sakamoto R, Tsuchiya M, Kutsumura N, Otani T, Ono K, Kawai H, Saito T (2018) Dibenzopyrrolo[1,2-a][1,8]naphthyridines: Synthesis and Structural Modification of Fluorescent L-Shaped Heteroarenes. J Org Chem. 83(2):690-702. doi:10.1021/acs.joc.7b02674

64

Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M (2018) The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice. Behav Brain Res. 336:77-84. doi:10.1016/j.bbr.2017.08.041

65

Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M, Nishino S, Shimizu T (2018) Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation. Neuropsych Dis Treat. 14:1281-1286. doi:10.2147/NDT.S158865

66

Liguori G, Tafuri S, Miyoshi C, Yanagisawa M, Squillacioti C, De Pasquale V, Mirabella N, Vittoria A, Costagliola A (2018) Localization of orexin B and orexin-2 receptor in the rat epididymis. ACTA Histochem. 120(3):292-297. doi:10.1016/j.acthis.2018.02.011

67

Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K, Uemura S, Shimizu T (2018) Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness. Neuropsych Dis Treat. 14:451-457. doi:10.2147/NDT.S158651

68

Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S (2018) Transcription factor MafB may play an important role in secondary hyperparathyroidism. Kidney Int. 93(1):54-68. doi:10.1016/j.kint.2017.06.023

69

Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2018) Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant feature. Pathol Int. 68(1):12-22. doi:10.1111/pin.12612.

70

Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, Nagase H (2018) Synthesis of Novel 1,3-Dioxa-5-thiazatriquinane and 1-Oxa-3,5-dithiazatriquinane Derivatives and their Pharmacologies. Heterocycles. 97:687-695. doi: 10.3987/COM-18-S(T)40

2017

2017 Full List of Publications

1

Honjoh S, Ihara A, Kajiwara Y, Yamamoto T, Nishida E (2017) The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans. Cell Rep 21(13): 3646–3652. doi:10.1016/j.celrep.2017.11.108

2

Liu J, Zhang MQ, Wu X, Lazarus M, Cherasse Y, Yuan MY, Huang ZL, Li RX (2017) Activation of Parvalbumin Neurons in the Rostro-Dorsal Sector of the Thalamic Reticular Nucleus Promotes Sensitivity to Pain in Mice. Neuroscience 16(366): 113-123. doi:10.1016/j.neuroscience.2017.10.013

3

Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T (2017) Prostaglandin D-2 metabolite in urine is an index of food allergy. Sci Rep 7(1): 17687. doi:10.1038/s41598-017-17798-w

4

Ogawa Y, Kanda T, Vogt K, Yanagisawa M (2017) Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates. J. Comp. Neurol. 525(18): 3809-3820. doi:10.1002/cne.24261

5

Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB (2017) A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron 96(5): 1153-1167. doi:10.1016/j.neuron.2017.10.009

6

Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y (2017) Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction. FEBS Lett. 591(24): 4067-4073. doi:10.1002/1873-3468.12914

7

Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y, Fujii R, Usui T, Kulathunga K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T, Takahashi S (2017) MafB is a critical regulator of complement component C1q. Nat. Commun. 8(1): 1700. doi:10.1038/s41467-017-01711-0

8

Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017) Orexin modulates behavioral fear expression through the locus coeruleus. Nat. Commun. 8(1): 1606. doi:10.1038/s41467-017-01782-z

9

Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S (2017) T cells upon activation promote endothelin 1 production in monocytes via IFN-gamma and TNF-alpha. Sci Rep 7(1): 14500. doi:10.1038/s41598-017-14202-5

10

Um MY, Kim S, Jin YH, Yoon M, Yang H, Lee J, Jung J, Urade Y, Huang ZL, Kwon S, Cho S (2017) A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H-1 receptors. Mol. Nutr. Food. Res. 61(11). doi:10.1002/mnfr.201700316

11

Kutsumura N, Shibuya K, Yamaguchi H, Saito T (2017) n-Butyllithium-promoted regioselective elimination of vicinal bis-triflate having an adjacent ether oxygen. Tetrahedron Lett. 58(43): 4099–4102. doi:10.1016/j.tetlet.2017.09.036

12

Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M (2017) Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development 144(20): 3706-3718. doi:10.1242/dev.150755

13

Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d’Exaerde AD, Li RX, Huang ZL (2017) Striatal adenosine A(2A) receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife 6: e29055. doi:10.7554/eLife.29055

14

Suda H, Kanbayashi T, Ito SU, Sagawa Y, Imanishi A, Tsutsui K, Takahashi J, Kikuchi Y, Takahashi Y, Shimizu T (2017) Residual effects of eszopiclone on daytime alertness, psychomotor, physical performance and subjective evaluations. Sleep Biol Rhythms 15(4): 311–316. doi:10.1007/s41105-017-0112-z

15

Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schiffmann SN, d’Exaerde AD, Urade Y, Qu WM, Huang ZL, Lazarus M (2017) Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nat. Commun. 8(1): 734. doi:10.1038/s41467-017-00781-4

16

Yamamoto N, Okada T, Harada Y, Kutsumura N, Imaide S, Saitoh T, Fujii H, Nagase H (2017) The application of a specific morphinan template to the synthesis of galanthamine. Tetrahedron. 73(39): 5751-5758. doi:10.1016/j.tet.2017.08.014

17

Fujii H, Shimada N, Ohtawa M, Karaki F, Koshizuka M, Hayashida K, Kamimura M, Makino K, Nagamitsu T, Nagase H (2017) Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives. Tetrahedron 73(36): 5425-5429. doi:10.1016/j.tet.2017.07.047

18

Malyshevskaya O, Aritake K, Kaushik MK, Uchiyama N, Cherasse Y, Kikura-Hanajiri R, Urade Y (2017) Natural (Delta(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Sci Rep 7(1): 10516. doi:10.1038/s41598-017-10447-2

19

Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2017) Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor. Bioorg. Med. Chem. Lett. 27(17): 4176-4179. doi:10.1016/j.bmcl.2017.07.011

20

Tsuneoka Y, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse. Sci Rep 7(1): 9809. doi:10.1038/s41598-017-10213-4

21

Kutsumura N, Ohshita R, Horiuchi J, Tateno K, Yamamoto N, Saitoh T, Nagumo Y, Kawai H, Nagase H (2017) Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon. Tetrahedron 73(34): 5214-5219. doi:10.1016/j.tet.2017.07.016

22

Kaushik MK, Aritake K, Takeuchi A, Yanagisawa M, Urade Y (2017) Octacosanol restores stress-affected sleep in mice by alleviating stress. Sci Rep 7(1): 8892. doi:10.1038/s41598-017-08874-2

23

Wakai E, Aritake K, Urade Y, Fujimori K (2017) Prostaglandin D-2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Biochem. Biophys. Res. Commun. 490(2): 393-399. doi:10.1016/j.bbrc.2017.06.053

24

Kutsumura N, Koyama Y, Nagumo Y, Nakajima R, Miyata Y, Yamamoto N, Saitoh T, Yoshida N, Iwata S, Nagase H (2017) Antitrichomonal activity of delta opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. Bioorg. Med. Chem. 25(16): 4375-4383. doi:10.1016/j.bmc.2017.06.026

25

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T (2017) Mast cell-derived prostaglandin D-2 attenuates anaphylactic reactions in mice. J. Allergy Clin. Immunol. 140(2): 630–632.e9. doi:10.1016/j.jaci.2017.02.030

26

Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M (2017) Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D-2-like receptors in mice. Brain Struct. Funct. 222(6): 2907-2915. doi:10.1007/s00429-017-1365-7

27

Watanabe Y, Hayashida K, Saito D, Takahashi T, Sakai J, Nakata E, Kanda T, Iwai T, Hirayama S, Fujii H, Yamakawa T, Nagase H (2017) Design and synthesis of novel delta opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration. Bioorg. Med. Chem. Lett. 27(15): 3495-3498. doi:10.1016/j.bmcl.2017.05.072

28

Shitara H, Cao LQ, Yamaguchi M, Yonekawa H, Taya C (2017) Establishment of a heteroplasmic mouse strain with interspecific mitochondrial DNA haplotypes and improvement of a PCR-RFLP-based measurement system for estimation of mitochondrial DNA heteroplasmy. Transgenic Res. 26(4): 559-565. doi:10.1007/s11248-017-0009-2

29

Kodani S, Soya S, Sakurai T (2017) Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice. J. Neurosci. 37(30): 7164-7176. doi:10.1523/JNEUROSCI.0245-17.2017

30

Iwayama K, Kawabuchi R, Nabekura Y, Kurihara R, Park I, Kobayashi M, Ogata H, Kayaba M, Omi N, Satoh M, Tokuyama K (2017) Exercise before breakfast increases 24-h fat oxidation in female subjects. PLoS One 12(7): e0180472. doi:10.1371/journal.pone.0180472

31

Takahashi J, Kanbayashi T, Uemura SI, Sagawa Y, Tsutsui K, Takahashi Y, Omori Y, Imanishi A, Takeshima M, Satake M, Shimizu T (2017) Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study. Sleep Biol. Rhythms 15(3): 235-241. doi:10.1007/s41105-017-0101-2

32

Takei K, Han S, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H (2017) Selective peroxisome proliferator-activated receptor-alpha modulator K-877 efficiently activates the peroxisome proliferatoractivated receptor-alpha pathway and improves lipid metabolism in mice. J. Diabetes. Investig. 8(4): 446- 452. doi:10.1111/jdi.12621

33

Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han S, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N Shimano H (2017) Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity. Diabetes 66(7): 1833-1846. doi:10.2337/db16-1277

34

Hayashida K, Hirayama S, Iwai T, Watanabe Y, Takahashi T, Sakai J, Nakata E, Yamakawa T, Fujii H, Nagase H (2017) Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities. Bioorg. Med. Chem. Lett. 27(12): 2742-2745. doi:10.1016/j.bmcl.2017.04.059

35

Ku CJ, Sekiguchi JM, Panwar B, Guan YF, Takahashi S, Yoh K, Maillard I, Hosoya T, Engel JD (2017) GATA3 Abundance Is a Critical Determinant of T Cell Receptor beta Allelic Exclusion. Mol. Cell. Biol. 37(12): e00052-17. doi:10.1128/MCB.00052-17

36

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc. Natl. Acad. Sci. U.S.A. 114(22): 5731-5736. doi:10.1073/pnas.1700499114

37

Saito H, Cherasse Y, Suzuki R, Mitarai M, Ueda F, Urade Y (2017) Zinc-rich oysters as well as zinc-yeastand astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals. Mol. Nutr. Food. Res. 61(5). doi:10.1002/mnfr.201600882

38

Toyama T, Saitoh T, Takahashi Y, Oka K, Citterio D, Suzuki K, Nishiyama S (2017) Click Reaction Based on the Biosynthesis of Firefly Luciferin. Chem. Lett. 46(5): 753-755. doi:10.1246/cl.170094

39

Li JJ, Kong DP, Wang Q, Wu W, Tang YP, Bai TT, Guo L, Wei LM, Zhang QQ, Yu Y, Qian YT, Zuo SK, Liu, GZ, Liu, Q, Wu, S, Zang, Y, Zhu, Q, Jia DL, Wang YY, Yao WY, Ji Y, Yin HY, Nakamura M, Lazarus M, Breyer RM, Wang LF, Yu Y (2017) Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation. EMBO Mol. Med. 9(5): 571-588. doi:10.15252/emmm.201606987

40

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat. Chem. Biol. 13(5): 529-536. doi:10.1038/nchembio.2334

41

Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M (2017) Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity. Proc. Natl. Acad. Sci. U.S.A. 114(17): E3526-E3535. doi:10.1073/pnas.1614552114

42

Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani K, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M (2017) Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Sci Rep 7: 46597. doi:10.1038/srep46597

43

Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M (2017) Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav. Brain Res. 323: 11-14. doi:10.1016/j.bbr.2016.11.008

44

Purple RJ, Sakurai T, Sakaguchi M (2017) Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice. Sci Rep 7: 46247. doi:10.1038/srep46247

45

Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y (2017) Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One 12(4): e0175452. doi:10.1371/journal.pone.0175452

46

Takei K, Nakagawa Y, Wang Y, Han S, Satoh A, Sekiya M, Matsuzaka T, Shimano H (2017) Effects of K-877, a novel selective PPAR alpha modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. J. Pharmacol. Sci. 133(4): 214-222. doi:10.1016/j.jphs.2017.02.003

47

Park I, Ochiai R, Ogata H, Kayaba M, Hari S, Hibi M, Katsuragi Y, Satoh M, Tokuyama K (2017) Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial. Br. J. Nutr. 117(7): 979-984. doi:10.1017/S0007114517000587

48

Wang YQ, Li R, Wang DR, Cherasse Y, Zhang Z, Zhang MQ, Lavielle O, McEown K, Schiffmann SN, d’Exaerde AD, Qu WM, Lazarus M, Huang ZL (2017) Adenosine A(2A) receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. Brain Struct. Funct. 222(3): 1351-1366. doi:10.1007/s00429-016-1281-2

49

Zhang BJ, Huang ZL, Chen JF, Urade Y, Qu WM (2017) Adenosine A(2A) receptor deficiency attenuates the somnogenic effect of prostaglandin D-2 in mice. Acta Pharmacol. Sin. 38(4): 469-476. doi:10.1038/aps.2016.140

50

Yokosawa M, Kondo Y, Tahara M, Iizuka-Koga M, Segawa S, Kaneko S, Tsuboi H, Yoh K, Takahashi S, Matsumoto I, Sumida T (2017) T-bet over-expression regulates aryl hydrocarbon receptor-mediated T helper type 17 differentiation through an interferon (IFN)-independent pathway. Clin. Exp. Immunol. 188(1): 22-35. doi:10.1111/cei.12912

51

Kayaba M, Park I, Iwayama K, Seya Y, Ogata H, Yajima K, Satoh M, Tokuyama K (2017) Energy metabolism differs between sleep stages and begins to increase prior to awakening. Metab. Clin. Exp. 69: 14-23. doi:10.1016/j.metabol.2016.12.016

52

Grewe BF, Grundemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Luthi A, Schnitzer MJ (2017) Neural ensemble dynamics underlying a long-term associative memory. Nature 543(7647): 670-675. doi:10.1038/nature21682

53

Tsuneoka Y, Tsukahara S, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala. Front. Neuroanat. 11: 26. doi:10.3389/fnana.2017.00026

54

Tang J, Shen YJ, Chen GL, Wan QY, Wang K, Zhang J, Qin J, Liu GZ, Zuo SK, Tao B, Yu Y, Wang JW, Lazarus M, Yu Y (2017) Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat. Commun. 8: 14656. doi:10.1038/ncomms14656

55

Kong DP, Li JJ, Shen YJ, Liu GZ, Zuo SK, Tao B, Ji Y, Lu AK, Lazarus M, Breyer RM, Yu Y (2017) Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1. J. Pharmacol. Exp. Ther. 360(3): 435-444. doi:10.1124/jpet.116.238261

56

Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A, Hosoya T, McHugh TJ, Kuwahara M, Itohara S (2017) Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Transl. Psychiatry 7(2): e1047. doi:10.1038/tp.2017.19

57

Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y (2017) Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One 12(2): e0172508. doi:10.1371/journal.pone.0172508

58

Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M (2017) Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. J. Med. Chem. 60(3): 1018-1040. doi:10.1021/acs.jmedchem.6b01418

59

Mieda M, Hasegawa E, Kessaris N, Sakurai T (2017) Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain. Front Neurosci 11: 55. doi:10.3389/fnins.2017.00055

60

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao JH, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK (2017) SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 25(2): 412-427. doi:10.1016/j.cmet.2016.11.009

61

Ohtaki Y, Oi Y, Doki S, Kaneko H, Usami K, Sasahara S, Matsuzaki I (2017) Characteristics of Telephone Crisis Hotline Callers with Suicidal Ideation in Japan. Suicide Life Threat. Behav. 47(1): 54-66. doi:10.1111/sltb.12264

62

Garcia SV, Libourel PA, Lazarus M, Grassi D, Luppi PH, Fort P (2017) Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Brain 140(2): 414-428. doi:10.1093/brain/aww310

63

Zhang BJ, Shag SR, Aritake K, Takeuchi A, Urade Y, Huang, ZL, Lazarus M, Qu WM (2017) Interleukin-1β induces sleep independent of prostaglandin D2 in rats and mice. Neuroscience 340: 258-267. doi:10.1016/j.neuroscience.2016.09.053

64

Korkutata M, Saitoh T, Feng D, Murakoshi N, Sugiyama F, Cherasse Y, Nagase H, Lazarus M (2017) Allosteric modulation of adenosine A2A receptors in mice induces slow-wave sleep without cardiovascular effects. Sleep Medicine 40: e181. doi:10.1016/j.sleep.2017.11.530

65

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T (2017) Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. doi:10.1038/mp.2017.177

66

Tsutsui K, Kanbayashi T, Takaki M, Omori Y, Imai Y, Nishino S, Tanaka K, Shimizu T (2017) N-Methyl-Daspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection. Neuropsychiatr Dis Treat. 13: 339–345. doi:10.2147/NDT.S125800

67

Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2017) Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features. Pathol Int. 68(1): 12-22. doi:10.1111/pin.12612

68

Hamada Y, Tasaki Y, Morita K, Yamamizu K, Narita M, Matsuyama F, Suzuki M, Ikegami D, Arakawa K, Nagumo Y, Kawata M, Uezono Y, Nagase H, Aoki K, Yamashita JK, Kuzumaki N, Narita M (2017) The κopioid receptor agonist nalfurafine enhances the chemotherapy-induced survival advantage in pancreatic cancer-bearing mice. Jpn. J. Pharm. Palliat. Care Sci 10: 7-12

2016

    

2016 Full List of Publications

1

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang ZQ, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu QH, Kume K, Wakana S, Takahashi JS, Yanagisawa M (2016) Forward-genetics analysis of sleep in randomly mutagenized mice. Nature 539(7629): 378-383. doi:10.1038/nature20142

2

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M (2016) Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Sci Rep 6: 34253. doi:10.1038/srep32453

3

Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H (2016) High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity. Obesity 24(4): 886-894. doi:10.1002/oby.21441

4

Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M, Smith CC, Fernandez G, Deisseroth K, Greene RW, Morris RGM (2016) Locus coeruleus and dopaminergic consolidation of everyday memory. Nature 537(7620): 357-362. doi:10.1038/nature19325

5

Bjorness TE, Dale N, Mettlach G, Sonneborn A, Sahin B, Fienberg AA, Yanagisawa M, Bibb JA, Greene RW (2016) An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep. J. Neurosci. 36(13): 3709-3721. doi:10.1523/JNEUROSCI.3906-15.2016

6

McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, Lazarus M (2016) Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. eLife 5: e20269. doi:10.7554/eLife.20269

7

Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S (2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports 17(9): 2405-2417. doi:10.1016/j.celrep.2016.10.088

8

Kong DP, Shen YJ, Liu GZ, Zuo SK, Ji Y, Lu AK, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y (2016) PKA regulatory II alpha subunit is essential for PGD(2)-mediated resolution of inflammation. J. Exp. Med. 213(10): 2209-2226. doi:10.1084/jem.20160459

9

Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM, Huang ZL (2016) Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice. Neuropsychopharmacology 41(8): 2133-2146. doi:10.1038/npp.2016.13

10

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Lofberg A, Jaarola M, Kugelberg UO, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schuetz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D (2016) Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation- induced aversion in mice. J. Clin. Invest. 126(2): 695-705. doi:10.1172/JCI83844

11

Fujinaka A, Li RS, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai T, Kee N, Nakajima S, Wang SH, Sakaguchi M (2016) Effect of context exposure after fear learning on memory generalization in mice. Mol. Brain 9:2 doi:10.1186/s13041-015-0184-0

12

Oishi Y, Takata Y, Taguchi Y, Kohtoh S, Urade Y, Lazarus M (2016) Polygraphic Recording Procedure for Measuring Sleep in Mice. J. Vis. Exp 107: e53678. doi:10.3791/53678

13

Doki S, Kaneko H, Oi Y, Usami K, Sasahara S, Matsuzaki I (2016) Risk Factors for Suicidal Ideation Among Telephone Crisis Hotline Callers in Japan. Crisis 37(6): 438-444. doi:10.1027/0227-5910/a000384

14

Doki S, Sasahara S, Oi Y, Matsuzaki I (2016) A survey of support systems for return to work in Japanese companies: a cross-sectional study. Ind. Health 54(6): 564-572. doi:10.2486/indhealth.2015-0185

15

Doki S, Sasahara S, Hirai Y, Oi Y, Matsuzaki I (2016) Absenteeism due to mental health problems and systems for return to work: an internet-based unmatched case-control study. Int. Arch. Occup. Environ. Health 89(8): 1279-1287. doi:10.1007/s00420-016-1162-2

16

Yajima S, Saitoh T, Kawa K, Nakamura K, Nagase H, Einaga Y, Nishiyama S (2016) Asymmetric induction in cyclohexadienones carrying alpha-D-glucopyranosyl moiety. Tetrahedron 72(51): 8428-8435. doi:10.1016/j.tet.2016.10.068

17

Kutsumura N, Koyama Y, Tateno K, Yamamoto N, Nagase H, Saito T (2016) ZnCl2-Promoted Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines. Chem. Pharm. Bull. 64(9): 1364-1369. doi:10.1248/cpb.c16-00363

18

Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H (2016) Odour-induced analgesia mediated by hypothalamic orexin neurons in mice. Sci Rep 6: 37129. doi:10.1038/srep37129

19

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T (2016) QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One 11(11): e0164716. doi:10.1371/journal.pone.0164716

20

Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka, T (2016) Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology 157(11): 4146-4157. doi:10.1210/en.2016- 1404

21

Mieda M, Okamoto H, Sakurai T (2016) Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period. Curr. Biol. 26(18): 2535-2542. doi:10.1016/j.cub.2016.07.022

22

Tsuneki H, Sasaoka T, Sakurai T. Sleep Control, GPCRs, and Glucose Metabolism (2016) Trends Endocrinol. Metab. 27(9): 633-642. doi:10.1016/j.tem.2016.06.011

23

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M (2016) Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc. Natl. Acad. Sci. U.S.A. 113(21): 6023-6028. doi:10.1073/pnas.1518658113

24

Tsuneki H, Nagata T, Fujita M, Kon K, Wu NZ, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T (2016) Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. Endocrinology 157(1): 195-206. doi:10.1210/en.2015-1488

25

Nakagawa Y, Satoh A, Tezuka H, Han S, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H (2016) CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPAR alpha. Sci Rep 6: 39182. doi:10.1038/srep39182

26

Sunaga H, Matsui H, Anjo S, Syamsunarno MRAA, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M (2016) Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kruppel-Like Factor 4 (AMPK/KLF4) Signaling. J. Am. Heart Assoc. 5(12): e004014. doi: 10.1161/JAHA.116.004014

27

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H (2016) Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Mol. Metab. 5(11): 1092-1102. doi:10.1016/j.molmet.2016.09.004

28

Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H (2016) Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. PLoS One 11(7): e0159375. doi:10.1371/journal.pone.0159375

29

Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han S, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H (2016) Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced NonAlcoholic Fatty Liver Disease in Mice. PLoS One 11(6): e0157580. doi:10.1371/journal.pone.0157580

30

Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han S, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H (2016) Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Sci Rep 6: 27857. doi:10.1038/srep27857

31

Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T (2016) Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with or without midbrain involvement A case series. Medicine(Baltimore) 95(29): e4281. doi:10.1097/MD.0000000000004281

32

Omokawa M, Ayabe T, Nagai T, Imanishi A, Omokawa A, Nishino S, Sagawa Y, Shimizu T, Kanbayashi T (2016) Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome. Am. J. Med. Genet. A 170(5): 1181-1186. doi:10.1002/ajmg.a.37542

33

Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M (2016) Peripherally administered orexin improves survival of mice with endotoxin shock. eLife 5: e21055. doi:10.7554/eLife.21055

34

Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M (2016) Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS One 11(7): e0159246. doi:10.1371/journal.pone.0159246

35

Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F (2016) Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice. Exp. Anim. 65 (3): 319-327. doi:10.1538/expainm.16-0016

36

Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, ElShemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F (2016) Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54(7): 389-397. doi:10.1002/dvg.22944

37

Tran MTN, Hamada M, Nakamura M, Jeon H, Kamei R, Tsunakawa Y, Kulathunga K, Lin YY, Fujisawa K, Kudo T, Takahashi S (2016) MafB deficiency accelerates the development of obesity in mice. FEBS Open Bio 6(6): 540-547. doi:10.1002/2211-5463.12058

38

Daassi D, Hamada M, Jeon H, Imamura Y, Tran MTN, Takahashi S (2016) Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem. Biophys. Res. Commun. 473(1): 118-124. doi:10.1016/j.bbrc.2016.03.063

39

Jeon H, Waku T, Azami T, Khoa LTP, Yanagisawa J, Takahashi S, Ema M (2016) Comprehensive Identification of Kruppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming. PLoS One 11(3): e0150715. doi:10.1371/journal.pone.0150715

40

Abdellatif’ AM, Oishi H, Itagaki T, Jung YS, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, ElSayed MA, Shoaib MB, Sugiyama F, Takahashi S (2016) beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One 11(2): e0150010. doi:10.1371/journal.pone.0150010

41

Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N (2016) Overexpression of ROR gamma t Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. PLoS One 11(1): e0147064. doi:10.1371/journal.pone.0147064

42

Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, Murata T (2016) Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One 11(12): e0167729. doi:10.1371/journal.pone.0167729

43

Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A(2A) receptors. J. Sleep Res. 25(6): 746-753. doi:10.1111/jsr.12434

44

Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial. J. Sleep Res. 25(1): 116-123. doi:10.1111/jsr.12336

45

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat. Commun. 7: 11613. doi:10.1038/ncomms11613

46

Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS (2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 311(2): R263-R271. doi:10.1152/ajpregu.00016.2015

47

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight 1(11): e87860. doi:10.1172/jci.insight.87680

48

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A (2016) Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res. Ther. 18(1): 113. doi:10.1186/s13075-016-1011-4

49

Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM (2016) Functional ETA-ETB Receptor Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats. J. Cardiovasc. Pharmacol. 67(3): 212- 217. doi:10.1097/FJC.0000000000000335

50

Kutsumura N, Numata K, Saito T (2016) First total synthesis of haplacutine C. Tetrahedron Lett. 57(50): 5581-5583. doi:10.1016/j.tetlet.2016.10.070

51

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG (2016) A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol. 11(12): 3383-3390. doi:10.1021/acschembio.6b00727

52

Ioka S, Saitoh T, Maki SA, Imoto M, Nishiyama S (2016) Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization. Tetrahedron 72(47): 7505-7508. doi:10.1016/j.tet.2016.09.069

53

Honda T, Lee CY, Honjo K, Furukubo-Tokunaga K (2016) Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae. Front. Behav. Neurosci. 10: 137. doi:10.3339/fnbeh.2016.00137

54

Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S (2016) Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties. Chem.-Eur. J. 22(27): 9330-9337. doi:10.1002/chem.201600278

55

Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J (2016) OPIOID SYSTEMS IN THE LATERAL HYPOTHALAMUS REGULATE FEEDING BEHAVIOR THROUGH OREXIN AND GABA NEURONS. Neuroscience 320(183): 193 doi: 10.1016/j.neuroscience.2016.02.002

2015

2015 Full List of Publications

1

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

2

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

3

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

4

Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB. The roles of prostaglandin E(2) and D(2) in lipopolysaccharide-mediated changes in sleep. Brain Behav Immun. 2014 Dec 20. pii: S0889- 1591(14)00564-9.

5

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

6

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

7

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

8

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014 Jun 15;522(9):2089-106.

9

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

10

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

11

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

12

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

13

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791-802.

14

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-13.

15

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697- 704.

16

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

17

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

18

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

19

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

20

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

21

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

22

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

23

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

24

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

25

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

26

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

27

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

28

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

29

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

30

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

31

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

32

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

33

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

34

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1-2):142-9.

35

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

36

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

37

Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I. Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun. 2014 Jul 18. pii: S0889- 1591(14)00400-0.

38

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

39

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

40

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563-77.

41

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

42

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

43

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and – independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

44

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

45

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

46

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

47

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

48

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

49

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

50

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

51

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

52

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

53

Doki S, Sasahara S, Matsuzaki I. Psychological approach of occupational health service to sick leave due to mental problems: a systematic review and meta-analysis. Int Arch Occup Environ Health. 2014 Nov 8.

54

Noriki Kutsumura, Shohei Toguchi, Masatoshi Iijima, Osamu Tanaka, Izumi Iwakura, Takao Saito, DBUpromoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups, Tetrahedron, Volume 70, Issue 43, 28 October 2014, Pages 8004-8009.

55

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

2014

2014 Full List of Publications

1

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

2

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

3

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

4

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

5

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

6

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

7

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

8

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

9

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

10

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

11

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791- 802.

12

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-

13

13. Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697-704.

14

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

15

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

16

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

17

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

18

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

19

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

20

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

21

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

22

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

23

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

24

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

25

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

26

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

27

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

28

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

29

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

30

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

31

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

32

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1- 2):142-9.

33

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

34

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

35

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

36

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

37

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563- 77.

38

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

39

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

40

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

41

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

42

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

43

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

44

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

45

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

46

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

47

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

48

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

49

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

50

Noriki K, Shohei T, Masatoshi I, Osamu T, Izumi I, Takao S. DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups. Tetrahedron. 2014 Oct 28;70:43:8004-8009.

51

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

52

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: The next generation. Life Sci. 2014 Aug 15.

53

Kashiwagi T, Fuchigami T, Saito T, Nishiyama S, Atobe M. Sequential paired electrosynthesis of a diaryl ether derivative using an electrochemical microreactor. Chem Lett. 2014 Jun 5;43(6):799-801.

2013

2013 Full List of Publications

1

Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013; 13 (6): 881-7.

2

Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K. Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice. G3 (Bethesda). 2013; 3 (9): 1545-52.

3

Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; 7: 43.

4

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