Kazuo Mishima

Affiliation:Department of Neuropsychiatry, Akita University Graduate School of Medicine

Research Title

Human sleep

Clinical research on sleep-wake disorders

01 Research Summary

Our main research topics are epidemiological surveys, development of diagnosis and treatment algorithms, and pathophysiological research on sleep-wake disorders from a clinical view point. Epidemiological surveys are conducted as part of research projects by the Ministry of Health, Labor and Welfare on sleep habit problems, prevalence of sleep-wake disorders, and actual status of psychotropic drugs prescription in Japanese. We are also working on development of on-line diagnostic system for sleep-wake disorders, development of treatment algorithms with improvement of cognitive / social function as a final endpoint, and development of cognitive behavior therapy for insomnia and circadian rhythm sleep-wake disorders. We are also conducting basic research on pathology of hypersomnia, insomnia and circadian rhythm sleep-wake disorders. Abnormality of biological clocks including extended circadian period, deteriorated photosensitivity, and disease susceptibility genes of circadian rhythm sleep-wake disorders are our recent focus.


Department of Neuropsychiatry, Akita University Graduate School of Medicine

02 Major achievements

Ayabe N, Okajima I, Nakajima S, Inoue Y, Watanabe N, Yamadera W, et al. Effectiveness of cognitive behavioral therapy for pharmacotherapy-resistant chronic insomnia: a multi-center randomized controlled trial in Japan. Sleep Med. 2018;50:105-112.:10.1016/j.sleep.2018.05.038. Epub Jun 18

Hida A, Ohsawa Y, Kitamura S, Nakazaki K, Ayabe N, Motomura Y, et al. Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders. Transl Psychiatry. 2017;7(4):e1106. doi: 10.038/tp.2017.75.

Kitamura S, Katayose Y, Nakazaki K, Motomura Y, Oba K, Katsunuma R, et al. Estimating individual optimal sleep duration and potential sleep debt. Sci Rep. 2016;6:35812.:10.1038/srep35812.

03 Education/Academic background and major awards

Education/Academic background

1994 Akita University Graduate School of Medicine (Ph.D. in Medicine)
1997-2005 Akita University School of Medicine
2002 Research Associate, National Science Foundation Center for Biological Timing, University of Virginia
2002-2003 Visiting Associate Professor, Stanford University
2006-2018 Director, National Center of Neurology and Psychiatry
2018-Present Professor, Akita University Graduate School of Medicine


1989年 The 26th Erwin Von Bälz Preis
2002年 Research Encouragement Award, Japanese Society of Sleep Research
2017年 The 54th Erwin Von Bälz Preis