研究紹介論文一覧

2017

    

2017年 全論文一覧

1

Honjoh S, Ihara A, Kajiwara Y, Yamamoto T, Nishida E (2017) The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans. Cell Rep 21(13): 3646–3652. doi:10.1016/j.celrep.2017.11.108

2

Liu J, Zhang MQ, Wu X, Lazarus M, Cherasse Y, Yuan MY, Huang ZL, Li RX (2017) Activation of Parvalbumin Neurons in the Rostro-Dorsal Sector of the Thalamic Reticular Nucleus Promotes Sensitivity to Pain in Mice. Neuroscience 16(366): 113-123. doi:10.1016/j.neuroscience.2017.10.013

3

Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T (2017) Prostaglandin D-2 metabolite in urine is an index of food allergy. Sci Rep 7(1): 17687. doi:10.1038/s41598-017-17798-w

4

Ogawa Y, Kanda T, Vogt K, Yanagisawa M (2017) Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates. J. Comp. Neurol. 525(18): 3809-3820. doi:10.1002/cne.24261

5

Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB (2017) A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron 96(5): 1153-1167. doi:10.1016/j.neuron.2017.10.009

6

Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y (2017) Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction. FEBS Lett. 591(24): 4067-4073. doi:10.1002/1873-3468.12914

7

Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y, Fujii R, Usui T, Kulathunga K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T, Takahashi S (2017) MafB is a critical regulator of complement component C1q. Nat. Commun. 8(1): 1700. doi:10.1038/s41467-017-01711-0

8

Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017) Orexin modulates behavioral fear expression through the locus coeruleus. Nat. Commun. 8(1): 1606. doi:10.1038/s41467-017-01782-z

9

Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S (2017) T cells upon activation promote endothelin 1 production in monocytes via IFN-gamma and TNF-alpha. Sci Rep 7(1): 14500. doi:10.1038/s41598-017-14202-5

10

Um MY, Kim S, Jin YH, Yoon M, Yang H, Lee J, Jung J, Urade Y, Huang ZL, Kwon S, Cho S (2017) A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H-1 receptors. Mol. Nutr. Food. Res. 61(11). doi:10.1002/mnfr.201700316

11

Kutsumura N, Shibuya K, Yamaguchi H, Saito T (2017) n-Butyllithium-promoted regioselective elimination of vicinal bis-triflate having an adjacent ether oxygen. Tetrahedron Lett. 58(43): 4099–4102. doi:10.1016/j.tetlet.2017.09.036

12

Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M (2017) Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development 144(20): 3706-3718. doi:10.1242/dev.150755

13

Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d’Exaerde AD, Li RX, Huang ZL (2017) Striatal adenosine A(2A) receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife 6: e29055. doi:10.7554/eLife.29055

14

Suda H, Kanbayashi T, Ito SU, Sagawa Y, Imanishi A, Tsutsui K, Takahashi J, Kikuchi Y, Takahashi Y, Shimizu T (2017) Residual effects of eszopiclone on daytime alertness, psychomotor, physical performance and subjective evaluations. Sleep Biol Rhythms 15(4): 311–316. doi:10.1007/s41105-017-0112-z

15

Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schiffmann SN, d’Exaerde AD, Urade Y, Qu WM, Huang ZL, Lazarus M (2017) Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nat. Commun. 8(1): 734. doi:10.1038/s41467-017-00781-4

16

Yamamoto N, Okada T, Harada Y, Kutsumura N, Imaide S, Saitoh T, Fujii H, Nagase H (2017) The application of a specific morphinan template to the synthesis of galanthamine. Tetrahedron. 73(39): 5751-5758. doi:10.1016/j.tet.2017.08.014

17

Fujii H, Shimada N, Ohtawa M, Karaki F, Koshizuka M, Hayashida K, Kamimura M, Makino K, Nagamitsu T, Nagase H (2017) Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives. Tetrahedron 73(36): 5425-5429. doi:10.1016/j.tet.2017.07.047

18

Malyshevskaya O, Aritake K, Kaushik MK, Uchiyama N, Cherasse Y, Kikura-Hanajiri R, Urade Y (2017) Natural (Delta(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Sci Rep 7(1): 10516. doi:10.1038/s41598-017-10447-2

19

Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2017) Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor. Bioorg. Med. Chem. Lett. 27(17): 4176-4179. doi:10.1016/j.bmcl.2017.07.011

20

Tsuneoka Y, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse. Sci Rep 7(1): 9809. doi:10.1038/s41598-017-10213-4

21

Kutsumura N, Ohshita R, Horiuchi J, Tateno K, Yamamoto N, Saitoh T, Nagumo Y, Kawai H, Nagase H (2017) Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon. Tetrahedron 73(34): 5214-5219. doi:10.1016/j.tet.2017.07.016

22

Kaushik MK, Aritake K, Takeuchi A, Yanagisawa M, Urade Y (2017) Octacosanol restores stress-affected sleep in mice by alleviating stress. Sci Rep 7(1): 8892. doi:10.1038/s41598-017-08874-2

23

Wakai E, Aritake K, Urade Y, Fujimori K (2017) Prostaglandin D-2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Biochem. Biophys. Res. Commun. 490(2): 393-399. doi:10.1016/j.bbrc.2017.06.053

24

Kutsumura N, Koyama Y, Nagumo Y, Nakajima R, Miyata Y, Yamamoto N, Saitoh T, Yoshida N, Iwata S, Nagase H (2017) Antitrichomonal activity of delta opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. Bioorg. Med. Chem. 25(16): 4375-4383. doi:10.1016/j.bmc.2017.06.026

25

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T (2017) Mast cell-derived prostaglandin D-2 attenuates anaphylactic reactions in mice. J. Allergy Clin. Immunol. 140(2): 630–632.e9. doi:10.1016/j.jaci.2017.02.030

26

Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M (2017) Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D-2-like receptors in mice. Brain Struct. Funct. 222(6): 2907-2915. doi:10.1007/s00429-017-1365-7

27

Watanabe Y, Hayashida K, Saito D, Takahashi T, Sakai J, Nakata E, Kanda T, Iwai T, Hirayama S, Fujii H, Yamakawa T, Nagase H (2017) Design and synthesis of novel delta opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration. Bioorg. Med. Chem. Lett. 27(15): 3495-3498. doi:10.1016/j.bmcl.2017.05.072

28

Shitara H, Cao LQ, Yamaguchi M, Yonekawa H, Taya C (2017) Establishment of a heteroplasmic mouse strain with interspecific mitochondrial DNA haplotypes and improvement of a PCR-RFLP-based measurement system for estimation of mitochondrial DNA heteroplasmy. Transgenic Res. 26(4): 559-565. doi:10.1007/s11248-017-0009-2

29

Kodani S, Soya S, Sakurai T (2017) Excitation of GABAergic Neurons in the Bed Nucleus of the Stria Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice. J. Neurosci. 37(30): 7164-7176. doi:10.1523/JNEUROSCI.0245-17.2017

30

Iwayama K, Kawabuchi R, Nabekura Y, Kurihara R, Park I, Kobayashi M, Ogata H, Kayaba M, Omi N, Satoh M, Tokuyama K (2017) Exercise before breakfast increases 24-h fat oxidation in female subjects. PLoS One 12(7): e0180472. doi:10.1371/journal.pone.0180472

31

Takahashi J, Kanbayashi T, Uemura SI, Sagawa Y, Tsutsui K, Takahashi Y, Omori Y, Imanishi A, Takeshima M, Satake M, Shimizu T (2017) Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study. Sleep Biol. Rhythms 15(3): 235-241. doi:10.1007/s41105-017-0101-2

32

Takei K, Han S, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H (2017) Selective peroxisome proliferator-activated receptor-alpha modulator K-877 efficiently activates the peroxisome proliferatoractivated receptor-alpha pathway and improves lipid metabolism in mice. J. Diabetes. Investig. 8(4): 446- 452. doi:10.1111/jdi.12621

33

Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han S, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N Shimano H (2017) Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity. Diabetes 66(7): 1833-1846. doi:10.2337/db16-1277

34

Hayashida K, Hirayama S, Iwai T, Watanabe Y, Takahashi T, Sakai J, Nakata E, Yamakawa T, Fujii H, Nagase H (2017) Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities. Bioorg. Med. Chem. Lett. 27(12): 2742-2745. doi:10.1016/j.bmcl.2017.04.059

35

Ku CJ, Sekiguchi JM, Panwar B, Guan YF, Takahashi S, Yoh K, Maillard I, Hosoya T, Engel JD (2017) GATA3 Abundance Is a Critical Determinant of T Cell Receptor beta Allelic Exclusion. Mol. Cell. Biol. 37(12): e00052-17. doi:10.1128/MCB.00052-17

36

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc. Natl. Acad. Sci. U.S.A. 114(22): 5731-5736. doi:10.1073/pnas.1700499114

37

Saito H, Cherasse Y, Suzuki R, Mitarai M, Ueda F, Urade Y (2017) Zinc-rich oysters as well as zinc-yeastand astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals. Mol. Nutr. Food. Res. 61(5). doi:10.1002/mnfr.201600882

38

Toyama T, Saitoh T, Takahashi Y, Oka K, Citterio D, Suzuki K, Nishiyama S (2017) Click Reaction Based on the Biosynthesis of Firefly Luciferin. Chem. Lett. 46(5): 753-755. doi:10.1246/cl.170094

39

Li JJ, Kong DP, Wang Q, Wu W, Tang YP, Bai TT, Guo L, Wei LM, Zhang QQ, Yu Y, Qian YT, Zuo SK, Liu, GZ, Liu, Q, Wu, S, Zang, Y, Zhu, Q, Jia DL, Wang YY, Yao WY, Ji Y, Yin HY, Nakamura M, Lazarus M, Breyer RM, Wang LF, Yu Y (2017) Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation. EMBO Mol. Med. 9(5): 571-588. doi:10.15252/emmm.201606987

40

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat. Chem. Biol. 13(5): 529-536. doi:10.1038/nchembio.2334

41

Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M (2017) Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity. Proc. Natl. Acad. Sci. U.S.A. 114(17): E3526-E3535. doi:10.1073/pnas.1614552114

42

Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani K, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M (2017) Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Sci Rep 7: 46597. doi:10.1038/srep46597

43

Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M (2017) Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav. Brain Res. 323: 11-14. doi:10.1016/j.bbr.2016.11.008

44

Purple RJ, Sakurai T, Sakaguchi M (2017) Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice. Sci Rep 7: 46247. doi:10.1038/srep46247

45

Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y (2017) Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One 12(4): e0175452. doi:10.1371/journal.pone.0175452

46

Takei K, Nakagawa Y, Wang Y, Han S, Satoh A, Sekiya M, Matsuzaka T, Shimano H (2017) Effects of K-877, a novel selective PPAR alpha modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. J. Pharmacol. Sci. 133(4): 214-222. doi:10.1016/j.jphs.2017.02.003

47

Park I, Ochiai R, Ogata H, Kayaba M, Hari S, Hibi M, Katsuragi Y, Satoh M, Tokuyama K (2017) Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial. Br. J. Nutr. 117(7): 979-984. doi:10.1017/S0007114517000587

48

Wang YQ, Li R, Wang DR, Cherasse Y, Zhang Z, Zhang MQ, Lavielle O, McEown K, Schiffmann SN, d’Exaerde AD, Qu WM, Lazarus M, Huang ZL (2017) Adenosine A(2A) receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. Brain Struct. Funct. 222(3): 1351-1366. doi:10.1007/s00429-016-1281-2

49

Zhang BJ, Huang ZL, Chen JF, Urade Y, Qu WM (2017) Adenosine A(2A) receptor deficiency attenuates the somnogenic effect of prostaglandin D-2 in mice. Acta Pharmacol. Sin. 38(4): 469-476. doi:10.1038/aps.2016.140

50

Yokosawa M, Kondo Y, Tahara M, Iizuka-Koga M, Segawa S, Kaneko S, Tsuboi H, Yoh K, Takahashi S, Matsumoto I, Sumida T (2017) T-bet over-expression regulates aryl hydrocarbon receptor-mediated T helper type 17 differentiation through an interferon (IFN)-independent pathway. Clin. Exp. Immunol. 188(1): 22-35. doi:10.1111/cei.12912

51

Kayaba M, Park I, Iwayama K, Seya Y, Ogata H, Yajima K, Satoh M, Tokuyama K (2017) Energy metabolism differs between sleep stages and begins to increase prior to awakening. Metab. Clin. Exp. 69: 14-23. doi:10.1016/j.metabol.2016.12.016

52

Grewe BF, Grundemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Luthi A, Schnitzer MJ (2017) Neural ensemble dynamics underlying a long-term associative memory. Nature 543(7647): 670-675. doi:10.1038/nature21682

53

Tsuneoka Y, Tsukahara S, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala. Front. Neuroanat. 11: 26. doi:10.3389/fnana.2017.00026

54

Tang J, Shen YJ, Chen GL, Wan QY, Wang K, Zhang J, Qin J, Liu GZ, Zuo SK, Tao B, Yu Y, Wang JW, Lazarus M, Yu Y (2017) Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat. Commun. 8: 14656. doi:10.1038/ncomms14656

55

Kong DP, Li JJ, Shen YJ, Liu GZ, Zuo SK, Tao B, Ji Y, Lu AK, Lazarus M, Breyer RM, Yu Y (2017) Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1. J. Pharmacol. Exp. Ther. 360(3): 435-444. doi:10.1124/jpet.116.238261

56

Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A, Hosoya T, McHugh TJ, Kuwahara M, Itohara S (2017) Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Transl. Psychiatry 7(2): e1047. doi:10.1038/tp.2017.19

57

Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y (2017) Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One 12(2): e0172508. doi:10.1371/journal.pone.0172508

58

Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M (2017) Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. J. Med. Chem. 60(3): 1018-1040. doi:10.1021/acs.jmedchem.6b01418

59

Mieda M, Hasegawa E, Kessaris N, Sakurai T (2017) Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain. Front Neurosci 11: 55. doi:10.3389/fnins.2017.00055

60

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao JH, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK (2017) SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 25(2): 412-427. doi:10.1016/j.cmet.2016.11.009

61

Ohtaki Y, Oi Y, Doki S, Kaneko H, Usami K, Sasahara S, Matsuzaki I (2017) Characteristics of Telephone Crisis Hotline Callers with Suicidal Ideation in Japan. Suicide Life Threat. Behav. 47(1): 54-66. doi:10.1111/sltb.12264

62

Garcia SV, Libourel PA, Lazarus M, Grassi D, Luppi PH, Fort P (2017) Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Brain 140(2): 414-428. doi:10.1093/brain/aww310

63

Zhang BJ, Shag SR, Aritake K, Takeuchi A, Urade Y, Huang, ZL, Lazarus M, Qu WM (2017) Interleukin-1β induces sleep independent of prostaglandin D2 in rats and mice. Neuroscience 340: 258-267. doi:10.1016/j.neuroscience.2016.09.053

64

Korkutata M, Saitoh T, Feng D, Murakoshi N, Sugiyama F, Cherasse Y, Nagase H, Lazarus M (2017) Allosteric modulation of adenosine A2A receptors in mice induces slow-wave sleep without cardiovascular effects. Sleep Medicine 40: e181. doi:10.1016/j.sleep.2017.11.530

65

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T (2017) Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. doi:10.1038/mp.2017.177

66

Tsutsui K, Kanbayashi T, Takaki M, Omori Y, Imai Y, Nishino S, Tanaka K, Shimizu T (2017) N-Methyl-Daspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection. Neuropsychiatr Dis Treat. 13: 339–345. doi:10.2147/NDT.S125800

67

Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2017) Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features. Pathol Int. 68(1): 12-22. doi:10.1111/pin.12612

68

Hamada Y, Tasaki Y, Morita K, Yamamizu K, Narita M, Matsuyama F, Suzuki M, Ikegami D, Arakawa K, Nagumo Y, Kawata M, Uezono Y, Nagase H, Aoki K, Yamashita JK, Kuzumaki N, Narita M (2017) The κopioid receptor agonist nalfurafine enhances the chemotherapy-induced survival advantage in pancreatic cancer-bearing mice. Jpn. J. Pharm. Palliat. Care Sci 10: 7-12

2016

2016年 全論文一覧

1

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang ZQ, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu QH, Kume K, Wakana S, Takahashi JS, Yanagisawa M (2016) Forward-genetics analysis of sleep in randomly mutagenized mice. Nature 539(7629): 378-383. doi:10.1038/nature20142

2

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M (2016) Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Sci Rep 6: 34253. doi:10.1038/srep32453

3

Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H (2016) High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity. Obesity 24(4): 886-894. doi:10.1002/oby.21441

4

Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M, Smith CC, Fernandez G, Deisseroth K, Greene RW, Morris RGM (2016) Locus coeruleus and dopaminergic consolidation of everyday memory. Nature 537(7620): 357-362. doi:10.1038/nature19325

5

Bjorness TE, Dale N, Mettlach G, Sonneborn A, Sahin B, Fienberg AA, Yanagisawa M, Bibb JA, Greene RW (2016) An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep. J. Neurosci. 36(13): 3709-3721. doi:10.1523/JNEUROSCI.3906-15.2016

6

McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, Lazarus M (2016) Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. eLife 5: e20269. doi:10.7554/eLife.20269

7

Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S (2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports 17(9): 2405-2417. doi:10.1016/j.celrep.2016.10.088

8

Kong DP, Shen YJ, Liu GZ, Zuo SK, Ji Y, Lu AK, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y (2016) PKA regulatory II alpha subunit is essential for PGD(2)-mediated resolution of inflammation. J. Exp. Med. 213(10): 2209-2226. doi:10.1084/jem.20160459

9

Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM, Huang ZL (2016) Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice. Neuropsychopharmacology 41(8): 2133-2146. doi:10.1038/npp.2016.13

10

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Lofberg A, Jaarola M, Kugelberg UO, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schuetz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D (2016) Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation- induced aversion in mice. J. Clin. Invest. 126(2): 695-705. doi:10.1172/JCI83844

11

Fujinaka A, Li RS, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai T, Kee N, Nakajima S, Wang SH, Sakaguchi M (2016) Effect of context exposure after fear learning on memory generalization in mice. Mol. Brain 9:2 doi:10.1186/s13041-015-0184-0

12

Oishi Y, Takata Y, Taguchi Y, Kohtoh S, Urade Y, Lazarus M (2016) Polygraphic Recording Procedure for Measuring Sleep in Mice. J. Vis. Exp 107: e53678. doi:10.3791/53678

13

Doki S, Kaneko H, Oi Y, Usami K, Sasahara S, Matsuzaki I (2016) Risk Factors for Suicidal Ideation Among Telephone Crisis Hotline Callers in Japan. Crisis 37(6): 438-444. doi:10.1027/0227-5910/a000384

14

Doki S, Sasahara S, Oi Y, Matsuzaki I (2016) A survey of support systems for return to work in Japanese companies: a cross-sectional study. Ind. Health 54(6): 564-572. doi:10.2486/indhealth.2015-0185

15

Doki S, Sasahara S, Hirai Y, Oi Y, Matsuzaki I (2016) Absenteeism due to mental health problems and systems for return to work: an internet-based unmatched case-control study. Int. Arch. Occup. Environ. Health 89(8): 1279-1287. doi:10.1007/s00420-016-1162-2

16

Yajima S, Saitoh T, Kawa K, Nakamura K, Nagase H, Einaga Y, Nishiyama S (2016) Asymmetric induction in cyclohexadienones carrying alpha-D-glucopyranosyl moiety. Tetrahedron 72(51): 8428-8435. doi:10.1016/j.tet.2016.10.068

17

Kutsumura N, Koyama Y, Tateno K, Yamamoto N, Nagase H, Saito T (2016) ZnCl2-Promoted Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines. Chem. Pharm. Bull. 64(9): 1364-1369. doi:10.1248/cpb.c16-00363

18

Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H (2016) Odour-induced analgesia mediated by hypothalamic orexin neurons in mice. Sci Rep 6: 37129. doi:10.1038/srep37129

19

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T (2016) QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One 11(11): e0164716. doi:10.1371/journal.pone.0164716

20

Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka, T (2016) Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology 157(11): 4146-4157. doi:10.1210/en.2016- 1404

21

Mieda M, Okamoto H, Sakurai T (2016) Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period. Curr. Biol. 26(18): 2535-2542. doi:10.1016/j.cub.2016.07.022

22

Tsuneki H, Sasaoka T, Sakurai T. Sleep Control, GPCRs, and Glucose Metabolism (2016) Trends Endocrinol. Metab. 27(9): 633-642. doi:10.1016/j.tem.2016.06.011

23

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M (2016) Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc. Natl. Acad. Sci. U.S.A. 113(21): 6023-6028. doi:10.1073/pnas.1518658113

24

Tsuneki H, Nagata T, Fujita M, Kon K, Wu NZ, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T (2016) Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. Endocrinology 157(1): 195-206. doi:10.1210/en.2015-1488

25

Nakagawa Y, Satoh A, Tezuka H, Han S, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H (2016) CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPAR alpha. Sci Rep 6: 39182. doi:10.1038/srep39182

26

Sunaga H, Matsui H, Anjo S, Syamsunarno MRAA, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M (2016) Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kruppel-Like Factor 4 (AMPK/KLF4) Signaling. J. Am. Heart Assoc. 5(12): e004014. doi: 10.1161/JAHA.116.004014

27

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H (2016) Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Mol. Metab. 5(11): 1092-1102. doi:10.1016/j.molmet.2016.09.004

28

Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H (2016) Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. PLoS One 11(7): e0159375. doi:10.1371/journal.pone.0159375

29

Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han S, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H (2016) Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced NonAlcoholic Fatty Liver Disease in Mice. PLoS One 11(6): e0157580. doi:10.1371/journal.pone.0157580

30

Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han S, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H (2016) Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Sci Rep 6: 27857. doi:10.1038/srep27857

31

Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T (2016) Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with or without midbrain involvement A case series. Medicine(Baltimore) 95(29): e4281. doi:10.1097/MD.0000000000004281

32

Omokawa M, Ayabe T, Nagai T, Imanishi A, Omokawa A, Nishino S, Sagawa Y, Shimizu T, Kanbayashi T (2016) Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome. Am. J. Med. Genet. A 170(5): 1181-1186. doi:10.1002/ajmg.a.37542

33

Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M (2016) Peripherally administered orexin improves survival of mice with endotoxin shock. eLife 5: e21055. doi:10.7554/eLife.21055

34

Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M (2016) Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS One 11(7): e0159246. doi:10.1371/journal.pone.0159246

35

Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F (2016) Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice. Exp. Anim. 65 (3): 319-327. doi:10.1538/expainm.16-0016

36

Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, ElShemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F (2016) Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54(7): 389-397. doi:10.1002/dvg.22944

37

Tran MTN, Hamada M, Nakamura M, Jeon H, Kamei R, Tsunakawa Y, Kulathunga K, Lin YY, Fujisawa K, Kudo T, Takahashi S (2016) MafB deficiency accelerates the development of obesity in mice. FEBS Open Bio 6(6): 540-547. doi:10.1002/2211-5463.12058

38

Daassi D, Hamada M, Jeon H, Imamura Y, Tran MTN, Takahashi S (2016) Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem. Biophys. Res. Commun. 473(1): 118-124. doi:10.1016/j.bbrc.2016.03.063

39

Jeon H, Waku T, Azami T, Khoa LTP, Yanagisawa J, Takahashi S, Ema M (2016) Comprehensive Identification of Kruppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming. PLoS One 11(3): e0150715. doi:10.1371/journal.pone.0150715

40

Abdellatif’ AM, Oishi H, Itagaki T, Jung YS, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, ElSayed MA, Shoaib MB, Sugiyama F, Takahashi S (2016) beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One 11(2): e0150010. doi:10.1371/journal.pone.0150010

41

Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N (2016) Overexpression of ROR gamma t Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. PLoS One 11(1): e0147064. doi:10.1371/journal.pone.0147064

42

Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, Murata T (2016) Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One 11(12): e0167729. doi:10.1371/journal.pone.0167729

43

Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A(2A) receptors. J. Sleep Res. 25(6): 746-753. doi:10.1111/jsr.12434

44

Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial. J. Sleep Res. 25(1): 116-123. doi:10.1111/jsr.12336

45

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat. Commun. 7: 11613. doi:10.1038/ncomms11613

46

Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS (2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 311(2): R263-R271. doi:10.1152/ajpregu.00016.2015

47

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight 1(11): e87860. doi:10.1172/jci.insight.87680

48

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A (2016) Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res. Ther. 18(1): 113. doi:10.1186/s13075-016-1011-4

49

Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM (2016) Functional ETA-ETB Receptor Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats. J. Cardiovasc. Pharmacol. 67(3): 212- 217. doi:10.1097/FJC.0000000000000335

50

Kutsumura N, Numata K, Saito T (2016) First total synthesis of haplacutine C. Tetrahedron Lett. 57(50): 5581-5583. doi:10.1016/j.tetlet.2016.10.070

51

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG (2016) A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol. 11(12): 3383-3390. doi:10.1021/acschembio.6b00727

52

Ioka S, Saitoh T, Maki SA, Imoto M, Nishiyama S (2016) Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization. Tetrahedron 72(47): 7505-7508. doi:10.1016/j.tet.2016.09.069

53

Honda T, Lee CY, Honjo K, Furukubo-Tokunaga K (2016) Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae. Front. Behav. Neurosci. 10: 137. doi:10.3339/fnbeh.2016.00137

54

Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S (2016) Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties. Chem.-Eur. J. 22(27): 9330-9337. doi:10.1002/chem.201600278

55

Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J (2016) OPIOID SYSTEMS IN THE LATERAL HYPOTHALAMUS REGULATE FEEDING BEHAVIOR THROUGH OREXIN AND GABA NEURONS. Neuroscience 320(183): 193 doi: 10.1016/j.neuroscience.2016.02.002

 

2015

2015年 全論文一覧

1

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

2

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

3

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

4

Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB. The roles of prostaglandin E(2) and D(2) in lipopolysaccharide-mediated changes in sleep. Brain Behav Immun. 2014 Dec 20. pii: S0889- 1591(14)00564-9.

5

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

6

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

7

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

8

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014 Jun 15;522(9):2089-106.

9

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

10

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

11

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

12

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

13

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791-802.

14

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-13.

15

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697- 704.

16

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

17

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

18

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

19

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

20

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

21

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

22

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

23

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

24

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

25

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

26

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

27

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

28

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

29

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

30

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

31

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

32

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

33

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

34

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1-2):142-9.

35

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

36

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

37

Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I. Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun. 2014 Jul 18. pii: S0889- 1591(14)00400-0.

38

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

39

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

40

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563-77.

41

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

42

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

43

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and – independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

44

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

45

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

46

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

47

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

48

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

49

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

50

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

51

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

52

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

53

Doki S, Sasahara S, Matsuzaki I. Psychological approach of occupational health service to sick leave due to mental problems: a systematic review and meta-analysis. Int Arch Occup Environ Health. 2014 Nov 8.

54

Noriki Kutsumura, Shohei Toguchi, Masatoshi Iijima, Osamu Tanaka, Izumi Iwakura, Takao Saito, DBUpromoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups, Tetrahedron, Volume 70, Issue 43, 28 October 2014, Pages 8004-8009.

55

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

2014

2014年 全論文一覧

1

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

2

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

3

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

4

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

5

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

6

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

7

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

8

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

9

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

10

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

11

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791- 802.

12

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-

13

13. Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697-704.

14

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

15

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

16

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

17

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

18

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

19

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

20

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

21

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

22

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

23

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

24

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

25

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

26

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

27

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

28

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

29

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

30

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

31

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

32

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1- 2):142-9.

33

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

34

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

35

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

36

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

37

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563- 77.

38

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

39

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

40

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

41

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

42

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

43

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

44

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

45

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

46

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

47

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

48

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

49

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

50

Noriki K, Shohei T, Masatoshi I, Osamu T, Izumi I, Takao S. DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups. Tetrahedron. 2014 Oct 28;70:43:8004-8009.

51

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

52

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: The next generation. Life Sci. 2014 Aug 15.

53

Kashiwagi T, Fuchigami T, Saito T, Nishiyama S, Atobe M. Sequential paired electrosynthesis of a diaryl ether derivative using an electrochemical microreactor. Chem Lett. 2014 Jun 5;43(6):799-801.

2013

2013年 全論文一覧

1

Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013; 13 (6): 881-7.

2

Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K. Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice. G3 (Bethesda). 2013; 3 (9): 1545-52.

3

Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; 7: 43.

4

Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y. COX-2-Derived PGE2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the EP3 Receptor. Circ Res. 2013. Jul 5; 113 (2): 104-14.

5

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. J. Comp. Neurol. 2013.

6

Takase K, Oda S, Kuroda M, Funato H. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PLoS One. 2013; 8 (3): e58473.

7

Suzuki A, Sinton CM, Greene RW, Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 2013; 110 (25): 10288-93.

8

Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis. Endocrinology. 2013; 154 (10): 3577-88.

9

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013; 4: 2883.

10

Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka T. Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab. 2013; 305 (11): E1415-25.

11

Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 2013; 4: 2563.

12

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T. Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice. PLoS One. 2013; 8 (7): e70012.

13

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. PLoS One. 2013; 8 (4): e62391.

14

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T. Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. J Neurosci. 2013; 33 (36): 14549-57.

15

Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M. κ Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Scientific Reports. 2013; 3: 3213.

16

Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H. The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists. Bioorg Med Chem. 2013; 21 (24): 7628-47.

17

Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013; 155 (6): 1323-36.