Robert Greene

Affiliation:International Institute for Integrative Sleep Medicine, University of Tsukuba University of Texas Southwestern Medical Center

Research Title


Sleep and sleep regulation - understanding cortical slow waves.

01 Research Summary

Missing sleep for even a few hours is unpleasant and normal mental tasks, such as driving, become more and more difficult. Luckily, sleep, especially deep, slow wave sleep will restore the brain's ability to function. During slow wave sleep neurons in the cortex alternate between silent OFF states and active ON states in a highly synchronous manner - giving rise to characteristic waves in the electro-encephalogram (EEG). The activity during the ON states resembles waking, but we are now finding important differences between wake activity and the activity patterns observed in sleep. We want to characterize the activity of neurons and of neural networks during slow wave sleep to understand the function of this specific activity pattern and its regulation.

UT Southwestern

02 Major achievements

Locus coeruleus and dopaminergic consolidation of everyday memory. Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M, Smith CC, Fernández G, Deisseroth K, Greene RW, Morris RG. Nature. 2016 Sep 15;537(7620):357-362. doi: 10.1038/nature19325. Epub 2016 Sep 7

An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep. Bjorness TE, Dale N, Mettlach G, Sonneborn A, Sahin B, Fienberg AA, Yanagisawa M, Bibb JA, Greene RW. J Neurosci. 2016 Mar 30;36(13):3709-21. doi: 10.1523/JNEUROSCI.3906-15.2016

Diversity in GABAergic signaling. Vogt K. Adv Pharmacol. 2015;73:203-22. doi: 10.1016/bs.apha.2014.11.009. Epub 2015 Jan 14.

03 Education/Academic background

I received a B.A. from Kenyon College, Gambier, Ohio in 1972 and a PhD. from George Washington University, School of Arts and Science, Washington, 1982.In 1983 I obtained an MD. from the University of Maryland School of Medicine.

I held a postdoctoral research position in neurophysiology and -pharmacology from 1983 to 1984 at the University of Maryland. from 1984 to 1985 I was a Fogarty and Swiss National Science Foundation fellow at the Department of Neurosurgery at the University Hospital in Zurich. From 1989 to 1995 I was a resident in the psychiatry department at Harvard Medical School and the Brockton/West Roxbury VAMC. From 1990 to 2001 I was an Assistant and then Associate Professor for Psychiatry at the Department of Psychiatry at Harvard medical School. In became a tenured Professor for Psychiatry at University of Texas Southwestern (UTSW) in 2001. Beginning in 2012 I became a Visiting scientist at the Department of Molecular Pharmacology, Physiology and Biotechnology (MPPB) at Brown University and from 2014 at IIIS.


Why did you become a scientist?

It is fun and highly rewarding.

Science presents you with new challenges every day. You can ask new questions and solve new problems and enjoy the learning more about nature.

What are you most interested in lately


Sailing also allows you to be in a dialog with nature. You need to understand the wind and the sea and the boat to get where you want to go. I sail on the ocean and enjoy its wide open expanse. Currently I sail on a classic wooden boat that was designed close to where I come from.