ResearchResearch Articles

Suzuki Y, Kawana F, Satoh M, Abe T (2021) The abrupt shift to slower frequencies after arousal from sleep in healthy young adults. Journal of Clinical Sleep Medicine 17(12): 2373-2381. doi:10.5664/jcsm.9434

Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato TA, Sakaguchi M (2021) Metabolic fingerprints of fear memory consolidation during sleep. Molecular Brain 14(1). doi:10.1186/s13041-021-00733-6

Iwasaki K, Fujiyama T, Nakata S, Park M, Miyoshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M, Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M (2021) Induction of mutant Sik3(Sleepy) allele in neurons in late infancy increases sleep need. Journal of Neuroscience 41(12): 2733-2746. doi:10.1523/JNEUROSCI.1004-20.2020

Choi J, Kim SJ, Fujiyama T, Miyoshi C, Park M, Suzuki-Abe H, Yanagisawa M, Funato H (2021) The role of reproductive hormones in sex differences in sleep homeostasis and arousal response in mice. Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.739236

Kashiwagi M, Kanuka M, Tanaka K, Fujita M, Nakai A, Tatsuzawa C, Kobayashi K, Ikeda K, Hayashi Y (2021) Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice. Molecular Brain 14(1). doi:10.1186/s13041-021-00879-3

Gao TX, Li JY, Watanabe Y, Hung CJ, Yamanaka A, Horie K, Yanagisawa M, Ohsawa M, Kume K (2021) GI-SleepNet: A highly versatile image-based sleep classification using a deep learning algorithm. Clocks & Sleep 3(4): 581-597. doi:10.3390/clockssleep3040041

Zhang SM, Tanaka Y, Ishihara A, Uchizawa A, Park I, Iwayama K, Ogata H, Yajima K, Omi N, Satoh M, Yanagisawa M, Sagayama H, Tokuyama K (2021) Metabolic flexibility during sleep. Scientific Reports 11(1). doi:10.1038/s41598-021-97301-8

Uchida S, Soya S, Saito YC, Hirano A, Koga K, Tsuda M, Abe M, Sakimura K, Sakurai T (2021) A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice. Journal of Neuroscience 41(7): 1582-1596. doi:10.1523/JNEUROSCI.0688-20.2020

Tezuka T, Kumar D, Singh S, Koyanagi I, Naoi T, Sakaguchi M (2021) Real-time, automatic, open-source sleep stage classification system using single EEG for mice. Scientific Reports 11(1). doi:10.1038/s41598-021-90332-1

Liu CY, Tsai CJ, Yasugaki S, Nagata N, Morita M, Isotani A, Yanagisawa M, Hayashi Y (2021) Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice. Neuroscience Research 14-25. doi:10.1016/j.neures.2020.04.002

Park I, Diaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh M, Tokuyama K, Vogt KE (2021) Exercise improves the quality of slow-wave sleep by increasing slow-wave stability. Scientific reports 11(1). doi:10.1038/s41598-021-83817-6

Kaushik MK, Aritake K, Cherasse Y, Imanishi A, Kanbayashi T, Urade Y, Yanagisawa M (2021) Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice. Sleep 44(8). doi:10.1093/sleep/zsab043

Uchizawa A, Hibi M, Sagayama H, Zhang SM, Osumi H, Tanaka Y, Park I, Tokuyama K, Omi N (2021) Novel equations to estimate resting energy expenditure during sitting and sleeping. Annals of Nutrition and Metabolism 77(3): 159-167. doi:10.1159/000516174

Seol J, Park I, Kokudo C, Zhang SM, Suzuki C, Yajima K, Satoh M, Tokuyama K, Okura T (2021) Distinct effects of low-intensity physical activity in the evening on sleep quality in older women: A comparison of exercise and housework. Experimental Gerontology 143. doi:10.1016/j.exger.2020.111165

Suzuki F, Morita E, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kannon T, Tajima A, Matsumoto S, Ishihara A, Hori D, Doki S, Oi Y, Sasahara S, Satoh M, Matsuzaki I, Yanagisawa M, Ikaga T, Nakamura H (2021) Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study. PLOS ONE 16(2). doi:10.1371/journal.pone.0247926

Seol J, Lee J, Nagata K, Fujii Y, Joho K, Tateoka K, Inoue T, Liu J, Okura T (2021) Combined effect of daily physical activity and social relationships on sleep disorder among older adults: cross-sectional and longitudinal study based on data from the Kasama study. BMC Geriatrics 21(1). doi:10.1186/s12877-021-02589-w

Yang YF, Dong H, Shen Y, Li L, Lazarus M, Qu WM, Huang ZL (2021) Mesencephalic dopamine neurons are essential for modafinil-induced arousal. British Journal of Pharmacology 178(24): 4808-4825. doi:10.1111/bph.15660

Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H, Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y, Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T, Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of idiopathic hypersomnia in a Japanese population. Sleep and Biological Rhythms 20(1): 137-148. doi:10.1007/s41105-021-00349-2

Kaneko Y, Inoue Y, Fujiki N, Han G, Nishino S, Shimizu T, Kanbayashi T, Kondo H (2021) The anticataplectic and REM suppression effect of milnacipran, an SNRI, on human and canine narcolepsy. Sleep and Biological Rhythms 19(2): 137-143. doi:10.1007/s41105-020-00298-2

Ishihara A, Park I, Suzuki Y, Yajima K, Cui H, Yanagisawa M, Sano T, Kido J, Tokuyama K (2021) Metabolic responses to polychromatic LED and OLED light at night. Scientific reports 11(1). doi:10.1038/s41598-021-91828-6

Saito R, Miyoshi C, Koebis M, Kushima I, Nakao K, Mori D, Ozaki N, Funato H, Yanagisawa M, Aiba A (2021) Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. Molecular Brain 14(1). doi:10.1186/s13041-021-00778-7

Choi YJ, Nakamura Y, Akazawa N, Park I, Kwak HB, Tokuyama K, Maeda S (2022) Effects of nocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover trial. Chronobiology International 39(4): 602-612. doi:10.1080/07420528.2021.2014517

Vergara P, Kumar D, Srinivasan S, Koyanagi I, Naoi T, Singh S, Sakaguchi M (2021) Remapping of adult-born neuron activity during fear memory consolidation in mice. International Journal of Molecular Sciences 22(6). doi:10.3390/ijms22062874

Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL (2021) Medial parabrachial nucleus is essential in controlling wakefulness in rats. Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.645877

Inagawa Y, Shimizu S, Takenoshita n, Tsugawa A, Hirose D, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H, Kanetaka H, Hirao K (2021) Association between cerebrospinal fluid Orexin A level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies. Psychogeriatrics 21(1): 128-130. doi:10.1111/psyg.12618

Li YD, Luo YJ, Xu W, Ge J, Cherasse Y, Wang YQ, Lazarus M, Qu WM, Huang ZL (2021) Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Molecular Psychiatry 26(7): 2912-2928. doi:10.1038/s41380-020-00906-0

Miyanishi K, Sato A, Kihara N, Utsunomiya R, Tanaka J (2021) Synaptic elimination by microglia and disturbed higher brain functions. Neurochemistry International 142. doi:10.1016/j.neuint.2020.104901

Yu JH, Naoi T, Sakaguchi M (2021) Fear generalization immediately after contextual fear memory consolidation in mice. Biochemical and Biophysical Research Communications 102-106. doi:10.1016/j.bbrc.2021.04.072

Tanaka Y, Ogata H, Park I, Ando A, Ishihara A, Kayaba M, Yajima K, Suzuki C, Araki A, Osumi H, Zhang SM, Seol J, Takahashi K, Nabekura Y, Satoh M, Tokuyama K (2021) Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men. Physiological Reports 9(7). doi:10.14814/phy2.14784

Liu C, Lee CY, Asher G, Cao LQ, Terakoshi Y, Cao P, Kobayakawa R, Kobayakawa K, Sakurai K, Liu QH (2021) Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice. Nature Communications 12(1). doi:10.1038/s41467-021-22914-6

Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii KA, Tanaka T, Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T (2022) Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes. Journal of Diabetes Investigation 13(3): 532-542. doi:10.1111/jdi.13699

Yamamoto T, Saitoh T, Einaga Y, Nishiyama S (2021) Anodic oxidation of phenols: A key step for the synthesis of natural products. Chemical Record 21(9): 2254-2268. doi:10.1002/tcr.202100032

Noorani SK, Hojati V, Akbari E, Ehsani S, Sakurai T, Ardeshiri MR (2021) The role of interaction between orexin receptors and beta 2 adrenergic receptors in basolateral amygdala in dentate gyrus synaptic plasticity in male rats. Brain Research Bulletin 164-171. doi:10.1016/j.brainresbull.2021.09.020

Maejima T, Tsuno Y, Miyazaki S, Tsuneoka Y, Hasegawa E, Islam MT, Enoki R, Nakamura TJ, Mieda M (2021) GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior. PNAS 118(6). doi:10.1073/pnas.2010168118

Yamada D, Takahashi J, Iio K, Nagase H, Saitoh A (2021) Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice. Biochemical and Biophysical Research Communications 192-198. doi:10.1016/j.bbrc.2021.05.002

Bittar TP, Pelaez MC, Silva JCH, Quessy F, Lavigne AA, Morency D, Blanchette LJ, Arsenault E, Cherasse Y, Seigneur J, Timofeev I, Sephton CF, Proulx CD, Labonte B (2021) Chronic stress induces sex-specific functional and morphological alterations in corticoaccumbal and corticotegmental pathways. Biological Psychiatry 90(3): 194-205. doi:10.1016/j.biopsych.2021.02.014

Sakamoto K, Yamada D, Yamanaka N, Nishida M, Iio K, Nagase H, Saitoh A (2021) A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. Brain Research 1757. doi:10.1016/j.brainres.2021.147297

Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJM (2021) Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. PNAS 118(12). doi:10.1073/pnas.2005753118

Matsuo T, Isosaka T, Hayashi Y, Tang LJ, Doi A, Yasuda A, Hayashi M, Lee CY, Cao LQ, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu QH, Kobayakawa R, Kobayakawa K (2021) Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nature Communications 12(1). doi:10.1038/s41467-021-22205-0

Nagata K, Nagase H, Okuzumi A, Nishiyama C (2021) Delta opioid receptor agonists ameliorate colonic inflammation by modulating immune responses. Frontiers in Immunology 12. doi:10.3389/fimmu.2021.730706

Ohrui S, Irukayama-Tomobe Y, Ishikawa Y, Yanagisawa M, Nagase H (2021) Design and synthesis of novel orexin antagonists via structural simplification of the morphinan skeleton. Heterocycles 103(2): 929-951. doi:10.3987/COM-20-S(K)63

Hino T, Kutsumura N, Saitoh T, Yamamoto N, Nagumo Y, Mogi Y, Watanabe Y, Nagase H (2021) Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives. Tetrahedron Letters 63. doi:10.1016/j.tetlet.2020.152714

Yu LY, Tseng TJ, Lin HC, Hsu CL, Lu TX, Tsai CJ, Lin YC, Chu I, Peng CT, Chen HJ, Tsai FC (2021) Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration. Science Advances 7(31). doi:10.1126/sciadv.abg2106

Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N (2022) Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis. Psychopharmacology 239(2): 525-531. doi:10.1007/s00213-021-06036-x

Nakagawa Y, Wang YN, Han S, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H (2021) Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition. Cellular and Molecular Gastroenterology and Hepatology 11(4): 949-971. doi:10.1016/j.jcmgh.2020.11.004

Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A, Nakagawa Y, Shimano H, Higami Y (2021) Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle. Experimental gerontology 154. doi:10.1016/j.exger.2021.111519

Ryanto GRT, Ikeda K, Miyagawa K, Tu L, Guignabert C, Humbert M, Fujiyama T, Yanagisawa M, Hirata K, Emoto N (2021) An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension. Nature communications 12(1). doi:10.1038/s41467-021-21961-3

Shimamoto S, Nakagawa Y, Hidaka Y, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, Ohkubo T, Aritake K, Kaushik MK, Urade Y (2021) Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase. Biochemical and biophysical research communications 66-71. doi:10.1016/j.bbrc.2021.06.092

Omoya R, Miyajima M, Ohta K, Suzuki Y, Aoki A, Fujiwara M, Watanabe T, Yoshida N, Suwa H, Kawara T, Takahashi H, Matsushima E, Takeuchi T (2021) Heart rate response to orthostatic challenge in patients with dementia with Lewy bodies and Alzheimer’s disease. Psychogeriatrics 21(1): 62-70. doi:10.1111/psyg.12625

Murata K, Mimura A, Suzuki H, Mikami N, Hamada Y, Kato K, Iki N, Ishida M, Daitoku Y, Tanimoto Y, Okiyoneda T, Fujiyama T, Dinh TTH, Mizuno S, Sugiyama F (2021) Efficient induction of proximity-dependent labelling by biotin feeding in BMAL1-BioID knock-in mice. Journal of Biochemistry 170(4): 453-461. doi:10.1093/jb/mvab059

Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H (2021) Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB Journal 35(6). doi:10.1096/fj.202002784RR

Shokirova H, Inomata T, Saitoh T, Zhu J, Fujio K, Okumura Y, Yanagawa A, Fujimoto K, Sung J, Eguchi A, Miura M, Nagino K, Hirosawa K, Kuwahara M, Akasaki Y, Nagase H, Murakami A (2021) Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation. Scientific Reports 11(1). doi:10.1038/s41598-021-88118-6

Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami K, Wilson V, Arkell RM, Sugiyama F (2021) Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Elife 10. doi:10.7554/eLife.50346

Takei Y, Hirai R, Fukuda A, Miyazaki S, Shimada R, Okamatsu-Ogura Y, Saito M, Leproux P, Hisatake K, Kano H (2021) Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator. Journal of Chemical Physics 155(12). doi:10.1063/5.0063250

Aso T, Amagasa T, Kitagawa H (2021) A system for relation-oriented faceted search over knowledge bases. International Journal of Web Information Systems 17(6) 698-713. doi:10.1108/IJWIS-03-2021-0035

Takagi H, Chen H, Furuse K, Kitagawa H (2021) Aggregate nearest neighborhood queries. Proc. FICC 2021. Advances in Intelligent Systems and Computing 1364 396–414. doi:10.1007/978-3-030-73103-8_28

Kato Y, Chen H, Furuse K, Kitagawa H (2021) Unifying spatial keyword indexing in continuous search on dynamic objects. Proc. FICC 2021. Advances in Intelligent Systems and Computing 1364 415–430. doi:10.1007/978-3-030-73103-8_29

Khalique V, Kitagawa H (2021) VOA*: Fast angle-based outlier detection over high-dimensional data streams. Proc. PAKDD 2021. Lecture Notes in Computer Science 12712 44-52. doi:10.1007/978-3-030-75762-5_4

Yoshimura C, Kitagawa H (2021) TLV-Bandit: Bandit method for collecting topic-related local tweets. Proc. 2021. IEEE 4th International Conference on Multimedia Information Processing and Retrieval (MIPR) 56-62. doi:1109/MIPR51284.2021.00016

Yamada M, Kitagawa H, Amagasa T, Matono A (2021) Augmented lineage: Traceability of data analysis including complex UDFs. Proc. DEXA 2021. Lecture Notes in Computer Science 12923 65–77. doi:10.1007/978-3-030-86472-9_6

Aso T, Amagasa T, Kitagawa H (2021) A method for searching documents using knowledge bases. Proc. iiWAS2021 250-258. doi:10.1145/3487664.3487699

Carrier-Ruiz A, Sugaya Y, Kumar D, Vergara P, Koyanagi I, Srinivasan S, Naoi T, Kano M, Sakaguchi M (2021) Calcium imaging of adult-born neurons in freely moving mice, STAR Protocols 2(1):100328, 2021Mar19. doi/10.1016/j.xpro.2020.100238

Tsai CJ, Nagata T, Liu CY, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M, Vogt V, Yanagisawa M, Hayashi Y (2021) Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. Cell Reports 36(7). doi:10.1016/j.celrep.2021.109558

Sakamoto K, Morikuni K, Sakurai T, Matsumoto S, Vogt K (2021) Online spectral classification for long-term spike sorting. 2021 5th International Conference on Medical and Health Informatics Pages 89-97

Park I, Díaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh M, Tokuyama K, Vogt K (2021) Exercise improves the quality of slow-wave sleep by increasing slow-wave stability. Scientific Reports 11(1). doi:10.1038/s41598-021-83817-6

Park I, Suzuki C, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Kokubo T, Tokuyama K, Yanagisawa M, Satoh M (2021) Effects of body pillow use on sleeping posture and sleep architecture in healthy young adults. Sleep Medicine Research 12(1): 57-63.

Ikeda T, Hori D, Arai Y, Muroi K, Ikeda Y, Takahashi K, Shiraki N, Doki S, Oi Y, Sasahara S, Morita E, Matsuzaki I (2021) Association between forest and greenspace walking and stress-coping skills among workers of Tsukuba Science City, Japan: a cross-sectional study. Public Health in Practice. 2021; 2: 100074

Sakurai T, Saito Y, Yanagisawa M (2021) Interaction between orexin neuronsand monoaminergic systems. Front Neurol Neurosci 45 11-21. doi:10.1159/000514955

Suzuki Y, Abe T, Kawana F, Okabe S, Kokubo T, Hoshino K, Baba M, Fujiyama M, Yanagisawa M (2021) O-EG004.Comparing the accuracy of sleep staging data from a new wearable sleep electroencephalography device versus the Fitbit Charge 3 with polysomnography as reference. Clinical Neurophysiology 132(8): 67. doi:10.1016/j.clinph.2021.02.125

Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato T, Funato H, Yanagisawa M (2021) Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Journal of Neuroscience Research 177 16-24. doi:10.1016/j.neures.2021.11.008

Iwasaki K, Hotta-Hirashima N, Funato H, Yanagisawa M (2021) Protocol for sleep analysis in the brain of genetically modified adult mice. STAR Protocols 2(4): 100982. doi: 10.106/j.xpro.2021.100982

Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H (2021) Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. Biomedical Optics Express 13(2): 694-708. doi: 10.1364/BOE.446273

Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H (2021) Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondria disease. Cell Metabolism 33:1974-1987

Abe T, Mishima K, Kitamura S, Hida A, Inoue Y, Mizuno K, Kaida K, Nakazaki K, Motomura Y, Maruo K, Ohta T, Furukawa S, Dinges DF, Ogata K (2020) Tracking intermediate performance of vigilant attention using multiple eye metrics. Sleep 43(3). Doi:10.1093/sleep/zsz219

Bjorness TE, Greene RW (2020) Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an orexin Receptor-Modulated Manner. Eneuro 7(6). Doi:10.1523/ENEURO.0283-20.2020

Bjorness TE, Kulkarni A, Rybalchenko V, Suzuki A, Bridges C, Harrington AJ, Cowan CW, Takahashi JS, Konopka G, Greene RW (2020) An essential role for MEF2C in the cortical response to loss of sleep in mice. eLife 9. doi:10.7554/eLife.58331

Chang YH, Katoh MC, Abdellatif AM, Xiafukaiti G, Elzeftawy A, Ojima M, Mizuno S, Kuno A, Takahashi S (2020) Uncovering the role of MAFB in glucagon production and secretion in pancreatic alpha-cells using a new alpha-cell-specific Mafb conditional knockout mouse model. Exp Anim Tokyo 69(2): 178-188. Doi:10.1538/expanim.19-0105

Choi D, Sato T, Ando T, Abe T, Akamatsu M, Kitazaki S (2020) Effects of cognitive and visual loads on driving performance after take-over request (TOR) in automated driving. Appl Ergon 85. Doi:10.1016/j.apergo.2020.103074

Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y (2020) Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. Internal Med 59(4): 577-579. Doi:10.2169/internalmedicine.2947-19

Deng ZB, Matsumoto Y, Kuno A, Ojima M, Xiafukaiti G, Takahashi S (2020) An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition. Int J Mol Sci 21(16). Doi:10.3390/ijms21165606

Disha SI, Furlani B, Drevensek G, Plut A, Yanagisawa M, Hudoklin S, Zitnik IP, Marc J, Drevensek M (2020) The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on-ETB knockout rats. Sci Rep 10(1). Doi:10.1038/s41598-020-71159-8

Enomoto M, Kitamura S, Tachimori H, Takeshima M, Mishima K (2020) Long-term use of hypnotics: Analysis of trends and risk factors. Gen Hosp Psychiat 62: 49-55. Doi:10.1016/j.genhosppsych.2019.11.008

Fujino M, Tagami A, Ojima M, Mizuno S, Abdellatif AM, Kuno A, Takahashi S (2020) c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells. Exp Anim Tokyo 69(2): 242-249. Doi:10.1538/expanim.19-0137

Fukuda K, Shibata Y, Sato H, Okabe S (2020) How the large-scale blackout following the 2018 Hokkaido Eastern Iburi earthquake impacted adolescents’ sleep patterns. Sleep Biol Rhythms 18(4): 351-354. Doi:10.1007/s41105-020-00278-6

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Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1-2):142-9.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I. Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun. 2014 Jul 18. pii: S0889- 1591(14)00400-0.

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563-77.

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and – independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

Doki S, Sasahara S, Matsuzaki I. Psychological approach of occupational health service to sick leave due to mental problems: a systematic review and meta-analysis. Int Arch Occup Environ Health. 2014 Nov 8.

Noriki Kutsumura, Shohei Toguchi, Masatoshi Iijima, Osamu Tanaka, Izumi Iwakura, Takao Saito, DBUpromoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups, Tetrahedron, Volume 70, Issue 43, 28 October 2014, Pages 8004-8009.

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. Biochem Biophys Res Commun. 2014 Dec 12. pii: S0006-291X(14)02174-3.

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi JI. Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species. Exp Anim. 2014 Jul 22.

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9.

Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.

Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Exp Neurol. 2014 Mar;253:82-90.

Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics. Pharmacol Biochem Behav. 2014 Jan;116:129-36.

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H. Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes. PLoS One. 2014 Jun 12;9(6):e99961.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19.

Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H. Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb. 2014 Aug 26;21(8):799-815.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014 Jun 16;4:5312.

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J. Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice. Hepatology. 2014 May;59(5):1791- 802.

Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014 May;155(5):301-

13. Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D. Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell Rep. 2014 May 8;7(3):697-704.

Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16.

Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagasea H. Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4980-3.

Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H. Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4895-8

Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel delta opioid agonist: receptor internalisation, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Jul 22.

Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H. Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2851-4.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 7;82(3):573-86.

Sugiyama A, Nagase H, Oka JI, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1) selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79C:314-320.

Ishikawa K, Tomatsu M, Nagase H, Fujii H. Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α–Aminoketons. HETEROCYCLES. 2014 Jan 1;88(2):1051-1063.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease. J Exp Med. 2014 Dec 22.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award (2013). Life Sci. 2014 Nov 24;118(2):87-90.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24;118(2):77-86.

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. Life Sci. 2014 Nov 24;118(2):70-6.

Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R978-89.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504.

Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action. Cell Metab. 2014 Jun 3;19(6):927-40.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. PLoS One. 2014 May 22;9(5):e97972.

Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014 Jan 20;5:3147.

Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S. Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb. PLoS One. 2014 Nov 14;9(11):e113022.

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol. 2014 Nov 15;276(1- 2):142-9.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2546-57.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In vivo image analysis using iRFP transgenic mice. Exp Anim. 2014;63(3):311-9.

Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim. 2014;63(2):133-40.

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol. 2014 Jun;25(6):1282-90.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Mar 10;211(3):563- 77.

Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I. Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci. 2014 Jan 23;15(2):1700-18.

Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92.

Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins. Methods Mol Biol. 2014;1164:177-96.

Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One. 2014 Sep 12;9(9):e106969.

Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. Psychopharmacology (Berl). 2014 Jul;231(14):2825-37.

Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Apr 15;11(1):9.

Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife. 2014 Mar 25;3:e02172.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacology. 2014 Oct;85:451-60.

Mogk S, Meiwes A, Shtopel S, Schraermeyer U, Lazarus M, Kubata B, Wolburg H, Duszenko M. Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS. PLoS One. 2014 Mar 11;9(3):e91372.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014 Nov 14;289(46):31950-9.

Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014 Oct 8;8:311.

Marowsky A, Vogt KE. Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits. 2014 Mar 25;8:27.

Noriki K, Shohei T, Masatoshi I, Osamu T, Izumi I, Takao S. DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups. Tetrahedron. 2014 Oct 28;70:43:8004-8009.

Saito T, Sonoki Y, Otani T, Kutsumura N. Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives. Org Biomol Chem. 2014 Oct 9;12(42):8398-407.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: The next generation. Life Sci. 2014 Aug 15.

Kashiwagi T, Fuchigami T, Saito T, Nishiyama S, Atobe M. Sequential paired electrosynthesis of a diaryl ether derivative using an electrochemical microreactor. Chem Lett. 2014 Jun 5;43(6):799-801.

Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013; 13 (6): 881-7.

Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K. Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice. G3 (Bethesda). 2013; 3 (9): 1545-52.

Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d’Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat. 2013; 7: 43.

Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y. COX-2-Derived PGE2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the EP3 Receptor. Circ Res. 2013. Jul 5; 113 (2): 104-14.

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata. J. Comp. Neurol. 2013.

Takase K, Oda S, Kuroda M, Funato H. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PLoS One. 2013; 8 (3): e58473.

Suzuki A, Sinton CM, Greene RW, Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 2013; 110 (25): 10288-93.

Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis. Endocrinology. 2013; 154 (10): 3577-88.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013; 4: 2883.

Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka T. Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab. 2013; 305 (11): E1415-25.

Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 2013; 4: 2563.

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T. Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice. PLoS One. 2013; 8 (7): e70012.

Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. PLoS One. 2013; 8 (4): e62391.

Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T. Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. J Neurosci. 2013; 33 (36): 14549-57.

Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M. κ Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Scientific Reports. 2013; 3: 3213.

Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H. The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists. Bioorg Med Chem. 2013; 21 (24): 7628-47.

Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013; 155 (6): 1323-36.