2019.11.12

Comparison of the effects of an orexin inhibitor and a GABA agonist on physical and cognitive functions

Researchers including Dr. Kumpei Tokuyama and Dr. Toshio Kokubo at WPI-IIIS, and graduate students, Jaehoon Seol and Yuya Fujii, at Physical Education, Health, and Sport Sciences, University of Tsukuba, compared the pharmacological effects of an orexin receptor antagonist (suvorexant) and a GABA agonist (brotizolam) on physical and cognitive functions upon forced awakening when the drug effect was maximal. They found that, compared with the GABA receptor agonist, the orexin receptor antagonist induced less impairment in body balance after taking the medicine.

The article, “Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening” was published online in Proc Natl Acad Sci USA on November 11, 2019.

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  • Comparison of the effects of an orexin inhibitor and a GABA agonist on physical and cognitive functions