研究紹介論文一覧

Amezawa M, Yamamoto N, Nagumo Y, Kutsumura N, Ishikawa Y, Yanagisawa M, Nagase H, Saitoh T (2023) Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton. Bioorg. Med. Chem. Lett. 82129151. doi:10.1016/j.bmcl.2023.129151

Asano F, Kim SJ, Fujiyama T, Miyoshi C, Hotta-Hirashima N, Asama N, Iwasaki K, Kakizaki M, Mizuno S, Mieda M, Sugiyama F, Takahashi S, Shi S, Hirano A, Funato H, Yanagisawa M (2023) SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice. Proc. Natl. Acad. Sci. U.S.A. 120(11):e2218209120. doi:10.1073/pnas.2218209120

Chen C, Kawano T, Yanagisawa M, Hayashi Y (2023) Forward genetic screen of caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep. Genetics. 225(2). doi:10.1093/genetics/iyad140

Elhosainy A, Suzuki-Abe H, Kaushik MK, Kim SJ, Saitoh T, Ishikawa Y, Hotta-Hirashima N, Miyoshi C, Funato H, Yanagisawa M (2023) Face validation and pharmacologic analysis of Sik3Sleepy mutant mouse as a possible model of idiopathic hypersomnia. Eur. J. Pharmacol. 954175877. doi:10.1016/j.ejphar.2023.175877

Fan Z, Suzuki Y, Jiang L, Okabe S, Honda S, Endo J, Watanabe T, Abe T (2023) Peripheral blood flow estimated by laser doppler flowmetry provides additional information about sleep state beyond that provided by pulse rate variability. Front. Physiol. 141040425. doi:10.3389/fphys.2023.1040425

Fifel K, Yanagisawa M, Deboer T (2023) Mechanisms of sleep/wake regulation under hypodopaminergic state: Insights from MitoPark mouse model of parkinson’s disease. Adv. Sci. 10(5):doi:10.1002/advs.202203170

Guo H, Jiang J, Xu W, Zhang M, Chen H, Shi H, Wang L, He M, Lazarus M, Li S, Huang Z, Qu W (2023) Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice. Nat. Commun. 14(1):2346. doi:10.1038/s41467-023-37797-y

Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T (2023) Design and synthesis of orexin 1 receptor-selective agonists. J. Med. Chem. 66(8):5453-5464. doi:10.1021/acs.jmedchem.2c01773

Inoue M, Nakajima S, Inada N, Oi H, Sato N, Miyazaki Y, Takashina H, Tagaya H, Adachi Y, Kuga H (2023) Development of the parenting behavior checklist to promote preschoolers’ sleep (PCPP). Behav. Sleep Med. doi:10.1080/15402002.2023.2241590

Ishido H, Chiba S, Takahashi H, Isa M, Ogawa Y, Kubota H, Imanishi A, Omori Y, Ono T, Tsutsui K, Han G, Kondo H, Tsuji H, Nakamagoe K, Ishii A, Tanaka K, Tamaoka A, Shimizu T, Nishino S, Miyamoto T, Kanbayashi T (2023) Characteristics of hypersomnia due to inflammatory demyelinating diseases of the central nervous system. BMJ Neurol Open. 5(1):e000428. doi:10.1136/bmjno-2023-000428

Iwagami M, Seol J, Hiei T, Tani A, Chiba S, Kanbayashi T, Kondo H, Tanaka T, Yanagisawa M (2023) Association between electroencephalogram-based sleep characteristics and physical health in the general adult population. Sci Rep. 13(1):21545. doi:10.1038/s41598-023-47979-9

Kawaminami A, Yamada D, Yoshioka T, Hatakeyama A, Nishida M, Kajino K, Saitoh T, Nagase H, Saitoh A (2023) The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala. Neuropsychopharmacol. Rep. doi:10.1002/npr2.12406

Kawano T, Kashiwagi M, Kanuka M, Chen C, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y (2023) ER proteostasis regulators cell-non-autonomously control sleep. Cell Reports. 42(3):112267. doi:10.1016/j.celrep.2023.112267

Khalique V, Kitagawa H, Amagasa T (2023) BPF: A novel cluster boundary points detection method for static and streaming data. Knowl. Inf. Syst. 65(7):2991-3022. doi:10.1007/s10115-023-01854-1

Kobayashi R, Nakane S, Tomita J, Funato H, Yanagisawa M, Kume K (2023) A phosphorylation-deficient mutant of Sik3, a homolog of sleepy, alters circadian sleep regulation by PDF neurons in drosophila. Front. Neurosci. 171181555. doi:10.3389/fnins.2023.1181555

Korkutata M, Lazarus M (2023) Adenosine A2A receptors and sleep. Int. Rev. Neurobiol. 170155-178. doi:10.1016/bs.irn.2023.04.007

Koutsoumparis A, Busack I, Chen C, Hayashi Y, Braeckman BP, Meierhofer D, Bringmann H (2023) Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation. Genetics. 225(2). doi:10.1093/genetics/iyad124

Koyanagi I, Tezuka T, Yu J, Srinivasan S, Naoi T, Yasugaki S, Nakai A, Taniguchi S, Hayashi Y, Nakano Y, Sakaguchi M (2023) Fully automatic REM sleep stage-specific intervention systems using single EEG in mice. Neurosci. Res. 18651-58. doi:10.1016/j.neures.2022.10.001

Li R, Masuda K, Ono D, Kanbayashi T, Hirano A, Sakurai T (2023) Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice. Front. Neurosci. 171201137. doi:10.3389/fnins.2023.1201137

Lin Y, Roy K, Ioka S, Otani R, Amezawa M, Ishikawa Y, Cherasse Y, Kaushik MK, Klewe-Nebenius D, Zhou L, Yanagisawa M, Oishi Y, Saitoh T, Lazarus M (2023) Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front. Pharmacol. 141138666. doi:10.3389/fphar.2023.1138666

Luo Y, Ge J, Chen Z, Liu Z, Lazarus M, Qu W, Hang Z, Li Y (2023) Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections. iScience. 26(8):107385. doi:10.1016/j.isci.2023.107385

Maeda K, Ohrui S, Tokuda A, Nagumo Y, Yamamoto N, Tanimura R, Saitoh T, Kutsumura N, Nagase H (2023) Unexpected rearrangement reactions of the 14-aminonaltrexone skeleton. Org. Lett. 25(19):3407-3411. doi:10.1021/acs.orglett.3c00956

Martino P, Sunkara R, Heitman N, Rangl M, Brown A, Saxena N, Grisanti L, Kohan D, Yanagisawa M, Rendl M (2023) Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression. Nat. Cell Biol. 25(2):222-+. doi:10.1038/s41556-022-01065-w

Masuda K, Katsuda Y, Niwa Y, Sakurai T, Hirano A (2023) Analysis of circadian rhythm components in EEG/EMG data of aged mice. Front. Neurosci. 171173537. doi:10.3389/fnins.2023.1173537

Masuda K, Kon N, Iizuka K, Fukada Y, Sakurai T, Hirano A (2023) Singularity response reveals entrainment properties in mammalian circadian clock. Nat. Commun. 14(1):2819. doi:10.1038/s41467-023-38392-x

Mizuno Y, Uehara T, Nakamura Y, Okadome T, Mukaino T, Koh K, Takiyama Y, Kanbayashi T, Isobe N, Kira J, Murai H, Shigeto H (2023) A case of monozygotic twins with hereditary spastic paraplegia type 4 and epilepsy, of whom only one developed narcolepsy type 1. J. Sleep Res. doi:10.1111/jsr.14102

Monma T, Matsui T, Inoue K, Masuchi K, Okada T, Tamura M, Ishii T, Satoh M, Tokuyama K, Takeda F (2023) Prevalence and risk factors of poor subjective sleep quality in elite judo athletes. Sleep Biol. Rhythms. 21(3):289-297. doi:10.1007/s41105-023-00444-6

Moriya Y, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS, Uhl GR, Sora I (2023) Role for μ-opioid receptor in antidepressant effects of 8-opioid receptor agonist KNT-127. J. Pharmacol. Sci. 151(3):135-141. doi:10.1016/j.jphs.2022.12.008

Mukai Y, Okubo TS, Lazarus M, Ono D, Tanaka KF, Yamanaka A (2023) Prostaglandin E2 induces long-lasting inhibition of noradrenergic neurons in the locus coeruleus and moderates the behavioral response to stressors. J. Neurosci. 43(47):7982-7999. doi:10.1523/JNEUROSCI.0353-23.2023

Murakami Y, Yoshimura M, Klement WJ, Oda A, Sakamoto R, Yakabe M, Matsumoto A, Oketani R, Leproux P, Ikenouchi J, Browne WR, Kano H (2023) Backward multiplex coherent anti-stokes raman (CARS) spectroscopic imaging with electron CCD camera. Opt. Continuum. 2(9):2044-2054. doi:10.1364/OPTCON.497869

Nasu Y, Aggarwal A, Le GNT, Vo CT, Kambe Y, Wang X, Beinlich FRM, Lee AB, Ram TR, Wang F, Gorzo KA, Kamijo Y, Boisvert M, Nishinami S, Kawamura G, Ozawa T, Toda H, Gordon GR, Ge S, Hirase H, Nedergaard M, Paquet ME, Drobizhev M, Podgorski K, Campbell RE (2023) Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging. Nat. Commun. 14(1):6598. doi:10.1038/s41467-023-42230-5

Nishioka T, Attachaipanich S, Hamaguchi K, Lazarus M, d’Exaerde Ad’K, Macpherson T, Hikida T (2023) Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice. Nat. Commun. 14(1):2284. doi:10.1038/s41467-023-38025-3

Oda S, Funato H (2023) D1-and D2-type dopamine receptors are immunolocalized in pial and layer I astrocytes in the rat cerebral cortex. Front. Neuroanat. 171111008. doi:10.3389/fnana.2023.1111008

Okabe S, Abe T (2023) Subjectively intense odor does not affect dream emotions during rapid eye movement sleep. Sci Rep. 13(1):10442. doi:10.1038/s41598-023-37151-8

Ollila HM, et al. (2023) Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nat. Commun. 14(1):2709. doi:10.1038/s41467-023-36120-z

Ono Y, Ito R, Arai K, Singh G, Saitoh T, Russell RB, Raimondi F, Aoki J, Sakai J, Inoue A (2023) Chemogenetic activation of G12 signaling enhances adipose tissue browning. Signal Transduct. Target. Ther. 8(1):307. doi:10.1038/s41392-023-01524-2

Prokofeva K, Saito Y.C, Niwa Y, Mizuno S, Takahashi S, Hirano A, Sakurai T (2023) Structure and function of neuronal circuits linking ventrolateral preoptic nucleus and lateral hypothalamic area. J. Neurosci. 43(22):4075-4092. doi:10.1523/JNEUROSCI.1913-22.2023

Saitoh T, Sakurai T (2023) The present and future of synthetic orexin receptor agonists. Peptides. 167171051. doi:10.1016/j.peptides.2023.171051

Seol J, Kokudo C, Park I, Zhang S, Yajima K, Okura T, Tokuyama K (2023) Energy metabolism and thermoregulation during sleep in young and old females. Sci Rep. 13(1):10416. doi:10.1038/s41598-023-37407-3

Seol J, Lim N, Nagata K, Okura T (2023) Effects of home-based manual dexterity training on cognitive function among older adults: A randomized controlled trial. Eur. Rev. Aging Phys. Act. 20(1):9. doi:10.1186/s11556-023-00319-2

Takahashi TM, Sakurai T, Hirano A (2023) Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state. STAR Protoc. 4(2):102321. doi:10.1016/j.xpro.2023.102321

Takenawa S, Nagasawa Y, Go K, Cherasse Y, Mizuno S, Sano K, Ogawa S (2023) Activity of estrogen receptor β expressing neurons in the medial amygdala regulates preference toward receptive females in male mice. Proc. Natl. Acad. Sci. U.S.A. 120(42):e2305950120. doi:10.1073/pnas.2305950120

Tsuneoka Y, Nishikawa T, Furube E, Okamoto K, Yoshimura R, Funato H, Miyata S (2023) Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus. Neurosci. Lett. 814137463. doi:10.1016/j.neulet.2023.137463

Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y (2023) STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J. Exp. Med. 221(1):e20222178. doi:10.1084/jem.20222178

Yajima K, Chiba S, Park I, Ogata H, Kayaba M, Ishihara A, Tanaka Y, Simeng Z, Jaehoon S, Katakura M, Tokuyama K (2023) Dietary palmitic acid to oleic acid ratio modulates energy metabolism and biological rhythms in young healthy japanese males. Br.J.Nutr. doi:10.1017/S0007114523001770

Yamada M, Kitagawa H, Amagasa T, Matono A (2023) Augmented lineage: Traceability of data analysis including complex UDF processing. Vldb J. 32(5):963-983. doi:10.1007/s00778-022-00769-7

Yoshioka T, Yamada D, Segi-Nishida E, Nagase H, Saitoh A (2023) KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model. Neuropharmacology. 232109511. doi:10.1016/j.neuropharm.2023.109511

Yun R, Hong E, Kim J, Park B, Kim S J, Lee B, Song YS, Kim S, Park S, Kang JM (2023) N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer. Cell Death Dis. 14(8):546. doi:10.1038/s41419-023-06083-6

Miyanishi K, Hotta-Hirashima N, Miyoshi C, Hayakawa S, Kakizaki M, Kanno S, Ikkyu A, Funato H,Yanagisawa M. (2023) Microglia modulate sleep/wakefulness under baseline conditions and under acute social defeat stress in adult mice. Neurosci. Res. doi:10.1016/j.neures.2023.11.010

Kanda T, Aritake T, Ohyama K, Vogt KE, Makino Y, McHugh T, Hino H, Akaho S, Murata N (2023) Hawkes process modeling quantifies complicated firing behaviors of cortical neurons during sleep and wakefulness. bioRxiv. doi:10.1101/2023.07.29.550297

Díaz J, Ando H, Han G, Malyshevskaya O, Hayashi X, Letelier J, Yanagisawa M, Vogt KE (2023) Recovering arrhythmic EEG transients from their stochastic interference. arXiv. arXiv:2303.07683doi:arXiv:2303.07683 2023

Bou S, Amagasa T, Kitagawa H, Shaikh SA, Matono A (2023) Efficient missing value imputation by maximum distance likelihood. Proc. IEEE BigData 2023. 331-338. doi:10.1109/BigData59044.2023.10386584

Trisminingsih R, Shaikh SA, Amagasa T, Kitagawa H, Matono A (2023) Trapm: A framework for online pattern matching over trajectory streams. Proc. iiWAS 2023. 510-525. doi:10.1007/978-3-031-48316-5_45

Ohmori Y, Kitagawa H, Amagasa T, Matono A (2023) Integration of knowledge bases and external information sources via magic properties and query-driven entity linking. Proc. iiWAS 2023. 309-324. doi:10.1007/978-3-031-48316-5_30

Bou S, Kitagawa H, Amagasa T (2023) Cpix: Real-time analytics over out-of-order data streams by incremental sliding-window aggregation. Proc. ICDE 2023. 3759-3760. doi:10.1109/ICDE55515.2023.00310

Hasegawa E, Li Y, Sakurai T (2023) Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala. Neurosci. Res. S0168-0102(23):168. doi:10.1016/j.neures.2023.09.003

Ikeda Y, Morita E, Muroi K, Arai, Y, Ikeda, T, Takahashi T, Shiraki N, Doki S, Hori D, Oi Y, Sasahara S, Ishihara A, Matsumoto S, Yanagisawa M, Satoh M, Matsuzaki I (2022) Relationships between sleep efficiency and lifestyle evaluated by objective sleep assessment: Sleep Epidemiology Project at University of Tsukuba. Nagoya J. Med. Sci. 84(3):554-569. doi:10.18999/nagjms.84.3.554

Fifel K, Deboer T (2022) Heterogenous electrophysiological responses of functionally distinct striatal subregions to circadian and sleep-related homeostatic processes. Sleep 45(1). doi:10.1093/sleep/zsab230

Park I, Kokudo C, Seol J, Ishihara A, Zhang SM, Uchizawa A, Osumi H, Miyamoto R, Horie K, Suzuki C, Suzuki Y, Okura T, Diaz J, Vogt KE, Tokuyama K (2022) Instability of non-REM sleep in older women evaluated by sleep-stage transition and envelope analyses. Front. Aging Neurosci. 14. doi:10.3389/fnagi.2022.1050648

Hori D, Arai Y, Morita E, Ikeda Y, Muroi K, Ishitsuka M, Ikeda T, Takahashi T, Doki S, Oi Y, Sasahara S, Ishihara A, Matsumoto S, Kanbayashi T, Yanagisawa M, Satoh M (2022) Morning preference is associated with subjective happiness among Japanese female workers: A moderation analysis by sleep characteristics from the SLEPT study. Chronobiol. Int. 39(5):690-703. doi:10.1080/07420528.2022.2028801

Nemoto T, Irukayama-Tomobe Y, Hirose Y, Tanaka H, Takahashi G, Takahashi S, Yanagisawa M, Kanbayashi T (2022) Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide. J. Sleep Res. 31(5). doi:10.1002/advs.202203170

Fifel K, Yanagisawa M, Deboer T (2022) Mechanisms of sleep/wake regulation under hypodopaminergic state: Insights from MitoPark mouse model of Parkinson’s disease. Adv. Sci. 10(5). doi:10.1002/advs.202203170

Fujiyama T, Takenaka H, Asano F, Miyanishi K, Hotta-Hirashima N, Ishikawa Y, Kanno S, Seoane-Collazo P, Miwa H, Hoshino M, Yanagisawa M, Funato H (2022) Mice lacking cerebellar cortex and related structures show a decrease in slow-wave activity with normal non-REM sleep amount and sleep homeostasis. Front. Behav. Neurosci. 16. doi:10.3389/fnbeh.2022.910461

Fifel K, El Farissi A, Cherasse Y, Yanagisawa M (2022) Motivational and valence-related modulation of sleep/wake behavior are mediated by midbrain dopamine and uncoupled from the homeostatic and circadian processes. Adv. Sci. 9(24). doi:10.1002/advs.202200640

Han G, Matsumoto S, Diaz J, Greene RW, Vogt KE (2022) Dihydropyridine calcium blockers do not interfere with non-rapid eye movement sleep. Front. Neurosci. 16. doi:10.3389/fnins.2022.969712

Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato TA, Funato H, Yanagisawa M (2022) Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Neurosci. Res. 177:16-24. doi:10.1016/j.neures.2021.11.008

Bjorness TE, Greene RW (2022) Arousal-mediated sleep disturbance persists during cocaine abstinence in male mice. Front. Neurosci. 16. doi:10.3389/fnins.2022.868049

Xu JJ, Zhou R, Wang GD, Guo Y, Gao X, Zhou S, Ma CY, Chen L, Shi BH, Wang HY, Wang FC, Liu, Q (2022) Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinas5. Sleep 45(11). doi:10.1093/sleep/zsac198

Wang GD, Li Q, Xu JJ, Zhao S, Zhou R, Chen ZK, Jiang WT, Gao X, Zhou S, Chen ZY, Sun QZ, Ma CY, Chen L, Shi BH, Guo Y, Wang HY, Wang X, Li HY, Cai T, Wang YB, Chen ZN, Wang FC, Liu QH (2022) Somatic genetics analysis of sleep in adult mice. J. Neurosci. 42(28):5617-5640. doi:10.1523/JNEUROSCI.0089-22.2022

Adachi M, Nagaura Y, Eto H, Kondo H, Kato C (2022) The impact of sleep-wake problems on health-related quality of life among Japanese nursing college students: a cross sectional survey. Health Qual. Life Outcomes 20(1). doi:10.1186/s12955-022-02063-0

Miyazaki S, Kawano T, Yanagisawa M, Hayashi Y (2022) Intracellular Ca2+ dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans. iScience 25(6). doi:10.1016/j.isci.2022.104452

Hasegawa E, Miyasaka A, Sakurai K, Cherasse Y, Li YL, Sakurai T (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science 375(6584):994-1000. doi:10.1126/science.abl6618

Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T (2022) Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: A randomized, double-blind placebo-controlled study. Nutrients 14(4). doi:10.3390/nu14040755

Zhou R, Wang GD, Li Q, Meng FX, Liu C, Gan R, Ju DP, Liao MM, Xu JJ, Sang D, Gao X, Zhou S, Wu KJ, Sun QZ, Guo Y, Wu CY, Chen ZY, Chen L, Shi BH, Wang HY, Wang X, Li HY, Cai T, Li B, Wang FC, Funato H, Yanagisawa M, Zhang EE, Liu QH (2022) A signalling pathway for transcriptional regulation of sleep amount in mice. Nature 612(7940):519-527. doi:10.1038/s41586-022-05510-6

Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki, S, Tsuneoka, Y, Sugiyama, F, Takahashi, S, Hayashi, Y, Muratani, M, Liu, Q, Miyoshi, C, Yanagisawa M, Funato H (2022) Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature 612(7940):512-518. doi:10.1038/s41586-022-05450-1

Chen ZK, Dong H, Liu CW, Liu WY, Zhao YN, Xu W, Sun X, Xiong YY, Liu YY, Yuan XS, Wang B, Lazarus M, Cherasse Y, Li YD, Han F, Qu WM, Ding FF, Huang ZL (2022) A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discov. 8(1):115. doi:10.1038/s41421-022-00456-5

Tone D, Ode KL, Zhang QH, Fujishima H, Yamada RG, Nagashima Y, Matsumoto K, Wen ZQ, Yoshida SY, Mitani TT, Arisato Y, Ohno R, Ukai-Tadenuma M, Garcon JY, Kaneko M, Shi, S, Ukai H, Miyamichi K, Okada T, Sumiyama K, Kiyonari H, Ueda HR (2022) Distinct phosphorylation states of mammalian CaMKII beta control the induction and maintenance of sleep. PLoS. Biol. 20(10). doi:10.1371/journal.pbio.3001813

Uemura SI, Imanishi A, Terui Y, Park I, Satake M, Han G, Shioya T, Kanbayashi T, Nishino S (2022) Residual effects of low dose of suvorexant, zolpidem, and ramelteon in healthy elderly subjects: A randomized double-blind study. Neuropsychopharmacol. Rep. 42(3):288-298. doi:10.1002/npr2.12262

Ogawa T, Kajiyama Y, Ishido H, Chiba S, Revankar GS, Nakano T, Taniguchi S, Kanbayashi T, Ikenaka K, Mochizuki H (2022) Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson’s disease: A retrospective study. PLoS One 17(12). doi:10.1371/journal.pone.0279747

Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M (2022) OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy. PLoS One 17(7). doi:10.1371/journal.pone.0271901

Korkutata M, Agrawal L, Lazarus M (2022) Allosteric modulation of adenosine A(2A) receptors as a new therapeutic avenue. Int. J. Mol. Sci. 23(4):128-130. doi:10.3390/ijms23042101

Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H, Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y, Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T, Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of idiopathic hypersomnia in a Japanese population. Sleep Biol. Rhythms 20(1):137-148. doi:10.1007/s41105-021-00349-2

Choi YJ, Nakamura Y, Akazawa N, Park, I, Kwak HB, Tokuyama K, Maeda S (2022) Effects of nocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover trial. Chronobiol. Int. 39(4):602-612. doi:10.1080/07420528.2021.2014517

Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T (2022) Optogenetic induction of hibernation-like state with modified human Opsin4 in mice. Cell Reports Methods 2(11). doi:10.1016/j.crmeth.2022.100336

Nagayama M, Aritake T, Hino H, Kanda T, Miyazaki T, Yanagisawa M, Akah, S, Murata N (2022) Detecting cell assemblies by NMF-based clustering from calcium imaging data. Neural Netw. 149:29-39. doi:10.1016/j.neunet.2022.01.023

Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yangisawa M, Nagase H (2022) Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatri-quinane bearing multiple effective residues (TriMER) library. Eur. J. Med. Chem. 240. doi:10.1016/j.ejmech.2022.114505

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Ishihara A, Park I, Suzuki Y, Yajima K, Cui H, Yanagisawa M, Sano T, Kido J, Tokuyama K (2021) Metabolic responses to polychromatic LED and OLED light at night. Scientific reports 11(1). doi:10.1038/s41598-021-91828-6

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Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M (2016) Peripherally administered orexin improves survival of mice with endotoxin shock. eLife 5: e21055. doi:10.7554/eLife.21055

Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M (2016) Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS One 11(7): e0159246. doi:10.1371/journal.pone.0159246

Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F (2016) Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice. Exp. Anim. 65 (3): 319-327. doi:10.1538/expainm.16-0016

Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F (2016) Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54(7): 389-397. doi:10.1002/dvg.22944

Tran MTN, Hamada M, Nakamura M, Jeon H, Kamei R, Tsunakawa Y, Kulathunga K, Lin YY, Fujisawa K, Kudo T, Takahashi S (2016) MafB deficiency accelerates the development of obesity in mice. FEBS Open Bio 6(6): 540-547. doi:10.1002/2211-5463.12058

Daassi D, Hamada M, Jeon H, Imamura Y, Tran MTN, Takahashi S (2016) Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem. Biophys. Res. Commun. 473(1): 118-124. doi:10.1016/j.bbrc.2016.03.063

Jeon H, Waku T, Azami T, Khoa LTP, Yanagisawa J, Takahashi S, Ema M (2016) Comprehensive Identification of Kruppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming. PLoS One 11(3): e0150715. doi:10.1371/journal.pone.0150715

Abdellatif’ AM, Oishi H, Itagaki T, Jung YS, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S (2016) beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One 11(2): e0150010. doi:10.1371/journal.pone.0150010

Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N (2016) Overexpression of ROR gamma t Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. PLoS One 11(1): e0147064. doi:10.1371/journal.pone.0147064

Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, Murata T (2016) Prostaglandin D-2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One 11(12): e0167729. doi:10.1371/journal.pone.0167729

Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A(2A) receptors. J. Sleep Res. 25(6): 746-753. doi:10.1111/jsr.12434

Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial. J. Sleep Res. 25(1): 116-123. doi:10.1111/jsr.12336

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat. Commun. 7: 11613. doi:10.1038/ncomms11613

Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS (2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 311(2): R263-R271. doi:10.1152/ajpregu.00016.2015

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight 1(11): e87860. doi:10.1172/jci.insight.87680

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A (2016) Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res. Ther. 18(1): 113. doi:10.1186/s13075-016-1011-4

Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM (2016) Functional ETA-ETB Receptor Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats. J. Cardiovasc. Pharmacol. 67(3): 212-217. doi:10.1097/FJC.0000000000000335

Kutsumura N, Numata K, Saito T (2016) First total synthesis of haplacutine C. Tetrahedron Lett. 57(50): 5581-5583. doi:10.1016/j.tetlet.2016.10.070

Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG (2016) A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol. 11(12): 3383-3390. doi:10.1021/acschembio.6b00727

Ioka S, Saitoh T, Maki SA, Imoto M, Nishiyama S (2016) Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization. Tetrahedron 72(47): 7505-7508. doi:10.1016/j.tet.2016.09.069

Honda T, Lee CY, Honjo K, Furukubo-Tokunaga K (2016) Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae. Front. Behav. Neurosci. 10: 137. doi:10.3339/fnbeh.2016.00137

Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S (2016) Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties. Chem.-Eur. J. 22(27): 9330-9337. doi:10.1002/chem.201600278

Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J (2016) OPIOID SYSTEMS IN THE LATERAL HYPOTHALAMUS REGULATE FEEDING BEHAVIOR THROUGH OREXIN AND GABA NEURONS. Neuroscience 320(183): 193 doi: 10.1016/j.neuroscience.2016.02.002

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791- 802.

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-

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Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1- 2):142-9.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563- 77.

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

Noriki K, Shohei T, Masatoshi I, Osamu T, Izumi I, Takao S. DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups. Tetrahedron. 2014 Oct 28;70:43:8004-8009.

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: The next generation. Life Sci. 2014 Aug 15.

Kashiwagi T, Fuchigami T, Saito T, Nishiyama S, Atobe M. Sequential paired electrosynthesis of a diaryl ether derivative using an electrochemical microreactor. Chem Lett. 2014 Jun 5;43(6):799-801.

Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013; 13 (6): 881-7.

Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K. Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice. G3 (Bethesda). 2013; 3 (9): 1545-52.

Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; 7: 43.

Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y. COX-2-Derived PGE2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the EP3 Receptor. Circ Res. 2013. Jul 5; 113 (2): 104-14.

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. J. Comp. Neurol. 2013.

Takase K, Oda S, Kuroda M, Funato H. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PLoS One. 2013; 8 (3): e58473.

Suzuki A, Sinton CM, Greene RW, Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 2013; 110 (25): 10288-93.

Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis. Endocrinology. 2013; 154 (10): 3577-88.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013; 4: 2883.

Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka T. Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab. 2013; 305 (11): E1415-25.

Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 2013; 4: 2563.

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T. Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice. PLoS One. 2013; 8 (7): e70012.

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. PLoS One. 2013; 8 (4): e62391.

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T. Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. J Neurosci. 2013; 33 (36): 14549-57.

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