Shoi Shi

Affiliation:International Institute for Integrative Sleep Medicine, University of Tsukuba

Research Title

Data Science

Comparative neuroscience untangles the Conservation and Diversity of Sleep

01 Research Summary

Sleep is a physiological phenomenon that is widely conserved in organisms. To understand the mechanisms and functions of this genetically conserved phenomenon and to question its evolutionary significance, it is essential to make comparisons among species. In particular, from the perspective of the evolution of organisms, it is undeniable that the neural structures of a species are constrained by its unique properties. In other words, by quantitatively comparing multiple species, it is possible to broadly distinguish between species-specific properties and properties common to all organisms, and to extract the smallest structural and functional unit of commonality among organisms. Our laboratory aims to extract the molecular and neuroscientific minimum units common to sleep-wake cycles by using mice as vertebrates and ants as social arthropods with in collaboration with other non-model animal researchers.

02 Major achievement

*Katori M, *Shi S, Ode KL, Tomita Y, Ueda HR. (*Equally contributed) 103,200 acceleration data in UK Biobank revealed a landscape of human sleep phenotypes. Proc. Natl. Acad. Sci. U.S.A. in press

*Yamada T, *Shi S, Ueda HR. (*Equally contributed) A Design principle of Spindle Oscillations in Mammalian Sleep. iScience 25(3), 103873 (2022)

Shi S, Tanaka S, Ueno R, Gilmour S, Tanoue Y, Kawashima T, Nomura S, Miyata H, Yoneoka D. Impact of travel restrictions on importation of novel coronavirus infection: An effective distance approach. Bull World Health Organ. 98, 518-529 (2020)

*Yoshida K, *Shi S, Ukai-Tadenuma M, Fujishima H, Ohno RI, and Ueda HR. (*Equally contributed) Leak potassium channels regulate sleep duration. Proc. Natl. Acad. Sci. U.S.A. 115 (40), E9459-E9468 (2018)

*Tatsuki F, *Sunagawa GA, *Shi S, *Susaki EA, *Yukinaga H, *Perrin D, Sumiyama K, Ukai-Tadenuma M, Fujishima H, Ohno RI, Tone D, Ode KL, Matsumoto K, Ueda HR. (*Equally contributed) Involvement of Ca2+ - Dependent Hyperpolarization in Sleep Duration in Mammals. Neuron. 90, 70-85 (2016)

03 Education/Academic background and major awards

Education/Academic background

2017 Ph.D. in Medicine (The University of Tokyo)
2017 - 2022 Assistant Professor, School of Medicine, The University of Tokyo
2017 - Visiting Researcher, RIKEN Center for Biosystems Dynamics Research
2020 - 2022 Project Researcher, School of Medicine, Keio University
2020 - 2022 ERATO UEDA Biological Timing Project Human Sleep Group GL
2022 - Visiting Researcher, School of Medicine, The University of Tokyo
2022 - Principal Investigator, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba

Q&A Q&A

Why did you become a scientist?

Love and enjoy science

The first time I thought of becoming a researcher was when I was in high school. I really liked to think about the mechanisms and significance of many phenomena in nature. Life in nature is so profound and diverse that it is difficult for a single mind to come up with the correct answer. And even when I finally come up with an idea, sometimes someone else has already thought of it, but even so, it is a wonderful challenge to experiment, analyze, and look at the data every day and think of new ideas.

What are the characteristics of your lab?

Comparative neuroscience proceeding with both questions and technological development

As a researcher, I believe it is very important to have one's own questions about biological phenomena. On the other hand, technological advancements often provide a landscape of our world and shape new ways to understand it. Therefore, our laboratory will develop a technology to quantitatively compare between species, which will serve as driving force for comparative neuroscience and understanding fundamental biological phenomenon (e.g., sleep). We will use not only neuroscientific methods, but also genetics, computational science, and various other techniques to advance our research. Researchers from any background are welcome. If you are interested in the phenomenon of sleep, in the development of technologies for comparative neuroscience, or have your own interesting questions, not limited to sleep, please contact us.

What are you most interested in lately

Running and exercise

During my school days, I enjoyed many hobbies such as bouldering, martial arts, watching movies, and visiting museums, but recently I have not been able to find the time for them. I run from Tsukuba station to the laboratory every day and do some exercise in the PI room.