Kazuo Mishima

Our main research topics are epidemiological surveys, development of diagnosis and treatment algorithms, and pathophysiological research on sleep-wake disorders from a clinical view point. Epidemiological surveys are conducted as part of research projects by the Ministry of Health, Labor and Welfare on sleep habit problems, prevalence of sleep-wake disorders, and actual status of psychotropic drugs prescription in Japanese. We are also working on development of on-line diagnostic system for sleep-wake disorders, development of treatment algorithms with improvement of cognitive / social function as a final endpoint, and development of cognitive behavior therapy for insomnia and circadian rhythm sleep-wake disorders. We are also conducting basic research on pathology of hypersomnia, insomnia and circadian rhythm sleep-wake disorders. Abnormality of biological clocks including extended circadian period, deteriorated photosensitivity, and disease susceptibility genes of circadian rhythm sleep-wake disorders are our recent focus.